A5100730100- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Nerve injury and regeneration
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Machine Learning in Healthcare
- Intracerebral and Subarachnoid Hemorrhage Research
- Biochemical Analysis and Sensing Techniques
- Sepsis Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Antiplatelet Therapy and Cardiovascular Diseases
- Invertebrate Immune Response Mechanisms
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- Diabetes Treatment and Management
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Functional Brain Connectivity Studies
- Adipokines, Inflammation, and Metabolic Diseases
Beijing Tian Tan Hospital
2018-2025
Capital Medical University
2018-2025
National Clinical Research Center for Digestive Diseases
2019-2025
Peking University People's Hospital
2021-2025
Maternal and Child Health Hospital of Sichuan Province
2022-2025
Central South University
2022-2024
Fudan University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2016-2024
Huaihua University
2024
Nanfang College Guangzhou
2024
Abstract Objective: Pathological findings in neonatal brain injury associated with preterm birth include focal and/or diffuse white matter (WMI). Despite the heterogeneous nature of this condition, reactive astrogliosis and microgliosis are frequently observed. Thus, molecular mechanisms by which glia activation contribute to WMI were investigated. Methods: Postmortem brains investigated identify features astrocytes. The contribution was further tested a mouse model genetically engineered...
ABSTRACT Although the immune system may provide early protection against cancer, tumors exploit healing arm of to enhance their growth and metastasis. For example, myeloid derived suppressor cells (MDSCs) are thought promote tumor by several mechanisms, including suppression T cell activity. It has been suggested that STAT3 activation in modulates multiple aspects MDSC physiology, expansion Whereas most animal studies investigating immunology have used implants, we transgenic mice (Smo*)...
The effect of indirect revascularization to improve cerebral perfusion for moyamoya disease (MMD) is based on ingrowth new vessels into the cortical brain. Preoperative indicators neoangiogenesis would be helpful selection appropriate procedures MMD patients but have not yet been investigated. Our study aimed identify potential predictors neovascularization after bypass surgery.
This study introduces a novel Transformer-based time-series framework designed to revolutionize risk stratification in Intensive Care Units (ICUs) by predicting patient outcomes with high temporal precision. Leveraging sequential data from the eICU database, our two-stage architecture dynamically captures evolving health trajectories throughout patient's ICU stay, enabling real-time identification of high-risk individuals and actionable insights for personalized interventions. The model...
Background To develop an artificial intelligence system that can accurately identify acute non-traumatic intracranial hemorrhage (ICH) etiology (aneurysms, hypertensive hemorrhage, arteriovenous malformation (AVM), Moyamoya disease (MMD), cavernous (CM), or other causes) based on non-contrast computed tomography (NCCT) scans and investigate whether clinicians benefit from it in a diagnostic setting. Methods The deep learning model was developed with 1,868 eligible NCCT ICH collected between...
Objective: Extracranial-intracranial bypass is currently recognized as the optimal treatment for hemorrhagic-type moyamoya disease (MMD) which reduces incidence of rebleeding. Recent studies have reported advantage combined over direct general MMD patients, however, effect and surgery specifically had not been investigated yet. Methods: Hemorrhagic-type patients who underwent with complete clinical radiological documentation from a multicenter cohort between 2009 2017 were retrospectively...
Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of chloride (LiCl) in a rat model alleviated pathological inhibited expression tumor necrosis factor α, interleukin-6, interleukin 1 β. pyroptosis reduced inflammation inhibiting Caspase-1 expression, reducing response, activation Nod-like receptor protein 3 inflammasome. We...
Ghrelin regulates body weight, food intake, and blood glucose. It also insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of the growth hormone secretagogue's receptor (GHSR). not only antagonizes stimulation GHSR by ghrelin but inhibits constitutive activation as an inverse agonist. Type 2 diabetes (T2D) patients have endocrine disorders with metabolic imbalance. Plasma levels may be changed in obese T2D patients. However, there no report yet on...
Increasing evidence suggests that secondary injury after diffuse axonal (DAI) damages more axons than the initial insult, but underlying mechanisms of this phenomenon are not fully understood. Recent studies show toll-like receptor 4 (TLR4) plays a critical role in promoting adaptive immune responses and have been shown to be associated with brain damage. The purpose study was investigate TLR4 signalling pathway cortices DAI rats. mainly localized microglial cells neurons, levels downstream...
Sepsis is a serious syndrome that caused by an unbalanced host inflammatory response to infection. The cytokine network plays pivotal role in the orchestration of during sepsis. IL-26 emerging proinflammatory member IL-10 family with multifaceted actions disorders. However, its pathogenesis sepsis remains unknown.Serum level was measured and analyzed 52 septic patients sampled on day intensive care unit (ICU) admission, 18 non-septic ICU patient controls, 30 healthy volunteers. In addition,...
Traumatic brain injury (TBI) is the leading cause of death in young adults and main mortality disability across all ages worldwide. We previously analyzed expression profile data TBI models obtained from Gene Expression Omnibus (GEO) database found that seripina3n mRNA was markedly upregulated acute phase four sets, indicating serpina3n may be involved pathophysiological process TBI. Therefore, we further investigated biological role molecular mechanism traumatic this study. As a result,...
Abstract Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of internal carotid arteries formation compensatory collateral vessels. The etiology MMD remains enigmatic, making diagnosis management challenging. MOYAOMICS project was initiated to investigate molecular underpinnings explore potential diagnostic therapeutic strategies. Methods employs multidisciplinary approach, integrating various omics technologies,...
Objectives: This study aimed to compare the postoperative risks and long-term effects between direct bypass surgery (DB) indirect (IB) for pediatric patients with ischemic-type moyamoya disease (MMD). Method: Pediatric (under or equal 18 years old) who were diagnosed as MMD given surgical treatments at our center 2009 2015 retrospectively reviewed from a prospective database. hemorrhagic-type those did not undergo digital subtraction angiography (DSA) excluded. Patients underwent DB matched...
Objective. Transcranial magnetic stimulation-electroencephalogram (TMS-EEG) technology has played an increasingly important role in the field of neuroscience, and closed loop TMS also been gradually concerned. However, characteristics closed-loop TMS-EEG were few discussed. To study dependence EEG reactivity on cortical oscillation phase under stimulation, we explored detail induced by contingent occipital alpha phase.Approach.By collecting 30 healthy volunteers' data, verified real-time...
Background: Multiple studies have revealed that Traditional Chinese Medicine (TCM) prescriptions can provide protective effect on the cardiovascular system, increase heart rate and relieve symptoms of patients with bradyarrhythmia. In China, TCM treatment bradyarrhythmia is very common, which also an effective complementary therapy. order to further understand application medicines in bradyarrhythmia, we analyzed medication rules for by data mining methods based previous clinical studies....