A5064624917- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Natural Products and Biosynthesis
- Neonatal Health and Biochemistry
- Cannabis and Cannabinoid Research
- Enzyme Catalysis and Immobilization
- Antibiotic Resistance in Bacteria
- Cytokine Signaling Pathways and Interactions
- Bacterial Genetics and Biotechnology
- Viral Infectious Diseases and Gene Expression in Insects
- Synthesis of heterocyclic compounds
- Protein purification and stability
- Melanoma and MAPK Pathways
- Infectious Encephalopathies and Encephalitis
- Catalytic C–H Functionalization Methods
- Computational Drug Discovery Methods
Center for Drug Evaluation and Research
2018-2019
University of Maryland, Baltimore
2013-2018
New therapeutic targets are required to combat multidrug resistant infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due links between iron and virulence dependence on an source during infection. Herein we report synthesis activity a series iminoguanidine-based inhibitors HemO. Compound 23 showed binding affinity 5.7 μM MIC50 52.3 μg/mL against P. aeruginosa PAO1. An in cellulo assay was developed by coupling HemO biliverdin-IXα-dependent infrared...
We herein report on the pharmacophore determination of ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to discovery compounds with greater selectivities for inhibiting proliferation melanoma cells containing active signaling.
Bacteria require iron for survival and virulence employ several mechanisms including utilization of the host heme containing proteins. The final step in releasing is oxidative cleavage by HemO. A recent computer aided drug design (CADD) study identified inhibitors bacterial HemOs. Herein we report near complete HN, N, CO, Cα, Cβ chemical shift assignment P. aeruginosa HemO absence presence (E)-3-(4-(phenylamino)phenylcarbamoyl)acrylic acid (3) (E)-N′-(4-(dimethylamino)benzylidene)...
Abstract Base‐mediated cyclocondensation of chalcones and triazol‐3‐amines produces triazolopyrimidines.