A5023420879- Neonatal Respiratory Health Research
- Neonatal and Maternal Infections
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Infant Nutrition and Health
- Hemodynamic Monitoring and Therapy
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Viral Infections and Immunology Research
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Inhalation and Respiratory Drug Delivery
- Neonatal and fetal brain pathology
- Cancer, Hypoxia, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Asthma and respiratory diseases
Guangdong Medical College
2008-2022
Affiliated Hospital of Guangdong Medical College Hospital
2019-2022
Southern Medical University
2009
Epidemiological studies have shown that elevated concentrations of ambient particulate matter (aerodynamic diameter ≤2.5 μm; PM2.5) correlates with increased incidence asthma. The aim this study was to determine whether PM2.5 participates in the exacerbation asthma.Effects 1, 10 and 100 μg instilled intratracheally ovalbumin (OVA)-sensitized or asthmatic mice were compared.PM2.5 exposure OVA-sensitized especially groups Mch responsiveness a dose-dependent manner. In groups, 1 caused no...
Abstract Background An increasing number of extremely preterm (EP) infants have survived worldwide. However, few data been reported from China. This study was designed to investigate the short-term outcomes EP at discharge in Guangdong province. Methods A total 2051 discharged 26 neonatal intensive care units during 2008–2017 were enrolled. The 2008 2012 collected retrospectively, and 2013 2017 prospectively. Their hospitalization records reviewed. Results During 2008–2017, mean gestational...
Traditional Chinese medicine (TCM) had demonstrated effectiveness in the prevention and control of COVID-19. Statistics showed that Ephedra Glycyrrhiza were frequently used treatment We hypothesized Ephedra-Glycyrrhiza drug pair is a potential choice for Here, 112 active compounds identified from via network pharmacology approach. enrichment analysis these might participate cAMP, PI3K-Akt, JAK-STAT chemokine signaling pathways, which high correlation with respiratory, nervous, blood...
Asthma is a common chronic respiratory disease. In previous study, we found several circulating microRNA signatures associated with childhood asthma and selected miR-3162-3p for subsequent studies. Since the target proteins underlying molecular mechanisms of in etiopathogenesis are not well characterized, designed this study to clarify its role. We employed bioinformatics quantitative PCR methods as first step determine miR-3162-3p, elucidated β-catenin. Luciferase assays western blot...
Abstract With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, China, related studies are rare. The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units Guangdong Province China during 2008–2017 were analyzed. A total 2575 enrolled and overall survival rate was 55.11%. From 2008 to 2017, number increased rapidly 91 466, improved steadily 41.76% 62.02%. Increased is closely (BW), regional...
This study aimed to evaluate the predictive validity of day-1 PELOD-2 and "quick" (qPELOD-2) scores for in-hospital mortality in children with sepsis a pediatric intensive care unit (PICU) developing country.The data 516 diagnosed as were retrospectively analyzed. The divided into survival group non-survival group, according clinical outcome 28 days after admission. Day-1 PELOD-2, qPELOD-2, SOFA (pSOFA), P-MODS collected scored. Receiver operating characteristic (ROC) curves plotted,...
Abstract Enterovirus A-71 (EV-A71) may be fatal, but the natural history, symptoms, and signs are poorly understood. This study aimed to examine history of fatal EV-A71 infection identify symptoms early warning deterioration. was a clinical observational cases treated at five Chinese hospitals between 1 January 2010 31 December 2012. We recorded analysed 91 manifestations in order prognosis indicators. There were 54 cases. Median age 21.5 months (Q1−Q3: 12–36). The median duration from onset...
Neuroblastoma amplified sequence (NBAS)-associated disease has a wide phenotypic spectrum, including infantile liver failure syndrome type 2 (ILFS2, OMIM #616483), short stature with optic nerve atrophy and Pelger-Huët anomaly (SOPH) (OMIM #614800), combined phenotype overlapping ILFS2 SOPH syndrome. The mutation spectra of NBAS its genotype-phenotype correlation among Chinese were not clear.Clinical genetic data retrospectively collected from the medical charts patients biallelic mutations,...
Background: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis 3) was based on the sequential organ failure assessment (SOFA) score. Matics Sanchez-Pinto contrived a SOFA score designed specifically pediatric patients (pSOFA) to evaluate prognosis of children with sepsis according degree dysfunction. Objectives: aim our study predictive validity pSOFA in-hospital mortality in intensive care unit (PICU) developing country. Methods: This single-center...
MicroRNA (miRNA) mimics or antagomirs hold great promise for asthma treatment compared with glucocorticoids as mainstay therapy asthma. But the role of miRNA in regulating asthmatic inflammation is largely unclear. We previously reported that miR-3162-3p peripheral blood children was obviously upregulated to healthy children. This study aimed elucidate pulmonary normal and mice well preliminarily explore potential antagomir treatment. A noninvasive whole-body plethysmograph measured airway...
This study aimed to evaluate the predictive validity of day‐1 PELOD‐2 and “quick” (qPELOD‐2) scores for in‐hospital mortality in children with sepsis a pediatric intensive care unit (PICU) developing country. The data 516 diagnosed as were retrospectively analyzed. divided into survival group non‐survival group, according clinical outcome 28 days after admission. Day‐1 PELOD‐2, qPELOD‐2, SOFA (pSOFA), P‐MODS collected scored. Receiver operating characteristic (ROC) curves plotted, efficiency...
Primary generalized glucocorticoid hypersensitivity (PGGH) is a very rare disease caused by terminal organ to glucocorticoids for which the aetiology unknown. The incidence of PGGH extremely rare, especially in children. To date, literatures about etiology, prognosis and treatment are scarce. Aim study describing cases two Chinese children with infantile-onset one family, whom died who was treated mifepristone. They youngest reported literature.Two siblings were affected this family. main...
Following the recent experimental discovery of a new polarization conversion phenomenon in volume gratings (PVGs), this paper, we investigate its underlying physical mechanisms cholesteric liquid crystal (CLC) reflectors and PVGs. We examine transition eigenstates from circular to linear as incident angle deviates helical axis, which originates such an anomalous effect. While enables PVGs double in-coupling efficiency brightness uniformity waveguide-based augmented reality (AR) displays, it...
Background: Studies have shown that, Shengmai injection (Shengmai decoction) which has been included in the diagnosis and treatment of coronavirus disease 2019 (COVID-19), is effective early patients with severe COVID-19. However, mechanism its intervention stage COVID-19 at molecular level still unclear. Therefore, it necessary to further explore decoction based on network pharmacology. Methods: The Traditional Chinese Medicine Systems Pharmacology, BATMAN, UniProt databases published...