A5101600399- Viral Infections and Immunology Research
- Infectious Encephalopathies and Encephalitis
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Whipple's Disease and Interleukins
- Fetal and Pediatric Neurological Disorders
- Viral Infections and Vectors
- RNA Research and Splicing
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Respiratory viral infections research
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Blood transfusion and management
- Metabolism and Genetic Disorders
- Galectins and Cancer Biology
Hangzhou Normal University
2025
Guangzhou Medical University
2012-2024
Xintai People's Hospital
2024
Guangzhou Women and Children Medical Center
2016-2023
Foshan University
2023
Baoshan College
2022
Gansu University of Traditional Chinese Medicine
2016-2022
Abstract Circular RNAs (circRNAs) have confirmed to participate in diverse biological functions cancer. However, the expression patterns of circRNAs on hepatocellular carcinoma (HCC) remains unclear. In present study, we clarified that hsa_circRNA_104348 was dramatically upregulated HCC tissues and cells. Patients with displaying high level possessed poor prognosis. Has_circ_104348 facilitated proliferation, migration, invasion, meanwhile suppressed apoptosis cell. Furthermore, directly...
Objective To explore the inner experiences and needs of parents adolescents with depression in caregiving process, to understand problems they encounter, provide precise intervention support strategies for this group from a positive psychology orientation. Methods Use qualitative research methods, semi-structured interviews were conducted 12 depression, selected December 2022 October 2023. Colaizzi′s seven-step analysis method was used extract themes. Results The parental experience can be...
BACKGROUND:Although influenza primarily affects the respiratory system, it can cause severe neurological complications, especially in younger children, but knowledge about early indicators of acute necrotizing encephalopathy (ANE) is limited. The main purpose this article to summarize clinical characteristics, diagnosis, and treatment complications identify factors associated with ANE. MATERIAL AND METHODS:This was a retrospective study children confirmed treated between 01/2014 12/2019 at...
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), poses an unprecedented threat to human health since late 2019. Notably, the progression of is associated with impaired antiviral interferon (IFN) responses. Although multiple viral proteins were identified as potential IFN antagonists, underlying molecular mechanisms remain be fully elucidated. In this study, we firstly demonstrate that SARS‐CoV‐2 NSP13 protein robustly...
Autophagy is emerging as a critical player in host defense against diverse infections, addition to its conserved function maintain cellular homeostasis. Strikingly, some pathogens have evolved strategies evade, subvert or exploit different steps of the autophagy pathway for their lifecycles. Here, we present new viral mechanism manipulating own benefit with severe fever thrombocytopenia syndrome bunyavirus (SFTSV, an high-pathogenic virus) model. SFTSV infection triggers autophagy, leading...
Enterovirus 71 (EV-A71) shows a potential of rapid death, but the natural history infection is poorly known. This study aimed to examine EV-A71 infection. was prospective longitudinal observational performed between January 1st and October 31st, 2012, at three hospitals in Guangdong, China. Subjects with positive RNA laboratory test results were included. Disease progression documented MRI, autopsies, follow-up. Symptoms/signs association risk death analyzed. Among 288 patients, neurologic...
Enterovirus 71 (EV71) accounts for the majority of hand, foot and mouth disease‑related deaths due to fatal neurological complications. EV71 structural viral protein 1 (VP1) promotes replication by inducing autophagy in neuron cells, but effect VP1 on myelin cells is unclear. The present study aimed investigate role mechanism mouse Schwann cells. An VP1‑expressing vector (pEGFP‑C3‑VP1) was generated transfected into Transmission electron microscopy western blot analysis...
Objectives: To summarize the characteristics and research progress of influenza-associated brain complications in children provide references for early diagnosis protection treatment. Methods: Studied published articles neurocomplications from PubMed summarizes them epidemiology, clinical manifestations, treatment, basic progress. Results: Common flu-children include febrile seizures, encephalopathy (IAE), acute or post-influenza encephalitis, most severe condition is necrotizing (ANE)....
Idebenone, a mitochondrial regulator, has exhibited anti-cancer activity in neurogenic and prostate tumor cells; however, its efficacy specific targets the treatment of triple-negative breast cancer (TNBC) remain unclear. This study aims to evaluate potential Idebenone as therapeutic agent for TNBC. TNBC cell lines Xenograft mouse models were used assess effect on both vitro vivo. To investigate underlying mechanism Idebenone's TNBC, viability assay, transwell invasion cycle analysis,...
