A5036689552- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Advanced Image and Video Retrieval Techniques
- Mast cells and histamine
- Ferroptosis and cancer prognosis
- Connective Tissue Growth Factor Research
- Advanced Neural Network Applications
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Polymer composites and self-healing
- Time Series Analysis and Forecasting
- Hepatocellular Carcinoma Treatment and Prognosis
Zhongshan Hospital
2018-2025
Fudan University
2018-2025
The First Affiliated Hospital, Sun Yat-sen University
2018-2025
Sun Yat-sen University
2018-2025
Xinjiang University
2024
Southern University of Science and Technology
2024
Yunnan University
2023
Yunnan Institute of Environmental Sciences
2023
Northwestern Polytechnical University
2022
China University of Mining and Technology
2021
Ionogels are promising material candidates for ionotronics due to their excellent ionic conductivity, stretchability, and thermal stability. However, it is challenging develop 3D printable ionogels with both electrical mechanical properties. Here, we report a highly conductive stretchable nanostructured (CSN) ionogel printing ionotronic sensors. We propose the photopolymerization-induced microphase separation strategy prepare CSN comprising continuous conducting nanochannels intertwined...
Abstract CD73 is a glycosylphosphatidylinositol (GPI)‐anchored protein that attenuates tumour immunity via cooperating with CD39 to generate immunosuppressive adenosine. Therefore, blockade has been incorporated into clinical trials for cancers based on preclinical efficacy. However, the biological role and underlying mechanism of in pancreatic cancer (PC) microenvironment its prognostic impact have not comprehensively studied. In this article, we found expression was up‐regulated PC tissues...
Abstract Lipopolysaccharide (LPS) as an important inflammatory mediator activates the innate/adaptive immune system. The existence of LPS in pancreatic ductal adenocarcinoma (PDAC) has been reported, however, its biological function PDAC remains unclear. Here, we demonstrated that circulating and tumoral was significantly increased by intestinal leakage orthotopic murine model, administration promoted T cell infiltration but exhaustion paradoxically subcutaneous model. By bioinformatic...
Background As an integral part of the tumor microenvironment (TME), tumor-associated neutrophils play a crucial role in development. The objective this study was to investigate plasticity N1 and N2 TME pancreatic ductal adenocarcinoma (PDAC), along with its impact on survival association immune infiltrations. Methods primary validation cohorts including 90 radical resection patients from September 2012 May 2016 29 2018 October 2019, respectively, complete data, were enrolled....
Background: The prognosis of pancreatic carcinoma (PC) remains poor and the American Joint Committee on Cancer (AJCC) 8th staging system for survival prediction in PC patients after curative resection is still limited. Thus, aim this study to refine a valuable prognostic model novel with resection. Methods: data 3,458 used were retrieved from Surveillance, Epidemiology, End Results database registry National Institute. value lymph node ratio (LNR) was analyzed primary cohort nomogram based...
The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor due to the difficulty disease diagnosis and therapy. Immunotherapy has had robust performance against several malignancies, including PDAC. In this study, we aim analyze expression CD8 FoxP3 on T lymphocytes TGF-β in tumor tissues, then possible clinical significance these finding order find a novel effective immunotherapy target PDAC using murine model. A tissue microarray patient samples was stained analyzed for...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, necessitating approaches to improve prognosis. As the mediator of allergic process, mast cells have been found in various cancers and are associated with survival. However, biological behaviors tumor‐associated (TAMCs) remain unclear. Herein, an excessive infiltration TAMCs PDAC demonstrated, which apparently poor survival patients. recruit CXCR2 + MCs into TME, then inhibited ferroptosis, maintained their...
Deep learning technology is one of the key research directions in field machine learning, especially when dealing with high-dimensional and non-linear data prediction tasks, but it can not avoid problem overfitting underfitting models. Taking LSTM neural network as an example, this paper proposes ensemble model based on additive Gaussian process priors. On hand, proposed method uses bootstrap to realize randomization model, so that capture effective information predictor variables from...
The role of CD161 expression on CD8+ T cells in tumor immunology has been explored a few studies, and the clinical significance CD161+CD8+ pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study seeks to clarify prognostic value molecular characteristics linked cell infiltration PDAC. included 186 patients with confirmed PDAC histology after radical resection. was assessed using immunofluorescence staining microarrays. Flow cytometry single-cell RNA sequencing were used evaluate...
Abstract CD73 plays a critical role in the pathogenesis and immune escape pancreatic ductal adenocarcinoma (PDAC). AB680, an exceptionally potent selective inhibitor of CD73, is administered early clinical trial, conjunction with gemcitabine anti‐PD‐1 therapy, for treatment PDAC. Nevertheless, specific therapeutic efficacy immunoregulation within microenvironment AB680 monotherapy PDAC have yet to be fully elucidated. In this study, exhibits significant effect augmenting infiltration...
Background: Patients with pancreatic ductal adenocarcinoma (PDAC) are increasingly receiving systemic neoadjuvant chemotherapy (NAC), particularly those borderline resectable and locally advanced disease. However, the specific role of additional adjuvant (AC) in these patients is unknown. The objective this study to further assess clinical benefit impact AC resected PDAC after NAC. Methods: Data on or without following NAC surgical resection were retrospectively retrieved from Surveillance,...
Pancreatic ductal adenocarcinoma (PDAC) has been widely considered as one of the most lethal malignancies with a 5-year overall survival (OS) rate only 11%.1 Lots efforts have devoted into its early diagnosis, treatment strategies, and pathogenesis, etc. PDAC is characterized excessive desmoplastic tumor abundant immune cells infiltration, mainly including macrophages, T cells, immature myeloid neutrophils. Neutrophils are white blood in regarded homogeneous group past, which belongs to...
Background: The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor. Open distal pancreatosplenectomy (ODPS) is prevalent in the patients early PDAC located body or tail. However, models for relapse survival prediction those are still limited. Postoperative neutrophil-to-lymphocyte rate (poNLR), a novel inflammation-based score, has been formulated to analyze prognostic significance with ODPS. Therefore, this study aims generate valuable nomogram following Methods: We...
Radiofrequency ablation (RFA) is widely used in palliative therapy of malignant cancers. Several studies have shown its applicability and safety for locally advanced pancreatic cancer (LAPC). The objective this study was to modify the current regimen improve therapeutic effect.Immune cell subtypes related cytokines were quantified uncover immune pattern changes post-RFA treatment. Then, high-throughput proteome analysis performed identify differentially expressed proteins associated with...
In this paper, we study the influence of density and water–cement (W/C) ratio on slurry fluidity, compressive strength, water absorption foamed concrete (FC) its mechanism action, with aim proposing an optimal mix for FC to reduce cement usage carbon emissions in construction industry ensure good overall performance FC. experiment, two groups experiments were designed using control variable method. Fluidity uniaxial compression tests showed that when was 600 kg/m3 W/C 0.6, had maximum but...