A5103130153- Total Knee Arthroplasty Outcomes
- Blood transfusion and management
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Venous Thromboembolism Diagnosis and Management
- Wound Healing and Treatments
- Antimicrobial agents and applications
- Bone Tissue Engineering Materials
- Bone and Joint Diseases
- Polymer Surface Interaction Studies
- Bone health and treatments
- Monoclonal and Polyclonal Antibodies Research
- Knee injuries and reconstruction techniques
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Pressure Ulcer Prevention and Management
- Hydrogels: synthesis, properties, applications
- Urinary Tract Infections Management
- Cardiac and Coronary Surgery Techniques
- Burn Injury Management and Outcomes
- Infection Control in Healthcare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Sichuan University
2014-2025
West China Hospital of Sichuan University
2014-2025
Aims The aim of this study was to examine the efficacy and safety multiple boluses intravenous (IV) tranexamic acid (TXA) on hidden blood loss (HBL) inflammatory response following primary total hip arthroplasty (THA). Patients Methods A 150 patients were allocated randomly receive a single bolus 20 mg/kg IV TXA before incision (group A), followed by second 1 g IV-TXA three hours later B) or two six C). All treated using standard peri-operative enhanced recovery protocol. Primary outcomes...
Abstract As cancer is increasingly considered a metabolic disorder, it postulated that serum metabolite profiling can be viable approach for detecting the presence of cancer. By multiplexing mass spectrometry fingerprints from two independent nanostructured matrixes through machine learning highly sensitive detection and high throughput analysis, we report laser desorption/ionization (LDI) spectrometry-based liquid biopsy pan-cancer screening classification. The M ultiplexed N anomaterial- A...
Although dressing blood-contacting devices with robust and synergistic antibacterial antithrombus properties has been explored for several decades, it still remains a great challenge. In order to endow materials remarkable abilities, stable antifouling hydrogel coating was developed via surface-initiated polymerization of sulfobetaine methacrylate acrylic acid on polymeric substrate followed by embedding antimicrobial peptides (AMPs), including WR (sequence: WRWRWR-NH2) or Bac2A...
To develop and validate magnetic resonance imaging (MRI)-based pre-Radiomics delta-Radiomics models for predicting the treatment response of local advanced rectal cancer (LARC) to neoadjuvant chemoradiotherapy (NCRT).Between October 2017 August 2022, 105 LARC NCRT-naïve patients were enrolled in this study. After careful evaluation, data 84 that met inclusion criteria used NCRT models. All received NCRT, post-treatment was evaluated by pathological assessment. We manual segmented volume...
Objective Knee osteoarthritis (OA) patients exhibit greater gait asymmetry than healthy controls. However, in kinematics, kinetics and muscle forces across with different severity levels of knee OA is still unknown. The study aimed to investigate the changes lower limb kinetics, force OA. Methods This a cross‐sectional study. From January 2020 2021, 118 symptomatic radiographic medial were categorized into three groups using Kellgren Lawrence scale (mild: grade 1 2, n = 37; moderate: 3, 31;...
The development of injectable hydrogel dressings which are long-term moisturizing, easy-to-apply, and effectively inhibiting infection inflammatory is essential to promote burn wound repairing. Herein, an with antibacterial, anti-inflammation abilities via multiple reversible interactions between cation guar gum (CG) metallic-polyphenolic nanoparticles (PA-Zn
Wound healing in movable parts, including the joints and neck, remains a critical challenge due to frequent motions poor flexibility of dressings, which may lead mismatching mechanical properties fitting between dressings wounds; thus, increasing risk bacterial infection. This study proposes sprayable zwitterionic antibacterial hydrogel with outstanding desirable adhesion. precursor is fabricated by combining sulfobetaine methacrylate (SBMA) poly(sulfobetaine methacrylate-co-dopamine...
