The underlying mechanisms of methionine adenosyltransferase 2 A (MAT2A)-mediated cervical cancer progression under nutrient stress are largely elusive. Therefore, our study aims to investigate molecular mechanism by which MAT2A-indcued oncogenesis. interaction between MAT2A and programmed cell death protein 6 (PDCD6) in lines was detected immunoprecipitation, immunoblotting mass spectrometric analysis. panel inhibitors that linked responsive kinases were utilized detect related pathways...

Abstract Extracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers. Their physical, chemical and biological characteristics distinguish them unique carriers with specific pharmacokinetic, circulating metabolic, biodistribution patterns in the of therapeutic cargoes. They are critical mediators pathology many diseases, including inflammatory fibrosis, cancer, but they also essential immunomodulation, cancer treatment, infectious defense, tissue repair....

To investigate the association between widespread use of mifepristone in abortions and risk uterine leiomyomas. We conducted a case-control study 305 patients with leiomyomas January 2011 July 2012; 311 women ordinary vaginitis were selected as controls during same period. Data collected by questionnaires (including past history, life menstruation reproductive abortion mifepristone, factors) calculated univariate multivariate conditional logistic regression analyses; odds ratios its 95%...

Rhinovirus (RV) is the most common respiratory virus affecting humans. The majority of asthma deteriorations are triggered by RV infections. However, whether effects single‑ and double‑stranded RNA on deterioration have target genes needs to be further studied. In present study, two datasets (GSE51392 GSE30326) were used screen for differentially expressed (cDEGs). molecular function, signaling pathways, interaction networks, hub genes, key modules regulatory molecules cDEGs systematically...

<title>Abstract</title> An in vivo mouse model of <italic>Clonorchis sinensis</italic> (<italic>C. sinensis</italic>) infection with or without the administration autophagy inhibitor chloroquine (CQ) stimulation was established to assess possible involvement autophagic response during <italic>C. infection. Abnormal liver function observed at four, six, eight weeks post-infection, as indicated by elevated levels ALT/GPT, AST/GOT, TBIL, α-SMA infected group. Our findings activated autophagy,...

Background: Studies have shown that, Shengmai injection (Shengmai decoction) which has been included in the diagnosis and treatment of coronavirus disease 2019 (COVID-19), is effective early patients with severe COVID-19. However, mechanism its intervention stage COVID-19 at molecular level still unclear. Therefore, it necessary to further explore decoction based on network pharmacology. Methods: The Traditional Chinese Medicine Systems Pharmacology, BATMAN, UniProt databases published...

Objective . To use the logistic regression model to evaluate value of ultrasound characteristics in Ovarian‐Adnexal Reporting and Data System lexicon determining ovarian solid component‐containing mass benignancy/malignancy. Methods We retrospectively analyzed data 172 patients with adnexal masses discovered by ultrasound, diagnosis was confirmed postoperative pathological tests from January 2019 December 2021. Thirteen tumor‐related parameters benign malignant tumor groups were selected for...

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel RNA virus that emerged in late 2019 and was responsible for disease (COVID-19). The WHO has declared the COVID-19 world pandemic. most exacerbations of asthma are triggered by viral infections. However, genetic effects on need to be further studied. Results Eighty-eight common differentially expressed genes (cDEGs) were identified datasets GSE147507 GSE30326. Function analysis showed cDEGs antiviral...

Objective To explore the efficacy of transurethral retrograde balloon dilatation through cystoscope for postoperative ureteral stricture in children. Methods 7 cases with definite diagnosis benign on one side, who were treated at intervention and urinary surgery department our hospital between November, 2017 December, 2018, retrospectively analyzed. Among them, 5 male, 2 female. The youngest was 7 months old, oldest 8 years old. They all diagnosed as after laparoscopic ureteropelvis...

The standardized training for public health physicians plays an important role in exploring the cultivation professionals and strengthening construction of service providers. In 2018, National Health Commission China launched a pilot program 10 provinces. This paper clarifies definition physicians, systematically analyzes status quo other countries, articulates design progress perspective Centers Disease Control Prevention, makes some suggestions priorities program, so as to provide...

Abstract Objectives: To identify and reclassify the patients in LN cohort, to further analyze prominent clinical features significance of each cluster patients. Methods: This is a cross-sectional study cohort 635 from Rheumatology Department Xiangya Hospital Central South University. Demographic data, laboratory findings evaluation system include physician’s global assessment SLICC/ACR Damage Index were collected. Using two-step analysis, with similar property identified compared. Results:...