A5102872354- Bone and Joint Diseases
- Retinal Diseases and Treatments
- Mesenchymal stem cell research
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Bone health and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pluripotent Stem Cells Research
- Orthodontics and Dentofacial Orthopedics
- Corneal surgery and disorders
- Cholinesterase and Neurodegenerative Diseases
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Electrochemical sensors and biosensors
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Berberine and alkaloids research
- Flavonoids in Medical Research
- Lower Extremity Biomechanics and Pathologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Sensor and Energy Harvesting Materials
- dental development and anomalies
- Diabetic Foot Ulcer Assessment and Management
- Elbow and Forearm Trauma Treatment
- CRISPR and Genetic Engineering
Chengdu University of Traditional Chinese Medicine
2025
Sichuan University
2013-2024
Third Affiliated Hospital of Inner Mongolia Medical College
2024
West China Hospital of Sichuan University
2019-2024
Inner Mongolia University
2024
Shandong Provincial Hospital
2020-2023
Shandong First Medical University
2022-2023
Dalian University
2022-2023
Dalian University of Technology
2022-2023
Shaanxi University of Science and Technology
2022
Corticosteroids-induced Dickkopf-1 (DKK1) upregulation and Wnt signaling inhibition result in bone metabolism disorder steroid-associated osteonecrosis (SAON). Implanting biomaterials to regulate the pathway is a promising method repair challenging defects associated with SAON. Here, tetrahedral DNA nanostructures (TDNs) are fabricated as gene carriers deliver MiR335-5p, which targets DKK1 translation. Heparin lithium hydrogel (Li-hep-gel) synthesized act MiR@TDNs delivery agent. Finally,...
A novel near-infrared (NIR) fluorescent probe CHC-CES1 based on a hemi-cyanine skeleton for detecting carboxylesterase 1 (CES1) activity was developed. Herein, could be specifically hydrolysed to CHC-COOH along with significant NIR fluorescence signal enhancement at 670 nm. Systematic evaluation indicated that possessed an outstanding selectivity and sensitivity towards CES1, good chemical stability in complex biosamples. Finally, successfully used the real-time imaging of endogenous CES1...
What is the expression pattern and functionality of caveolin 1 (CAV1) in endometrium patients with adenomyosis?The stromal CAV1 down-regulated that leads to release a variety molecules either enhance metastatic capacity endometrial cells or contribute adenomyosis-associated dysmenorrhea.Adenomyosis characterized by invasion into uterine myometrium. has been linked tumor progression clinical outcome human malignancies; however, its role adenomyosis development dysmenorrhea still poorly...
Intensive monocular perceptual learning can improve visual acuity, contrast sensitivity, and vernier acuity in the amblyopic eye adults with amblyopia. It is however not clear how much training enhance binocular functions. In current study, we aimed to evaluate effects of on a variety Nineteen anisometropic amblyopes (18.5±1.26yrs, mean±s.e.) were trained grating detection task near each individual's cutoff spatial frequency for 6-10days (630 trials/day). Visual stereoacuity, sensitivity...
To evaluate the subfoveal choroidal thickness (SFCT) in eyes with macular edema (ME) secondary to retinal vein occlusion(RVO), and investigate short term response after a single intravitreal ranibizumab (IVR) injection. What is more, compare SFCT change between central RVO (CRVO) branch (BRVO).In retrospective study, we had collected 36-six treatment-naïve patients unilateral ME (including 19 CRVO 17 BRVO). All received IVR injection newly diagnosed. The was measured at onset 2 weeks of...
Abstract WNT5A, a representative ligand of activating several non‐canonical WNT signal pathways, plays significant roles in oncogenesis and tumor inhibition. It has been shown that the non‐receptor tyrosine kinase SRC is required for WNT5A‐induced invasion osteosarcoma cells. However, precise molecular mechanism underlying WNT5A/SRC‐mediated cells remains poorly defined. The study was designed to explore role ERK1/2 WNT5A/SRC‐induced downstream target SRC/ERK1/2 signalings. We found WNT5A...
Background: Patients with cancer show greater susceptibility and vulnerability to severe acute respiratory syndrome coronavirus 2 infection. However, data on the vaccination status among patients breast any structured analysis of factors influencing patients’ decisions regarding vaccines are lacking. Methods: This cross-sectional study in China was conducted from 1 June 2022, 17 2022. Every participant completed an online questionnaire about their adverse reactions, a scale based Health...
Abstract Glucocorticoid (GC)‐induced osteonecrosis of the femoral head (GC‐ONFH) is considered as one most serious side effects long‐term or over‐dose steroid therapy. However, underlying cause mechanisms are still not fully investigated. We firstly established a rat model GC‐ONFH and injected lipopolysaccharide (LPS) methylprednisolone (MPS). found that expressions Cx43, Runx2, ALP COLⅠ were more decreased than normal group. Secondly, isolated bone marrow stem cells (BMSCs) treated with...
As an atypical member of the Rab family, Rab24 has several attributes distinguishing this protein from other members. Based on yeast two-hybrid system, interaction between human RAB24 and two proteins, cyclophilin A (CyP-A) gamma-aminobutyric acid type receptor-associated (GABARAP), was detected identified in COS-7 cells. Interestingly, is predominantly localized nuclei cells, which different previous reports using cell lines. (D123I) can trigger accumulation intracellular inclusions, with...
Abstract Competency is closely related to the occurrence of behavior. Breastfeeding competence mastery different breastfeeding factors which intervene in could improve However, few studies have paid attention status and influencing competency. The competency pregnant women third trimester pregnancy has greatest impact on behavior after childbirth. Therefore, objective this study were investigate level independent risk for among pregnancy. A cross-sectional survey method convenience sampling...
Ski, an evolutionary conserved protein, is involved in the development of a number tumors, such as Barrett's esophagus, leukemia, colorectal cancer, gastric pancreatic hemangiomas and melanoma. However, studies on functions Ski osteosarcoma (OS) are limited. In this study, firstly differential expression OS tissues osteochondroma was detected, both human cell lines (MG63 U2OS) normal osteoblasts (hFoB1.19) then detected. The results demonstrated that significantly upregulated lines. led us...
ABSTRACT The aerial parts of genus Peganum are officially used in traditional Chinese medicine. paper aims to establish a high‐performance liquid chromatography (HPLC) method for fingerprint analysis and simultaneous determination three alkaloids two flavonoids , analyze accumulative difference secondary metabolites inter‐species, individuals plants, inter‐/intra‐population from different growing seasons. HPLC was performed on C 18 column with gradient elution using 0.1% trifloroacetic acid...