A5085380635- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Trauma and Emergency Care Studies
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Blood transfusion and management
- Hemophilia Treatment and Research
- Vitamin K Research Studies
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Heparin-Induced Thrombocytopenia and Thrombosis
- Trauma Management and Diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Iron Metabolism and Disorders
University of Bern
2007-2025
Luzerner Kantonsspital
2001-2025
University of Lucerne
2024-2025
University Hospital of Bern
2004-2023
Sanquin
2014-2023
University of Amsterdam
2014-2023
Amsterdam UMC Location University of Amsterdam
2012-2023
Amsterdam University Medical Centers
2018-2022
Cancer Center Amsterdam
2019
Loyola University Medical Center
2019
Multiple organ dysfunction syndrome is a frequent complication of severe sepsis and septic shock has high mortality. We hypothesized that extensive apoptosis cells might constitute the cellular basis for this complication.Retrospective study.Medical surgical wards or intensive care units two university hospitals.Fourteen patients with fever, 15 systemic inflammatory response syndrome, 32 sepsis, eight shock.None.We assessed circulating levels nucleosomes, specific markers released by during...
Objective— The formation of neutrophil extracellular traps and the exposure nucleosomes on these contribute to coagulation activation propagation deep vein thrombosis (DVT) in animal models. However, no data are available role or patients with thrombosis. Methods Results— We conducted a case–control study, which levels circulating elastase–α1-antitrypsin complexes were assessed plasma from 150 objectified symptomatic DVT (cases) compared 195 clinical suspicion but whom was excluded...
Donor fecal microbiota transplantation restores gut microbial diversity and reduces graft-versus-host disease in hematopoietic cell transplant recipients.
Abstract Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, clinical scientists to discuss origin potential consequences of thrombo-inflammation etiology, diagnostics, management patients with disease, including myocardial infarction, stroke, peripheral artery disease. This article presents state-of-the-art...
We evaluated the score for disseminated intravascular coagulation (DIC) recently published by International Society Thrombosis and Haemostasis (ISTH) in a well-defined series of sepsis patients. Thirty-two patients suffering from severe eight with septic shock were following ISTH DIC score. Fibrin monomer D-dimer chosen as fibrin-related markers (FRM), respectively. scores nonsurvivors (n = 13) well higher (P < 0.04) compared survivors sepsis, Using fibrin D-dimer, 30 25% suffered overt DIC....
Experimental work posits that acute ischaemic events trigger haematopoietic activity, driving monocytosis, and atherogenesis. Considering the chronic low-grade inflammatory state in atherosclerosis, we hypothesized hyperactivity is a persistent feature cardiovascular disease (CVD). Therefore, aimed to assess activity of organs stem progenitor cells (HSPCs) humans. First, performed 18F-fluorodeoxyglucose positron emission tomographic (18F-FDG PET) imaging 26 patients with stable...
Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, can form neutrophil extracellular traps. Neutrophil traps consist a meshwork DNA, nucleosomes, histones and proteases. have been demonstrated to be toxic endothelial parenchymal cells. This prospective cohort study was conducted determine trap formation patients during steady state As measure traps, plasma nucleosomes levels were determined...
Human C1-inhibitor (C1-Inh) is a serine protease inhibitor and the major regulator of contact activation pathway as well classical lectin complement pathways. It known to be highly glycosylated plasma glycoprotein. However, both structural features biological role C1-Inh glycosylation are largely unknown. Here, we performed for first time an in-depth site-specific N- O-glycosylation analysis combining various mass spectrometric approaches, including C18-porous graphitized carbon...
Key Points During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter nonhematopoietic cells.
The complement system is an important component of innate immunity. alternative pathway (AP) amplification loop considered essential feed forward mechanism for activation. However, the role AP in classical (CP) activation has only been studied ELISA settings. Here, we investigated its contribution on physiologically relevant surfaces human cells and bacterial pathogens antibody-mediated activation, including autoimmune haemolytic anaemia (AIHA) setting with autoantibodies against red blood...