A5018932172- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Caveolin-1 and cellular processes
- Axon Guidance and Neuronal Signaling
- Anesthesia and Neurotoxicity Research
- Ion Channels and Receptors
- Traumatic Brain Injury Research
- Heme Oxygenase-1 and Carbon Monoxide
- Pain Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Inflammasome and immune disorders
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Immune Response and Inflammation
- Nerve injury and regeneration
- Nephrotoxicity and Medicinal Plants
- Brain Metastases and Treatment
First Affiliated Hospital of Xi'an Jiaotong University
2013-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2020
Xi'an Jiaotong University
2012-2015
Northwest University
2008
High-mobility group box 1 (HMGB1), a nuclear protein that has endogenous cytokine-like activity, is involved in several neurological diseases by mediating inflammatory response. In this study, lateral head rotation device was used to establish rat diffuse axonal injury (DAI) model. The dynamic expression of HMGB1, apoptosis-associated proteins, and proinflammatory cytokines were detected Western blot, neuronal apoptosis observed TUNEL staining. extracellular release HMGB1 the accumulation β...
Early brain injury (EBI) plays a key role in determining the prognosis of patients suffering from subarachnoid hemorrhage (SAH). Resveratrol, natural polyphenol, serves neuroprotection function on EBI after SAH. However, potential mechanism resveratrol remains to be elucidated. Akt, also known as protein kinase B, and mammalian target rapamycin (mTOR), downstream play roles cell survival apoptosis, cycle regulation, cellular homeostasis. In present study, we examined effect their...
Diffuse axonal injury (DAI) accounts for more than 50% of all traumatic brain injury. In response to the mechanical damage associated with DAI, abnormal proteins produced in neurons and axons, namely, β-APP p-tau, induce endoplasmic reticulum (ER) stress. Curcumin, a major component extracted from rhizome Curcuma longa, has shown potent anti-inflammatory, antioxidant, anti-infection, antitumor activity previous studies. Moreover, curcumin is an activator nuclear factor-erythroid 2-related...
Increasing evidence suggests that secondary injury after diffuse axonal (DAI) damages more axons than the initial insult, but underlying mechanisms of this phenomenon are not fully understood. Recent studies show toll-like receptor 4 (TLR4) plays a critical role in promoting adaptive immune responses and have been shown to be associated with brain damage. The purpose study was investigate TLR4 signalling pathway cortices DAI rats. mainly localized microglial cells neurons, levels downstream...
Ca²⁺ overload is considered to be the most important ion imbalance in neuronal injury. Store-operated entry has been suggested a significant mechanism of excessive influx many cells. The role store-operated ischemic injury yet elucidated. aim this study was assess calcium channel (SOCC) proteins involved with induction delayed death after global ischemia rats. A transient RNA interference model rats established determine SOCC-induced death. We found that STIM1 and ORAI1 expression...
Regarding the determination of biomechanical parameters in a reliable vitro cell model for diffuse axonal injury (DAI), our study aimed to demonstrate connections between those and secondary axotomy through examination morphological alterations under variety traumatic conditions. An DAI was established primary cultured mouse neurons by uniaxial mechanical stretching non-myelinated axons various conditions: strain (ε) = 5, 10, 20, 50%; time (t) 500, 100, 20 ms; rate ranging 0.1 25 s-1. Axonal...
Traumatic brain injury (TBI) is the leading cause of death in young adults and main mortality disability across all ages worldwide. We previously analyzed expression profile data TBI models obtained from Gene Expression Omnibus (GEO) database found that seripina3n mRNA was markedly upregulated acute phase four sets, indicating serpina3n may be involved pathophysiological process TBI. Therefore, we further investigated biological role molecular mechanism traumatic this study. As a result,...
Y-box binding protein 1 (YB-1) is manifested as its involvement in cell proliferation and differentiation malignant transformation. Overexpression of YB-1 associated with glioma progression patient survival. The aim this study to investigate the influence knockdown on reveal mechanisms growth, migration, apoptosis. It was found that decreased mRNA levels U251 cells. significantly inhibited proliferation, colony formation, migration vitro tumor growth vivo. Proteome phosphoproteome data...
The purpose of this study is to evaluate the effectiveness gamma knife radiosurgery (GKRS) in treatment pineal region tumors (PRTs). We retrospectively reviewed 147 cases PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60.5–100.1). local tumor control rates (LTCRs) overall survival were calculated results treatment. At 2 after GKRS, volume significantly reduced 91 (61.9 %). 6 months, average 4.2 cm3 as compared 8.47 before...
Diffuse axonal injury (DAI) is the most common and significant pathological features of traumatic brain (TBI). However, there are still no effective drugs to combat formation progression DAI in affected individuals. FK506, also known as tacrolimus, an immunosuppressive drug, which widely used transplantation medicine for reduction allograft rejection. Previous studies have identified that FK506 may play important role nerve protective effect central nervous system. In present study,...
Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, reduce the loss abnormal phosphorylation tau. In present study, intraperitoneal injection significantly reduced protein hyperphosphorylated tau (phosphorylated at Ser(404)(p-tau (S(404))), it increased...
We have previously demonstrated that inflammation induced by toll-like receptors (TLRs) 2/4 exert cerebral deleterious effects after diffuse axonal injury (DAI); however, the underlying mechanisms are not fully understood. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in inflammatory responses. The purpose of this study was to investigate role MIF TLRs cortices DAI rats.The rat model established head rotational acceleration and confirmed β-APP, HE,...