A5101465107- Proteins in Food Systems
- Cell death mechanisms and regulation
- Microencapsulation and Drying Processes
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Collagen: Extraction and Characterization
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Kidney Stones and Urolithiasis Treatments
- Curcumin's Biomedical Applications
- Food Chemistry and Fat Analysis
- Protein Degradation and Inhibitors
- Pickering emulsions and particle stabilization
- RNA Interference and Gene Delivery
- Meat and Animal Product Quality
- Synthesis of Tetrazole Derivatives
- Biochemical Analysis and Sensing Techniques
- Testicular diseases and treatments
- Cancer therapeutics and mechanisms
- Ubiquitin and proteasome pathways
- Protein Hydrolysis and Bioactive Peptides
- Histone Deacetylase Inhibitors Research
Shanghai Jiao Tong University
2020-2025
Shanghai Ocean University
2023-2025
Renmin Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
Kunming Medical University
2025
Beijing Shijitan Hospital
2024
Capital Medical University
2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Beijing Municipal Education Commission
2024
Herein, six types of polyphenol-crosslinked gelatin conjugates (PGCs) with ≥ two molecules were prepared using a covalent crosslinking method polyphenols (tannic acid and caffeic acid) three gelatins (bovine bone gelatin, cold water fish skin porcine gelatin) for the emulsion stabilization. The structural functional properties PGCs dependent on both polyphenol types. storage stability conjugate-stabilized emulsions was crosslinking, NaCl addition, heating pretreatment. In particular,...
A focused library of analogues the dual PLK1 kinase/BRD4 bromodomain inhibitor BI-2536 was prepared and then analyzed for BRD4 inhibitory activities. Particularly, replacement cyclopentyl group with a 3-bromobenzyl moiety afforded most potent series (39j) K i = 8.7 nM, which equipotent against PLK1. The superior affinity 39j over parental compound to possibly derives from improved interactions WPF shelf. Meanwhile, substitution pyrimidine NH an oxygen atom reversed PLK1/BRD4 selectivity...
The rational design of inhibitors the bHLH-ZIP oncoprotein c-Myc is hampered by a lack structure in its monomeric state. We describe herein novel, low-molecular-weight, synthetic α-helix mimetics that recognize helical transcriptionally active coiled-coil association with obligate partner Max. These compounds perturb heterodimer's binding to canonical E-box DNA sequence without causing protein–protein dissociation, heralding new mechanistic class "direct" inhibitors. In addition...
Calcium oxalate (CaOx) stones are among the most common types of kidney and associated with renal tubular damage, interstitial fibrosis, chronic disease. The mechanism CaOx crystal-induced fibrosis remains unknown. Ferroptosis, a type regulated cell death, is characterised by iron-dependent lipid peroxidation, tumour suppressor p53 key regulator ferroptosis. In present study, our results demonstrated that ferroptosis was significantly activated in patients nephrolithiasis hyperoxaluric mice...
Abstract The incidence of kidney stones is increasing worldwide. However, the underlying mechanism process stone formation and damage caused are not well understood. Here, it observed that Lgals3, a β‐galactoside‐binding protein, significantly increased in tissues with calcium oxalate (CaOx) stones, both vivo vitro models. Lgals3 expression positively correlated deposition CaOx crystals. Knockout markedly reduces crystal renal fibrosis vivo. Furthermore, deficiency decrease glycolytic rate...
Background: Acute kidney injury (AKI) is a syndrome characterized by precipitous decline in function, posing significant threat to patient survival. The role of RNA binding protein (RBP) AKI remains insufficiently understood and we found an important RBP, Lgals3, that may mediate the progress AKI. Methods: Lgals3 -/- mice, Nr4a1 mice cross-linking immunoprecipitation high-throughput sequencing were performed examine targeted proteins. Results: expression was notably elevated vivo vitro...
The potential association between calcium oxalate stones and renal fibrosis has been extensively investigated; however, the underlying mechanisms remain unclear. Ferroptosis is a novel form of cell death characterized by iron-dependent lipid peroxidation regulated acyl coenzyme A synthase long-chain family member 4 (ACSL4). Yes-associated protein (YAP), transcriptional co-activator in Hippo pathway, promotes ferroptosis modulating ACSL4 expression. Nevertheless, involvement YAP-ACSL4...
We herein report on the pharmacophore determination of ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to discovery compounds with greater selectivities for inhibiting proliferation melanoma cells containing active signaling.
Transcription factors are DNA-binding proteins that – usually in combination with other to form the pre-initiation complex (PIC) regulate transcription of specific DNA sequences (genes) into mRNA by controlling recruitment RNA polymerase II. Constitutive activation can lead a variety cancers, and are, therefore, important therapeutic targets. However, stark contrast targeting enzyme active sites, disruption protein–protein or protein–DNA interactions involved transcriptional machinery is...
Abstract The disruption of aberrant protein–protein interactions (PPIs) with synthetic agents remains a challenging goal in contemporary medicinal chemistry but some progress has been made. One such dysregulated PPI is that between the anti‐apoptotic Bcl‐2 proteins, including myeloid cell leukemia‐1 (Mcl‐1), and α‐helical homology‐3 (BH3) domains its pro‐apoptotic counterparts, as Bak. Herein, we describe discovery small‐molecule inhibitors Mcl‐1 oncoprotein based on novel chemotype....
The effects of transmembrane (TMEM) proteins in the progression prostate cancer (PCa) remain unknown. This study aims to explore functions TMEM100 PCa. To expression, regulation, and PCa, two PCa cell lines 30 tissue samples with adjacent control tissues were examined. Online databases, immunohistochemistry, immunofluorescence, western blot, flow cytometry, colony formation, wound healing, transwell assays, xenograft mouse models used relevant expression was shown decrease patients, low...
In this study, we developed an efficient method for the synthesis of aryl amides from sodium thiosulfate pentahydrate, organic anhydrides, and azides. Sodium may be used as sulfur source, which reacts with anhydrides to generate acyl-Bunte salt; salt azides via in situ generation thiocarboxylate. Using our method, successfully synthesized a key bioactive compound. The advantages one-pot two-step reactions include operational simplicity, structurally diverse products favorable yields, use...