A5101967133- RNA modifications and cancer
- RNA Research and Splicing
- RNA regulation and disease
- Viral Infections and Immunology Research
- HVDC Systems and Fault Protection
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
South China Agricultural University
2025
Guangzhou Medical University
2021-2024
Guangzhou Women and Children Medical Center
2021
ABSTRACT Enterovirus A71 (EV-A71 or EV-71) is an RNA virus that causes hand, foot and mouse disease in children. The N6-methyladenosine (m6A) of a common modification involved various biological events. METTL3 m6A methyltransferase regulates EV-71 replication. infection induces autophagy, which also promotes In this study, we explored the role infection-induced autophagy. We constructed lentivirus expressing METTL3-specific shRNA knocked down endogenous Schwann cells. infected normal cells...
Background: During Enterovirus type 71 (EV71) infection, the structural viral protein 1 (VP1) activates endoplasmic reticulum (ER) stress associated with peripheral myelin 22 (PMP22) accumulation and induces autophagy.However, specific mechanism behind this process remains elusive.Methods: In research, we used VP1-overexpressing mouse Schwann cells (SCs) models co-transfected a PMP22 silencing or Autocrine motility factor receptor (AMFR/gp78) overexpressing vector to explore regulation of...
Little is known about the particular changes of N6-methyladenosine (m6A) RNA methylation in enterovirus (EV) infection among children with neurologic symptoms. Here, we determined characterization EV associated m6A this population. A prospective cohort study was conducted from 2018/2 to 2019/12 at Guangzhou Women and Children's Medical Center. We included infected without neurological High-throughput m(6)A-RNA immunoprecipitation sequencing (MeRIP-seq) RNA-seq analysis were used evaluate...
Abstract Objective Enterovirus 71 (EV71), one of the enteroviruses responsible for hand, foot and mouth disease (HFMD), can cause severe neurologic diseases such as brainstem encephalitis demyelination. The molecular mechanism demyelination is still not fully understood. This study aims to investigate how EV71 structural viral protein 1, VP1 act on host cellular pathways in mouse Schwann cells. Methods An VP1-expressing vector was generated transfected into cells (MSCs). Selective mRNA...