A5072480535- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Hemophilia Treatment and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Kruppel-like factors research
- CAR-T cell therapy research
- Blood disorders and treatments
- Sex and Gender in Healthcare
University Hospital of Bern
2021-2025
University of Bern
2021-2025
Ottawa Hospital
2024
(1) Background: Polycythaemia is defined by an increase in haemoglobin (Hb) concentration, haematocrit (Hct) or red blood cell (RBC) count above the reference range adjusted to age, sex and living altitude. JAK2 unmutated polycythaemia frequent but under-investigated original publications. In this retrospective cohort study, we investigated clinical laboratory data, underlying causes, management outcomes of patients. (2) Methods: The hospital database was searched identify patients...
(1) Background: Thrombophilia testing utility has remained controversial since its clinical introduction, because data on influence treatment decisions are limited. (2) Methods: We conducted a single-center retrospective cohort study of 3550 unselected patients referred for thrombophilia consultation at the Bern University Hospital in Switzerland from January 2010 to October 2020. studied results and evaluated association between thromboembolic pregnancy-related morbidity events after up...
(1) Background: Clinical and molecular data on patients with unexplained erythrocyto-sis is sparse. We aimed to analyze the clinical features of congenital erythrocytosis in our tertiary reference center. (2) Methods: In 34 erythrocytosis, a 13-gene Next-Generation Sequencing panel developed at center was conducted. (3) Results: 6/34 (18%) patients, eight different heterozygous gene variants were found. These were, therefore, diagnosed erythrocytosis. Two had two each. All characterized as...
The collected evidence on thrombophilia guidelines is scarce and data about their impact clinical decisions are unknown. We aimed to investigate the adherence testing guidelines, its therapeutic in patients with guideline-adherent non-adherent identify patients' characteristics mostly associated treatment decisions.We conducted a single-center cross-sectional study of referred for at outpatient clinic tertiary hospital between 01/2010-10/2020. systematically evaluated internal influence test...
It is currently unknown whether thrombin generation associated with venous thromboembolism (VTE) recurrence, major bleeding, and mortality in the elderly. Therefore, our aim was to prospectively study association between VTE bleeding elderly patients acute VTE. Consecutive aged ≥65years were followed for 2 years starting from 1 year after index Primary outcomes mortality. Thrombin assessed 565 At this time, 59% of still anticoagulated. discriminatory but not non-anticoagulated...
It is currently unknown whether thrombin generation associated with venous thromboembolism (VTE) recurrence, major bleeding, or mortality in the elderly. Therefore, our aim was to prospectively study association between and VTE elderly patients acute VTE. Consecutive aged ≥65 years were followed for 2 years, starting from 1 year after index Primary outcomes mortality. Thrombin assessed 551 At this time, 59% of still anticoagulated. discriminatory but not bleeding non-anticoagulated patients....
Introduction: Guidelines on thrombophilia are based expert recommendations since the collected evidence is scarce. Furthermore, about their yield clinical decisions unknown. We aimed to investigate adherence testing guidelines and its therapeutic impact in patients with guideline-adherent non-adherent testing.Materials Methods: conducted a single-center cross-sectional study of referred for at outpatient clinic tertiary hospital between 01/2010-10/2020. systematically evaluated internal...