Soft tissue and bone cancers, collectively known as sarcomas, constitute a diverse array of uncommon tumors originating from connective tissues. Among leiomyosarcoma (LMS) is one the most frequently encountered subtypes. This study aims to investigate expression, clinical significance, biological regulation, dysregulation mechanisms extra spindle pole bodies like 1 (ESPL1), gene critical for cell cycle regulation in LMS. Bioinformatics analysis was performed using data The Cancer Genome...
Osteomyelitis is a serious inflammatory disease mostly caused by bacterial infections. It necessary to simultaneously eradicate cells and inhibit inflammation in treating osteomyelitis. Herein, we design an innovative zinc ion (Zn2+)-based nano delivery system for the management of Taking advantage coordination self-assembly Zn2+, quercetin (QU), ε-poly-L-lysine (EPL), Zn2+-containing nanoparticles (denoted as ZQE NPs) are prepared. NPs spherical with amorphous structures. They stable...
Geriatric hip fracture patients are particularly susceptible to blood loss and venous thromboembolism (VTE) during hemiarthroplasty, yet relatively few studies have examined the safety efficacy of tranexamic acid (TXA) in these patients.This cohort study (≥65 years) undergoing hemiarthroplasty between January 2013 September 2016 involved 289 who received 15 mg/kg TXA prior surgery 320 no TXA. All underwent a fast-track program including nutrition, blood, pain management; VTE prophylaxis;...
Glucocorticoids-induced osteonecrosis of the femoral head (GIONFH) is a common refractory disease. In present study, we aimed to synthesize nano-hydroxyapatite-copper-lithium (Cu-Li-nHA) composite porous scaffold promote osteogenesis and angiogenesis functions repair GIONFH by regulating Wnt/β-catenin HIF-1α/VEGF pathways. The physicochemical property was characterized their osteogenic angiogenic effects were tested through serial experimentsin vitroandin vivo. Results showed that 0.25%...
The clinical treatment of wounds with medical cotton gauze often encounters inflammation and excessive immune response triggered by bacterial infections, which can significantly prolong the wound healing process. It is, therefore, great significance to develop functional gauzes broad-spectrum antibacterial anti-inflammatory activities. Herein, we report a convenient, robust, practical strategy functionalize covalently immobilizing plant-derived gallic acids. obtained GA@Gauze exhibits not...
Hydrophilic antifouling coatings based on zwitterionic polymers have been widely applied for the surface modification of bone implants to combat biofilm formation and reduce likelihood implant-related infections. However, their long-term effectiveness is significantly limited by lack effective precise antibacterial activity. Here, a pH-responsive smart coating (PSB/GS coating) was designed robustly fabricated onto titanium-base using facile two-step method. First, dopamine (DA)...
Abstract 5′‐Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncoprotein, the regulatory effects of which have not been well characterized. This study aimed to investigate expression profile and functional regulation NT5DC2 its potential interplay with TEAD4 in leiomyosarcoma (LMS). Bioinformatic analysis was conducted using data from The Cancer Genome Atlas (TCGA) Genotype‐Tissue Expression (GTEx) program. LMS cell lines SK‐LMS‐1 SK‐UT‐1 were used for both vitro vivo analysis. Results...
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes endless pain and poor quality of life in patients. Usage lubricant combined with anti-inflammatory therapy considered reasonable effective approach for the treatment RA. Herein, inspired by glycopeptides, peptide-decorated hyaluronic acid was synthesized, grafted Fmoc-phenylalanine-phenylalanine-COOH (FmocFF) peptide self-assembled β-sheet conformations could induce folding polymer molecular chains to form...
Abstract The Cancer Genome Atlas (TCGA) Research Network confirmed that undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) share a high level of genomic similarities fall into single spectrum tumour. However, no molecular prognostic biomarkers have been identified in UPS/MFS. In this study, by extracting data from TCGA‐Sarcoma (SARC), we explored relapse‐related genes, their value possible mechanisms the dysregulations. After systematic screening, ITGA10 PPP2R2B were...