A5037012192- Sexual Differentiation and Disorders
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Viral Infections and Vectors
- interferon and immune responses
- Magnetism in coordination complexes
- Alkaline Phosphatase Research Studies
- Natural product bioactivities and synthesis
- Urological Disorders and Treatments
- Testicular diseases and treatments
- Biosensors and Analytical Detection
- Hormonal and reproductive studies
- SARS-CoV-2 and COVID-19 Research
- Selenium in Biological Systems
- Heterotopic Ossification and Related Conditions
- RNA Interference and Gene Delivery
- Synthesis of Organic Compounds
- Bioactive natural compounds
- Gold and Silver Nanoparticles Synthesis and Applications
- Mosquito-borne diseases and control
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hormonal Regulation and Hypertension
Chongqing Medical University
2019-2024
Children's Hospital of Chongqing Medical University
2019-2024
University of Chinese Academy of Sciences
2022-2023
Wuhan Institute of Virology
2022-2023
Chinese Academy of Sciences
2023
Hebei Normal University
2022
China International Science and Technology Cooperation
2019
Shenzhen University
2013-2014
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), poses an unprecedented threat to human health since late 2019. Notably, the progression of is associated with impaired antiviral interferon (IFN) responses. Although multiple viral proteins were identified as potential IFN antagonists, underlying molecular mechanisms remain be fully elucidated. In this study, we firstly demonstrate that SARS‐CoV‐2 NSP13 protein robustly...
Individuals with 17-beta-hydroxysteroid dehydrogenase type 3 (17β-HSD3) deficiency face a multitude of challenges, primarily concerning genital appearance, potential malignancy risks, and fertility issues. This study reports our findings from an investigation involving five individuals affected by 17β-HSD3 deficiency, ranging in age pre-adolescence to adolescence. Notably, we identified four previously unreported mutations these subjects. Our included comprehensive evaluation determine the...
Autophagy is emerging as a critical player in host defense against diverse infections, addition to its conserved function maintain cellular homeostasis. Strikingly, some pathogens have evolved strategies evade, subvert or exploit different steps of the autophagy pathway for their lifecycles. Here, we present new viral mechanism manipulating own benefit with severe fever thrombocytopenia syndrome bunyavirus (SFTSV, an high-pathogenic virus) model. SFTSV infection triggers autophagy, leading...
Background. 3β-HSD deficiency is a rare type of congenital adrenal hyperplasia (CAH), which caused by HSD3B2 gene mutations.Objectives.In order to improve the understanding and diagnosis disease, we analyzed summarized clinical characteristics, genetic variants treatment for 3 children with in this study. Materials methods.A summary data, hormone levels (17-hydroxyprogesterone, adrenocorticotropic hormone, cortisol, testosterone, dehydroepiandrosterone, androstenedione, renin, aldosterone),...
Hypophosphatasia (HPP) is a rare hereditary disorder characterized by defective bone and tooth mineralization caused mutations in the alkaline phosphatase (ALPL) gene encoding tissue-nonspecific (TNSALP). Here we performed clinical molecular studies on 5 HPP children to investigate pathogenic mechanisms of ALPL variants.Clinical genetic analyses were children, loci where variants identified. Plasmids containing relevant constructed. The cellular investigated immunofluorescence, enzyme...
BACKGROUND Osteosarcoma is a common malignant tumor of musculoskeletal stromal cells. clinical behavior depends mostly on the histologic grade, site primary tumor, response to chemotherapy, and presence pulmonary metastases. The aim this study was knockout SHOX CNE9/10 in U2OS osteosarcoma cells analyze effects cell growth apoptosis. MATERIAL AND METHODS with CNE9 CNE10 were established via CRISPR/Cas9 system. Sanger sequencing used detect success knockdown experiment. Western blotting...
Surface enhanced Raman spectroscopy (SERS), as a molecule-specific method using plasmonic nanostructures to significantly enhance signal intensity, has been employed in various fields. In our study, we investigated the size effect of gold nanoparticles (Au NPs) on surface plasmon response by finite-difference time-domain (FDTD) simulation. addition, SERS experiments, same concentrations crystal violet (CV), were also carried out confirm simulation results. On this basis, citrate-stabilized...
A novel ligand, diethylenetriamine-N,N′,N″-tri(acetyl-p-hydroxybenzoyl hydrazine)-N,N″-bisacetic acid, and its three soluble non-ion transition metal complexes, ML· nH2O (M = Mn, n 4; M Co, Ni, 2) have been synthesized characterized on the basis of elemental analysis, molar conductivities, 1H NMR, FAB-MS, TG-DTA IR methods. In addition, relaxivity complexes are determined, The (R1) MnL, CoL, NiL, Gd(DTPA)2– used as control 6.33, 2.71, 2.60, 4.34L·mmol−1·s−1, respectively. spin-lattice MnL...
Abstract Background: Defects in conserved non-coding elements (CNEs) are associated with a large number of genetic diseases. The short-chain homeobox gene (SHOX) is regulated by different CNEs the upstream and downstream, these can act as enhancers homeopathic regulatory elements. Abnormal downstream SHOX result short stature phenotypes. Methods: This study screened all enhancer action PAR1 region gene, which CNE10 CNE11 have not been reported internationally. We investigated relationship...