A5026912085- Platelet Disorders and Treatments
- Blood properties and coagulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Advanced Glycation End Products research
- Protease and Inhibitor Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Cystic Fibrosis Research Advances
- Prostate Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
- Proteins in Food Systems
- Renal Diseases and Glomerulopathies
- Erythrocyte Function and Pathophysiology
- Chronic Kidney Disease and Diabetes
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Microencapsulation and Drying Processes
- Genetic factors in colorectal cancer
- Probiotics and Fermented Foods
- Nutrition, Genetics, and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Humanitas University
2022-2025
Synapse (Netherlands)
2023-2025
Maastricht University
2019-2024
University of Reading
2021-2023
IRCCS Humanitas Research Hospital
2022-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Wageningen University & Research
2020
Aziende Socio Sanitarie Territoriale Ovest Milanese
2019
Azienda Ospedaliera Ospedale Civile di Legnano
2019
Ospedale Bassini
2016
Abstract Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, clinical scientists to discuss origin potential consequences of thrombo-inflammation etiology, diagnostics, management patients with disease, including myocardial infarction, stroke, peripheral artery disease. This article presents state-of-the-art...
Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or theoretical proteome a representative human platelet. Here, we integrated established proteomes from six cohorts healthy subjects, encompassing 5.2 k proteins, with two novel genome-wide transcriptomes (57.8 mRNAs). For 14.8 protein-coding transcripts, assigned proteins to 21 UniProt-based classes, based on their preferential intracellular localization presumed function. This classified...
Diabetes increases morbidity and mortality in cystic fibrosis (CF) patients, but several studies indicate that also prediabetic status may have a potential impact on both nutrition lung function.To evaluate the effect of glargine clinical course CF patients with early glucose derangements.CF population was screened for tolerance. age >10 yr were fasting hyperglycemia (FH). without FH those <10 occasional evaluated abnormalities basis oral tolerance test and/or continuous monitoring system....
BackgroundEspecially in disease conditions, platelets can encounter activating agents circulation.ObjectivesTo investigate the extent to which previously activated be reactivated and whether in-and reactivation applies different aspects of platelet activation thrombus formation.MethodsShort-and long-term effects glycoprotein VI (GPVI) G protein-coupled receptor (GPCR) stimulation on aggregation potential were compared via flow cytometry plate-based aggregation. Using fluorescence electron...
Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement the signaling collagen receptor glycoprotein (GP)VI, enforced integrin α2β1. Protein tyrosine kinase Syk central in GPVI-induced pathway, leading to elevated cytosolic Ca2+. We aimed determine Syk-mediated thrombogenic activity several peptides and (fibrillar) type I III collagens. High-shear perfusion blood over microspots these...
337 Background: The increasing focus on patient-centered care and the development of precision medicine emphasize need for alternative screening pathways high-risk individuals. Family history is a significant risk factor prostate cancer (PCa), identifying patients with genetic predisposition crucial. discovery germline pathogenic variants (PVs) in DNA repair genes (DRGs) underscores importance dedicated approach. This study aimed to evaluate effectiveness compliance tailored protocol that...
Coronary artery disease (CAD) plaque rupture leads to occlusive thrombosis, causing acute myocardial infarction requiring immediate life-saving treatment. The blood clot is supported by a mesh of fibrin fibres that are generated through the polymerisation fibrin. We recently showed also produces film on surface clots. Our aim was study if occurs intravascularly thrombi from patients with infarction. In this observational study, we recruited 42 ST-elevation (STEMI) and obtained intra-coronary...
In cystic fibrosis (CF), diabetes mellitus (DM) is associated with progression of pulmonary disease and nutritional impairment.To compare oral glucose tolerance test (OGTT) continuous monitoring system (CGMS) in patients CF early derangements.Thirty-two (5-20 years) intermediate values > 7.7 mmol/l during OGTT received a CGMS registration. Patients were classified into those normal (NGT), impaired (IGT) DM, according to at 120 min CGMS. Furthermore BMI z-scores, forced expiratory volume 1...
Abstract Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This considered reversible under specific conditions, allowing a second phase of aggregation. The signaling pathways that differentiate between permanent or transient activation state platelets are poorly elucidated. Objective To explore mechanisms induced by collagen receptor glycoprotein VI (GPVI) protease-activated receptors (PAR) thrombin regulate...
