A5081393364- Bone and Joint Diseases
- Anesthesia and Pain Management
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Mesenchymal stem cell research
- Bone health and treatments
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Nausea and vomiting management
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bone fractures and treatments
- Lower Extremity Biomechanics and Pathologies
- Periodontal Regeneration and Treatments
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Neuroblastoma Research and Treatments
- Ovarian function and disorders
- Hip and Femur Fractures
- Lung Cancer Research Studies
- Marine and Offshore Engineering Studies
- Neuroendocrine Tumor Research Advances
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Lanzhou University
2017-2024
First Hospital of Lanzhou University
2017-2024
Dalian University of Technology
2024
Inner Mongolia Medical University
2017-2024
PLA Academy of Military Science
2021
Chinese PLA General Hospital
2021
Chengdu University
2018-2020
Nanchang University
2016-2019
Glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) is a serious bone disease that often affects young individuals. Bone grafting combined with core decompression mainly used in clinic to treat GC-ONFH. However, outcome usually not satisfactory, as expected. Here, we report an engineered exosome-functionalized extracellular matrix-mimicking hydrogel for promoting repair Compared Con-Exo, exosomes secreted by marrow stem cells (BMSCs) conventional culture medium, Li-Exo,...
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common debilitating disease that occurs in young and middle-aged adults.
Corticosteroids-induced Dickkopf-1 (DKK1) upregulation and Wnt signaling inhibition result in bone metabolism disorder steroid-associated osteonecrosis (SAON). Implanting biomaterials to regulate the pathway is a promising method repair challenging defects associated with SAON. Here, tetrahedral DNA nanostructures (TDNs) are fabricated as gene carriers deliver MiR335-5p, which targets DKK1 translation. Heparin lithium hydrogel (Li-hep-gel) synthesized act MiR@TDNs delivery agent. Finally,...
Dual delivery of demineralized bone matrix (DBM) powder and hypoxia-pretreated marrow stromal cells (BMSCs) using an injectable self-healing hydrogel enhances regeneration.
Hydroxyapatite (HA) is a commonly used biomaterial in bone-tissue engineering, but pure HA deficient osteoinduction. In this study, we fabricated scaffolds of lithium-doped (Li-HA) and assess the bone generation enhancement Li-HA seeded with hypoxia-preconditioned bone-marrow mesenchymal stem cells (BMMSCs). We found that 1.5%Li-HA obtained optimal cell proliferation activity vitro. an vivo Li-HA/BMSCs enhanced new formation, reducing GSK-3β increasing β-catenin, angiogenic effect was not...
Low doses of corticosteroids have been proved to be effective in decreasing the inflammatory cytokines and relieving pain. However, optimal dosage total knee arthroplasty (TKA) is undetermined. A 103 patients were randomly divided into three groups. Group containing 32 received normal saline. B including 36 used two 100 mg hydrocortisone, given 2 hours before 8 after surgery. C involving 35 four apart. The level interleukin 6 (IL-6) C-reactive protein (CRP) lower group than those when...
Abstract Background Autophagy has been reported to increase in cancer cells after radiation. However, it remains unknown whether increased autophagy as a result of radiation affects DNA damage repair and sensitizes cells. In this study, the radiosensitization effect rapamycin, mammalian target rapamycin inhibitor that induces autophagy, on human lung adenocarcinoma A549 was investigated. Methods were treated with different concentrations rapamycin. Cell viability evaluated by...
Abstract Purpose The aim of this study was to determine mid-and-long term follow-up results patients with early femoral head osteonecrosis who were treated by modified free vascularized fibular grafting combined core decompression and bone grafting. Methods Forty-four at ONFH included in study. Visual analog scale (VAS) pain scores, range hip motion (ROM), Harris score (HHS) recorded assess the clinical outcome; Western Ontario McMaster Osteoarthritis index (WOMAC) scores Short Form 36...
Glucocorticoids-induced osteonecrosis of the femoral head (GIONFH) is a common refractory disease. In present study, we aimed to synthesize nano-hydroxyapatite-copper-lithium (Cu-Li-nHA) composite porous scaffold promote osteogenesis and angiogenesis functions repair GIONFH by regulating Wnt/β-catenin HIF-1α/VEGF pathways. The physicochemical property was characterized their osteogenic angiogenic effects were tested through serial experimentsin vitroandin vivo. Results showed that 0.25%...
The PIWI-like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation, embryogenesis, growth, and development, as well differentiation maturation multiple organisms. relationships between PIWIL1 expression clinicopathological features of colorectal cancer (CRC) patients were analyzed by us. Survival analysis was performed using the Kaplan-Meier method Cox’s proportional hazards model. high rate tissue obviously higher than that corresponding adjacent tissue. closely related to...
Hydroxyapatite (HA) possesses similar mineral components to bone and good physicochemical properties. Even though pure HA scaffold is brittle, it insufficient in promoting vascularization osteoinductivity. This study was conducted assess whether lithium (Li) incorporated into could improve the scaffolds' inherent shortcomings. In experiments, Li-hydroxyapatite mechanical strength, biocompatibility, biodegradability were researched primarily. vivo studies, Li hydroxyapatite scaffolds...
Hydroxyapatite (HA) is a representative bone repairing biomaterial for its similar composition to human bones and teeth. However, pure HA limited in application some unwanted characteristic, such as it brickle weakness degradation. In this study, we modified by doping magnesium (Mg) the material studied property vitro. Besides, also evaluated calvarial defect repair effect using MgHA combined with rhBMP-2 goat model. According our outcomes, composited Mg made scaffold smooth pore regular....
Total hip arthroplasty for adult patients with a history of infection the in childhood could be more technically demanding procedure due to complicated anatomy and possibility reinfection. Here, we conducted mid-term analysis clinical outcomes such after primary cementless total (THA).We reviewed 101 (101 hips; 51 men; mean age, 52.3 years) who underwent THA between 2008 2015, at 24 years (range, 11-43) since resolution infection. Patients were followed up 6.1 2.1-9.6). Clinical quality life...