A5101895089- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Kidney Stones and Urolithiasis Treatments
- Infective Endocarditis Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Aortic Disease and Treatment Approaches
- Urological Disorders and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Ferroptosis and cancer prognosis
- Urologic and reproductive health conditions
- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- Blood properties and coagulation
- Congenital Heart Disease Studies
- Genital Health and Disease
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Dialysis and Renal Disease Management
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2022-2025
University Hospital of Bern
2020-2025
University of Bern
2018-2025
ZheJiang Academy of Agricultural Sciences
2023
Northeastern University
2022
Amsterdam University Medical Centers
2020
University of Amsterdam
2020
Sanquin
2020
Chinese PLA General Hospital
2004-2020
Rationale: The role of histone methylation modifications in renal disease, particularly sepsis-induced acute kidney injury (AKI), remains unclear. This study aims to investigate the potential involvement methyltransferase zeste homolog 2 (EZH2) AKI and its impact on apoptosis inflammation. Methods: We first examined expression EZH2 (LPS injection) mice LPS-stimulated tubular epithelial cells. next constructed knockout further confirm effects inflammatory response AKI. And level cells can be...
Abstract Epigenetic regulation is reported to play a significant role in the pathogenesis of various kidney diseases, including renal cell carcinoma, acute injury, fibrosis, diabetic nephropathy, and lupus nephritis. However, epigenetic calcium oxalate (CaOx) crystal deposition-induced injury remains unclear. Our study demonstrated that upregulation enhancer zeste homolog 2 (EZH2)-mediated ferroptosis facilitates CaOx-induced injury. CaOx deposition promoted vivo vitro. Usage liproxstatin-1...
Abstract While stem cells can sense and respond to physical properties of their environment, the molecular aspects how information is translated into biochemical signals remain unknown. Here we show that human mesenchymal (hMSCs) harvest assemble plasma fibronectin extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled ECM fibers are more stretched rigid than soft fibronectin-coated polyacrylamide gels. Culturing single upregulates hMSC osteogenesis....
Calcium oxalate (CaOx) stones are among the most common types of kidney and associated with renal tubular damage, interstitial fibrosis, chronic disease. The mechanism CaOx crystal-induced fibrosis remains unknown. Ferroptosis, a type regulated cell death, is characterised by iron-dependent lipid peroxidation, tumour suppressor p53 key regulator ferroptosis. In present study, our results demonstrated that ferroptosis was significantly activated in patients nephrolithiasis hyperoxaluric mice...
Nephrolithiasis, a common urinary system disorder, exhibits high morbidity and recurrence rates, correlating with renal dysfunction the increased risk of chronic kidney disease. Nonetheless, precise role disrupted cellular metabolism in injury induced by calcium oxalate (CaOx) crystal deposition is unclear. The purpose this study to investigate involvement ubiquitin-like protein containing PHD RING finger structural domain 1 (UHRF1) CaOx-induced fibrosis its impacts on lipid metabolism....
Abstract The incidence of kidney stones is increasing worldwide. However, the underlying mechanism process stone formation and damage caused are not well understood. Here, it observed that Lgals3, a β‐galactoside‐binding protein, significantly increased in tissues with calcium oxalate (CaOx) stones, both vivo vitro models. Lgals3 expression positively correlated deposition CaOx crystals. Knockout markedly reduces crystal renal fibrosis vivo. Furthermore, deficiency decrease glycolytic rate...
Calcium oxalate (CaOx) crystals are known to cause renal injury and trigger inflammatory responses. However, the role of exosome-mediated epithelial-macrophage communication in CaOx-induced kidney remains unclear. To identify key molecules, miRNA sequencing was conducted on exosomes derived from CaOx-treated (CaOx-exo) control (Ctrl-exo) epithelial cells, identifying miR-93-3p as significantly upregulated. A combination dual-luciferase reporter assays, Western blot, RT-qPCR,...
The potential association between calcium oxalate stones and renal fibrosis has been extensively investigated; however, the underlying mechanisms remain unclear. Ferroptosis is a novel form of cell death characterized by iron-dependent lipid peroxidation regulated acyl coenzyme A synthase long-chain family member 4 (ACSL4). Yes-associated protein (YAP), transcriptional co-activator in Hippo pathway, promotes ferroptosis modulating ACSL4 expression. Nevertheless, involvement YAP-ACSL4...
<h3>Objective</h3> To investigate prediction of cerebral venous thrombosis (CVT) by clinical variables and D-dimer levels. <h3>Methods</h3> This prospective multicenter study included consecutive patients with clinically possible CVT. On admission, underwent examination, blood sampling for D-dimers measuring (ELISA test), magnetic resonance/CT venography. Predictive value CVT was calculated. A score to stratify into groups low, moderate, or high risk established multivariate logistic...
An increasing number of inflammatory responses and alternative splicing (AS) have been recently reported to be associated with various kidney diseases. The effect response on acute injury (AKI) has not fully clarified. In the present study, a mouse model AKI induced by cisplatin ischemia‑reperfusion (IR) was established genome‑wide profiling analysis identification differentially expressed genes (DEGs) in tissue conducted Gene Ontology (GO) functional analysis, Kyoto Encyclopedia Genes...
The rooftop farm is of increasing interest in urban food production and greening, which operates with less environmental impact than conventional farms. However, the evidence about bacterial community composition soil environment still insufficient. In this study, three sampling sites (the original sample, samples after a seven-year natural cycle, microcirculation system) were selected to study properties, communities, relationship between two farm. Based on high-throughput sequencing, 61...
The PIWI-like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation, embryogenesis, growth, and development, as well differentiation maturation multiple organisms. relationships between PIWIL1 expression clinicopathological features of colorectal cancer (CRC) patients were analyzed by us. Survival analysis was performed using the Kaplan-Meier method Cox’s proportional hazards model. high rate tissue obviously higher than that corresponding adjacent tissue. closely related to...
An increasing body of evidence suggests important roles extracellular matrix (ECM) in regulating stem cell fate. This knowledge can be exploited tissue engineering applications for the design ECM scaffolds appropriate to direct differentiation. By probing conformation fibronectin (Fn) using fluorescence resonance energy transfer (FRET), we show here that heparin treatment fibroblast-derived resulted more extended conformations fibrillar Fn ECM. Since is a highly negatively charged molecule...
Abstract To investigate the surgical outcomes of vesiculoscopy on refractory hematospermia and ejaculatory duct obstruction (EDO), clinical data (including pelvic magnetic resonance imaging (MRI) examinations long-term effects endoscopic treatment) from 305 patients were analyzed. Four main etiologic groups found MRI. We that 62.0% (189/305) showed abnormal signal intensity in MRI investigations seminal vesicle (SV) area. Cystic lesions observed 36.7% (112/305) patients. The third sign was...