A5068279887- Adaptive Control of Nonlinear Systems
- Kidney Stones and Urolithiasis Treatments
- Distributed Control Multi-Agent Systems
- Stability and Control of Uncertain Systems
- Chronic Kidney Disease and Diabetes
- Ferroptosis and cancer prognosis
- Fluid Dynamics and Vibration Analysis
- Smart Grid Security and Resilience
- Network Security and Intrusion Detection
- Vibration and Dynamic Analysis
- Fault Detection and Control Systems
- Renal cell carcinoma treatment
- Traffic control and management
- Extracellular vesicles in disease
- Vehicle emissions and performance
- Epigenetics and DNA Methylation
- Neural Networks Stability and Synchronization
- Immune cells in cancer
- Wind and Air Flow Studies
- Renal and related cancers
- Zebrafish Biomedical Research Applications
- Adaptive Dynamic Programming Control
- Genetic and Kidney Cyst Diseases
- Gut microbiota and health
- Fluid Dynamics and Turbulent Flows
Wuhan University
2021-2025
Renmin Hospital of Wuhan University
2021-2025
Zhejiang University of Technology
2019-2025
Southern Medical University
2021-2023
University Town of Shenzhen
2023
Tsinghua University
2023
Tsinghua–Berkeley Shenzhen Institute
2023
Sinopec (China)
2020-2022
China University of Petroleum, Beijing
2017-2018
This paper is concerned with the intelligent event-triggering-based positioning control of networked unmanned marine vehicle (UMV) systems hybrid attacks, where UMV and station connected by a communication network DoS attack Deception are studied. Firstly, stochastic switched Takagi-Sugeno (T-S) fuzzy system model proposed for nonlinear subject to aperiodic random attack. Then, novel asynchronous advantage actor-critic (A3C) learning-based event-triggering approach introduced alleviate load....
This paper is concerned with security control of nonlinear unmanned marine vehicle (UMV) systems under a networked environment. The UMV system and land-based station are connected by communication network. Considering the limited resource in environment, dynamic event-triggering mechanisms proposed sensor to controller actuator sides simultaneously. Meanwhile, triggered output data then quantized logarithmic quantizer before being sent remote station. First, based on Takagi-Sugeno (T-S)...
Rationale: The role of histone methylation modifications in renal disease, particularly sepsis-induced acute kidney injury (AKI), remains unclear. This study aims to investigate the potential involvement methyltransferase zeste homolog 2 (EZH2) AKI and its impact on apoptosis inflammation. Methods: We first examined expression EZH2 (LPS injection) mice LPS-stimulated tubular epithelial cells. next constructed knockout further confirm effects inflammatory response AKI. And level cells can be...
Abstract Epigenetic regulation is reported to play a significant role in the pathogenesis of various kidney diseases, including renal cell carcinoma, acute injury, fibrosis, diabetic nephropathy, and lupus nephritis. However, epigenetic calcium oxalate (CaOx) crystal deposition-induced injury remains unclear. Our study demonstrated that upregulation enhancer zeste homolog 2 (EZH2)-mediated ferroptosis facilitates CaOx-induced injury. CaOx deposition promoted vivo vitro. Usage liproxstatin-1...
This article addresses the dynamic positioning control problem of a nonlinear unmanned marine vehicle (UMV) system subject to network communication constraints and deny-of-service (DoS) attack, where dynamics UMV are described by Takagi-Sugeno (T-S) fuzzy (TSFS). In order save limited resource, new intelligent event-triggering mechanism is proposed, in which event triggering threshold optimized Q -learning algorithm. Then, switched approach proposed deal with aperiodic DoS attack occurring...
Flow-induced vibration (FIV) of a circular cylinder with an attached splitter plate in laminar flow Re = 100 is studied numerically. First, the mechanical model along mathematical formulations proposed to describe fluid-structure interaction (FSI) between elastically supported cylinder–plate body and surrounding flow. Subsequently, FSI solution procedure developed based on characteristic-based split finite element method, its accuracy stability are validated using vortex-induced vibrations...