Platelets from healthy donors display heterogeneity in responsiveness to agonists. The response thresholds of platelets are controlled by multiple bioactive molecules, acting as negatively or positively priming substances. Higher circulating levels substances adenosine and succinate, well the occurrence hypercoagulability, have been described for patients with ischaemic heart disease. Here, we present an improved methodology flow cytometric analyses platelet activation characterisation...
Proteoglycans form a heterogeneous family of proteins with covalently bound sulfated glycosaminoglycans. The extracellular matrix proteoglycan perlecan has been proposed to bind the platelet- and megakaryocyte-specific receptor G6bB, co-regulating platelet glycoprotein VI (GPVI) signaling. derived non-sulfate endorepellin was previously shown enhance adhesion via collagen receptor, integrin α2β1. Here, we compared roles other proteoglycans in responses thrombus formation. We used multi-color...
Guidelines indicate that a low-protein diet (LPD) delays dialysis in severe chronic kidney disease (CKD). We assessed the value of these guidelines by performing retrospective analysis our renal clinical practice.The was performed from 1 January 2010 to 31 March 2018 299 CKD Stage 4 patients followed for 70 months collaboration with skilled nutritionist. The included 43 on controlled protein (CPD) 0.8 g/kg/day [estimated glomerular filtration rate (eGFR) 20-30 mL/min/1.73 m2 body surface...
The clinical course of IgA nephropathy (IgAN) and its outcome are extremely variable. Proteinuria at baseline has been considered one the most important risk factors. More recently, mean proteinuria follow-up (time-average proteinuria: TAp) was described as a stronger marker renal survival, suggesting to consider it disease activity response treatment. We evaluated predictors survival in IgAN patients with different degrees dysfunction histological lesions, focusing on role therapy...
Objectives To test the hypothesis of a relationship between specific genetic lesion (T2:ERG) and imaging scores, such as PI-RADS PRI-MUS, to effectiveness these parameters for diagnosis prostate cancer (PCa) clinically significant PCa (csPCa). Materials methods This is prospective study men with suspected enrolled 2016 2019 at high-volume tertiary hospital. Patients underwent systematic US-guided biopsy, plus targeted biopsy if they were presenting &gt;=1 suspicious (PI-RADS&gt;2)...
Platelet and coagulation activation are highly reciprocal processes driven by multi-molecular interactions. Activated platelets secrete several factors expose phosphatidylserine, which supports the of factor proteins. On other hand, cascade generates known ligands for platelet receptors, such as thrombin fibrin. Coagulation (F)Xa, (F)XIIIa activated protein C (APC) can also bind to platelets, but functional consequences unclear. Here, we investigated effects (anti)coagulation on than...
Although an impact of processing on immunogenicity food proteins has clearly been demonstrated, the underlying mechanisms are still unclear. We applied 3 different methods: wet heating (60 °C) and low- or high-temperature (50 °C 130 °C, respectively) dry-heating in absence presence reducing sugars, to β-lactoglobulin (BLG), lysozyme thyroglobulin, which represent dietary with pI molecular weight. Uptake soluble fraction samples was tested two types of, genetically homogeneous,...
Introduction and Aims: To evaluate the efficacy safety of telmisartan combined with clopidogrelin and/or leflunomide for patients lgA nephropathy whether combination therapy surpass in decreasing proteinuria protecting renal function.Methods: We enrolled 400 aged 18-55 years from 13 centers Beijing who had 0.5˜3.5gper day, baseline serum creatinine (SCr) <265.2μmol/L(3mg/ dl).All were eluted by taking 80mg per day 4 weeks then randomly assigned to receive at least 24 treatment + placebo...
342 Background: Pathogenic variants (PVs) in DNA repair genes (DRG), such as BRCA1, BRCA2, ATM, CHEK2, etc., have implications for prostate cancer (PCa) family genetic counselling, testing and risk stratification men. However, understanding how to counsel patients with of unknown significance (VUS) is an unmet clinical need. On the other hand, there necessity cautiously interpret VUS findings bolster evaluations additional evidence pathogenicity. In this study, we aim investigate prevalence...
278 Background: Family history is a major prostate cancer (PCa) risk factor. Pathogenic gene variants (e.g., BRCA1/BRCA2) greatly increase PCa (2.5 to 8.6-fold for <65-year-olds) and affect outcomes. This study assesses an enhanced screening protocol's effectiveness participant compliance. It combines PHI familial cases multiparametric MRI those with pathogenic DNA repair (DRG) variants. Methods: non-profit charity-funded (AIRC - Fondazione AIRC project IG 2020 ID 25027) evaluates...