A5031352697- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Tissue Engineering and Regenerative Medicine
- Cardiac and Coronary Surgery Techniques
- Magnesium Alloys: Properties and Applications
- Cardiac Valve Diseases and Treatments
- Bone Tissue Engineering Materials
- Corrosion Behavior and Inhibition
- Nanoplatforms for cancer theranostics
- Antimicrobial agents and applications
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Orthopaedic implants and arthroplasty
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Advanced Drug Delivery Systems
- Wound Healing and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Antiplatelet Therapy and Cardiovascular Diseases
- Silk-based biomaterials and applications
- Infectious Aortic and Vascular Conditions
- Hydrogels: synthesis, properties, applications
- Protease and Inhibitor Mechanisms
- Hemostasis and retained surgical items
- Molecular Junctions and Nanostructures
Sichuan University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Chengdu University
2018-2021
Southwest Jiaotong University
2018
Abstract Drug-eluting stent implantation suppresses the excessive proliferation of smooth muscle cells to reduce in-stent restenosis. However, efficacy drug-eluting stents remains limited due delayed reendothelialization, impaired intimal remodeling, and potentially increased late Here, we show that a drug-free coating formulation functionalized with tailored recombinant humanized type III collagen exerts one-produces-multi effects in response injured tissue following implantation. We...
Abstract Biodegradable stents have paved the way to treat coronary artery disease. However, rapid reendothelialization is required solve problems of mismatched degradation rates, localized inflammation, and insufficient biocompatibility. Herein, a novel passivated protein‐adsorption coating synthesized by coordination chelation, oxidation, cross‐linking, polymerization, deposition dopamine, (‐)‐epigallocatechin gallate (EGCG), copper ions (Cu 2+ ) using two‐electron oxidation. This exhibits...
Recently, rapid acquisition of antibiotic resistance, increased prevalence antibiotic-resistant bacterial infections, and slow healing infected wound have led to vast difficulties in developing innovative antimicrobial agents obliterate pathogenic bacteria simultaneously accelerate healing. To effectively solve this problem, we designed light-responsive multifunctional nanoparticles with conjugation quaternary ammonium chitosan photosensitizer chlorin e6 (Ce6) merge chemical photodynamic...
Drug-loading hydrogels are promising candidates in the bioengineering research field; nevertheless, hydrophobic drug loading into a hydrophilic carrier system remains unsolved and is full of challenges. In this work, following potential dual interactions between peptides aromatic drugs, we developed potent hybrid hydrogel formation method, namely, "peptide-/drug-directed self-assembly". The were synthesized using polyethylene glycol (PEG)-based Fmoc-FF peptide polyurethane, which curcumin...
Interrelated coagulation and inflammation are impediments to endothelialization, a prerequisite for the long-term function of cardiovascular materials. Here, we proposed self-regulating anticoagulant coating strategy combined with anti-inflammatory capacity, which consisted thrombin-responsive nanogels components. As an anticoagulant, rivaroxaban was encapsulated in cross-linked by thrombin-cleavable peptide released upon trigger environmental thrombin, blocking further cascade. The...
Localized drug delivery from drug-eluting stents (DESs) to target sites provides therapeutic efficacy with minimal systemic toxicity. However, DESs failure may cause thrombosis, delay arterial healing, and impede re-endothelialization. Bivalirudin (BVLD) nitric oxide (NO) promote healing. Nevertheless, it is difficult combine hydrophilic signal molecules hydrophobic antiproliferative drugs while maintaining their bioactivity. Here, we fabricated a micro- nanoscale network assembly consisting...
Atherosclerosis, the principle cause of cardiovascular disease (CVD) worldwide, is mainly characterized by pathological accumulation diseased vascular cells and apoptotic cellular debris. Atherogenesis associated with upregulation CD47, a key antiphagocytic molecule that known to render malignant resistant programmed cell removal, or “efferocytosis.” Here, we have developed platelet membrane-coated mesoporous silicon nanoparticles (PMSN) as drug delivery system target atherosclerotic plaques...
Abstract Long‐term blood‐contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual‐functional surface engineering strategy for CVCs by organic integration endothelium‐mimicking fibrinolytic functions. In proposal, lysine (Lys)/Cu 2+ ‐incorporated zwitterionic polymer coating (defined as PDA/Lys/Cu‐SB) is designed robustly...
As a promising biodegradable metallic material, magnesium (Mg) and its alloys have attracted special attention in the recent decade. However, challenges still remain due to high corrosion rate insufficient biocompatibility after implantation. In this work, we prepare simple versatile green tea phenol–metal induced multilayer conversion coating (Mg2+ incorporated epigallocatechin gallate (EGCG) coating) on alloys' (AZ31) substrate by layer-by-layer (LBL) method. The surface morphology results...
In recent years, valvular heart disease has become a serious threatening human life and is major cause of death worldwide. However, the glutaraldehyde (GLU)-treated biological valves (BHVs) fail to meet all requirements clinical application due disadvantages such as valve thrombus, cytotoxicity, endothelialization difficulty, immune response, calcification. Encouragingly, there are large number carboxyls well few amino groups on surface GLU-treated BHVs that can be modified enhance...
Although dressing blood-contacting devices with robust and synergistic antibacterial antithrombus properties has been explored for several decades, it still remains a great challenge. In order to endow materials remarkable abilities, stable antifouling hydrogel coating was developed via surface-initiated polymerization of sulfobetaine methacrylate acrylic acid on polymeric substrate followed by embedding antimicrobial peptides (AMPs), including WR (sequence: WRWRWR-NH2) or Bac2A...
A conformally adapted all-in-one hydrogel coatings that exhibit both hemocompatibility and bactericidal activity possess the potential for applications in blood-contacting devices.
Abstract Anti-inflammation and anti-coagulation are the primary requirements for cardiovascular stents also widely accepted trajectory multi-functional modification. In this work, we proposed an extracellular matrix (ECM)-mimetic coating with amplified functionalization of recombinant humanized collagen type III (rhCOL III), where biomimetics were driven by structure mimicry component/function mimicry. Briefly, structure-mimic was constructed formation a nanofiber (NF) via polymerization...