Cancer stem cells (CSCs) play important roles in occurrence, development, recurrence and metastasis of cancer.Isolation identification CSCs have been performed from some cancer tissues or cells.In this paper, human lung adenocarcinoma were induced isolated SPC-A1 their characteristics determined.SPC-A1 cultured serum-free medium epidermal growth factor basic fibroblast added into the to induce formation multicellular tumor spheroids.The results showed that floating spheroids (named...
Abstract Enterovirus A-71 (EV-A71) may be fatal, but the natural history, symptoms, and signs are poorly understood. This study aimed to examine history of fatal EV-A71 infection identify symptoms early warning deterioration. was a clinical observational cases treated at five Chinese hospitals between 1 January 2010 31 December 2012. We recorded analysed 91 manifestations in order prognosis indicators. There were 54 cases. Median age 21.5 months (Q1−Q3: 12–36). The median duration from onset...
Among the neurological complications of influenza in children, most severe is acute necrotizing encephalopathy (ANE), with a high mortality rate and sequelae. ANE characterized by rapid progression to death within 1-2 days from onset. However, knowledge about early diagnosis limited, which often misdiagnosed as simple seizures/convulsions or mild influenza-associated (IAE).
BACKGROUND:This study summarizes the characteristics of children screened for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and reports case 1 child who was diagnosed with SARS-CoV-2 in Guangzhou Women Children's Medical Center cases his family members. MATERIAL AND METHODS:The medical records 159 were admitted to our hospital from January 23 March 20, 2020, retrospectively analyzed. Samples pharyngeal or/and anal swabs subjected reverse-transcription polymerase...
Acute necrotizing encephalopathy (ANE) is a rare but severe and associated with high morbidity mortality. We aimed to analyze compare the clinical features predictive indicators of pediatric ANE.This retrospective study included children ANE diagnosed at Guangzhou Women Children's Medical Center between November 2018 January 2020. Pediatric patients' information, including characteristics, laboratory tests, neuroelectrophysiology brain magnetic resonance imaging (MRI) findings, MRI score,...
Abstract Objective Explore the clinical characteristics and prognosis of children with norovirus (NoV)‐associated benign convulsions mild gastroenteritis (CwG). Methods We retrospectively analyzed Clinical laboratory data NoV‐associated CwG admitted to emergency department Guangzhou Children's Hospital between January 2019 2020. And patients were followed up for 23–36 months. Results There are 49 cases met criteria. Vomiting was first symptom in 31 (63.3%) patients, vomiting could be main or...
BACKGROUND:Influenza-associated acute necrotizing encephalopathy (IANE) can be lethal and disabling have a sudden onset deteriorate rapidly but lacks early diagnostic indicators. We aimed to examine the clinical indicators in children with IANE. MATERIAL AND METHODS:Acute influenza patients were grouped according their manifestations: flu alone (FA), febrile seizure (FS), influenza-associated (IAE), The features, biomarkers, neuroelectrophysiological results, neuroimaging examination results...
Background: During Enterovirus type 71 (EV71) infection, the structural viral protein 1 (VP1) activates endoplasmic reticulum (ER) stress associated with peripheral myelin 22 (PMP22) accumulation and induces autophagy.However, specific mechanism behind this process remains elusive.Methods: In research, we used VP1-overexpressing mouse Schwann cells (SCs) models co-transfected a PMP22 silencing or Autocrine motility factor receptor (AMFR/gp78) overexpressing vector to explore regulation of...
Abstract Background To describe the characteristics of pediatric patients with severe COVID‐19 in China and identify clinical variables associated cardiovascular involvement, neurological complications, disease prognosis. Methods A retrospective surveillance study were conducted from December 1 to 31, 2022, Guangzhou Women Children's Medical Center. Clinical laboratory abstracted by medical record review further analyzed according different manifestations. Results total 30 children (median...
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 can pathological damage nervous system, such as neuronal vacuolar degeneration, shrinkage some neurons, edema brain tissues hippocampus, and a decreased number Nissl bodies infarction area. Also, caused apparent structural to Schwann cells, including cytoplasmic organelles severe rough endoplasmic...
Little is known about the particular changes of N6-methyladenosine (m6A) RNA methylation in enterovirus (EV) infection among children with neurologic symptoms. Here, we determined characterization EV associated m6A this population. A prospective cohort study was conducted from 2018/2 to 2019/12 at Guangzhou Women and Children's Medical Center. We included infected without neurological High-throughput m(6)A-RNA immunoprecipitation sequencing (MeRIP-seq) RNA-seq analysis were used evaluate...