A5101503255- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Enhanced Recovery After Surgery
- Nausea and vomiting management
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Phytochemistry and Bioactive Compounds
- Metabolism and Genetic Disorders
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Chemokine receptors and signaling
- Bioactive Compounds and Antitumor Agents
- Traditional Chinese Medicine Studies
- Trace Elements in Health
- Airway Management and Intubation Techniques
- Tryptophan and brain disorders
- Medicinal Plants and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
Second Hospital of Shandong University
2016-2023
Southern Medical University
2019-2020
State Administration of Traditional Chinese Medicine of the People's Republic of China
2020
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive for hepatocellular carcinogenesis. core components constitute kinase cascade, which inhibits functional activation YAP/TAZ. Interestingly, overactivation YAP/TAZ commonly observed in carcinoma, although inhibitory cascade still functional. Recent studies have indicated that ubiquitin‒proteasome system also plays important roles modulating...
Cervical cancer is the fourth leading type and second most common gynecological malignancy among women worldwide. Silibinin (SB), a chief bioactive natural polyphenolic flavonoid of Silybum marianum L., has been used clinically for its hepatocyte protective effects. It also anticancer effects via induction apoptosis cell cycle arrest. However, SB on cervical cells through mitochondrial fission have not studied. Here, we showed that markedly suppressed proliferation by inducing G2/M arrest...
Acute lung injury (ALI) is a life-threatening disease without effective pharmacotherapies, so far. Forsythia suspensa frequently used in the treatment of infection traditional Chinese medicine. In search for natural anti-inflammatory components, activity and underlying mechanism Forsythoside A (FA) from were explored. present paper, BALB/c mice murine RAW 264.7 cells stimulated by LPS to establish inflammation models. Data showed that FA inhibited production TNF-α IL-6 activation STAT3...
Background: Acute lung injury (ALI) is a life-threatening disease without effective chemotherapy at present. Liang-Ge-San (LGS) famous traditional Chinese medicine formula, which used to treat ALI in China. However, only few studies have addressed the mechanisms of LGS ALI. Purpose: To evaluate anti-inflammatory effects on lipopolysaccharide (LPS)-induced ALI, and explore its underlying molecular mechanism. Methods: Murine RAW264.7 cells were treated with LPS (1 μg/ml). The generation IL-6,...
To investigate, in patients with gastric carcinoma undergoing laparoscopic radical gastrectomy, the effects of ultrasound-guided quadratus lumborum block (UG-QLB) combined general anaesthesia (GA) on postoperative recovery compared GA alone. The retrospective study enrolled 231 including 119 who received UG-QLB (Group QG), and 112 alone GA). primary endpoint was 3-year recurrence-free survival (RFS). secondary endpoints were average visual analogue scale (VAS) scores within 48 h after...
To investigate the effects of ultrasound-guided thoracic paravertebral block combined with general anaesthesia or alone for thoracoscopic lung adenocarcinoma surgery, and to provide new thoughts improving clinical outcomes.This was a retrospective study. Data were retrieved 195 patients undergoing elective radical lobectomy via video-assisted thoracoscopy between January 2018 August 2019 in The Second Hospital Shandong University, including 86 who received (TPVB) (group TG), 109 GA). All...
To evaluate the effect of ultrasound-guided quadratus lumborum block (QLB) preemptive analgesia on recovery in colon cancer patients undergoing open radical surgery and provide reference for its clinical application.From July 2019 to June 2020, according anesthesia method, 56 who received were divided into two groups: Group Q (n=27), which QLB combined general anesthesia, C (n=29), only. Both groups given self-controlled intravenous pump after surgery. The primary outcome is a series...
Purpose: The aim was to investigate the time for intubation, adverse events and comfort score of ultrasound-guided internal branch superior laryngeal nerve block in patients with severe chronic obstructive pulmonary disorder (COPD) undergoing awake fibreoptic nasotracheal intubation. Methods: Sixty COPD who needed intubation were randomly evenly divided into group (group S) control C). All received procedural sedation dexmedetomidine adequate topical anaesthesia upper respiratory tract....