This article is concerned with the co-design of fault detection and consensus control protocol for a class multi-agent systems (MASs) subject to Denial-of-Service attack, where attack behavior hidden defender as adversary may launch different durations but not know real situation at each time instant. Due complicated behavior, semi-Markov process introduced only observed modes emitted by inaccessible ones are available. The probability density functions sojourn kernel adopted help analyze...
The present study aimed to evaluate the role and mechanism of ferrostatin‑1 (Fer‑1) in oxalate (Ox)‑induced renal tubular epithelial cell injury, fibrosis, calcium (CaOx) stone formation. A CaOx model mice kidneys was established via intraperitoneal injection 80 mg/kg glyoxylic acid for 14 days. were randomly divided into three groups (n=6), namely, control (Con), group, + Fer‑1 group. Cultured human cells (HK‑2 cells) (n=3), Ox levels heme oxygenase 1 (HO‑1), superoxide dismutase 2 (SOD2),...
Calcium oxalate (CaOx) stones are among the most common types of kidney and associated with renal tubular damage, interstitial fibrosis, chronic disease. The mechanism CaOx crystal-induced fibrosis remains unknown. Ferroptosis, a type regulated cell death, is characterised by iron-dependent lipid peroxidation, tumour suppressor p53 key regulator ferroptosis. In present study, our results demonstrated that ferroptosis was significantly activated in patients nephrolithiasis hyperoxaluric mice...
Abstract This brief is aimed to deal with the intelligent control problem of near‐space vehicle (NSV) systems, where sliding mode (SMC) frame based on a finite‐time extended state observer (FTESO) adopted. First, Takagi‐Sugeno (T‐S) fuzzy model used capture nonlinear dynamics NSV systems. Second, FTESO devised estimate and external perturbation. Third, robust SMC algorithm estimated disturbance designed realize attitude angle tracking target system. In simulation part, re‐entry task utilized...
Nephrolithiasis, a common urinary system disorder, exhibits high morbidity and recurrence rates, correlating with renal dysfunction the increased risk of chronic kidney disease. Nonetheless, precise role disrupted cellular metabolism in injury induced by calcium oxalate (CaOx) crystal deposition is unclear. The purpose this study to investigate involvement ubiquitin-like protein containing PHD RING finger structural domain 1 (UHRF1) CaOx-induced fibrosis its impacts on lipid metabolism....
Abstract The incidence of kidney stones is increasing worldwide. However, the underlying mechanism process stone formation and damage caused are not well understood. Here, it observed that Lgals3, a β‐galactoside‐binding protein, significantly increased in tissues with calcium oxalate (CaOx) stones, both vivo vitro models. Lgals3 expression positively correlated deposition CaOx crystals. Knockout markedly reduces crystal renal fibrosis vivo. Furthermore, deficiency decrease glycolytic rate...
Background: Acute kidney injury (AKI) is a syndrome characterized by precipitous decline in function, posing significant threat to patient survival. The role of RNA binding protein (RBP) AKI remains insufficiently understood and we found an important RBP, Lgals3, that may mediate the progress AKI. Methods: Lgals3 -/- mice, Nr4a1 mice cross-linking immunoprecipitation high-throughput sequencing were performed examine targeted proteins. Results: expression was notably elevated vivo vitro...
The potential association between calcium oxalate stones and renal fibrosis has been extensively investigated; however, the underlying mechanisms remain unclear. Ferroptosis is a novel form of cell death characterized by iron-dependent lipid peroxidation regulated acyl coenzyme A synthase long-chain family member 4 (ACSL4). Yes-associated protein (YAP), transcriptional co-activator in Hippo pathway, promotes ferroptosis modulating ACSL4 expression. Nevertheless, involvement YAP-ACSL4...
The finite-time dynamic positioning controller design problem of the unmanned marine vehicle (UMV) system under switching DoS attacks is investigated. Firstly, an adaptive memory-based event-triggering communication mechanism (METCM) designed to save networked resources in maritime environment. Second, signals released by are quantized further reduce bandwidth network. In addition, since adversary may have multiple attack strategies, thus a hierarchical semi-Markov process (HS-MP) presented...