A5038513425- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
- Cerebrovascular and genetic disorders
- Pregnancy and preeclampsia studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Heart Disease Studies
- Glioma Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Acute Ischemic Stroke Management
- Folate and B Vitamins Research
- Advanced Neuroimaging Techniques and Applications
- Connective tissue disorders research
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Plant Disease Resistance and Genetics
- Turfgrass Adaptation and Management
- Cerebrospinal fluid and hydrocephalus
- Barrier Structure and Function Studies
- RNA regulation and disease
- Neurological Disease Mechanisms and Treatments
- Metalloenzymes and iron-sulfur proteins
- Effects of Radiation Exposure
National Clinical Research Center for Digestive Diseases
2016-2025
Chinese Institute for Brain Research
2016-2025
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Beijing Institute of Neurosurgery
2018-2025
Gansu Agricultural University
2022-2023
Capital University
2021
Oxford University Press (United Kingdom)
2018
China University of Geosciences (Beijing)
2014-2015
Beijing Anzhen Hospital
2013-2015
OBJECT The aim of this study was to describe the baseline clinical features and long-term outcomes patients with moyamoya disease (MMD) based on a 25-year period at single center in China. METHODS Data obtained 528 consecutive MMD treated authors' hospital from 1984 2010 were reviewed retrospectively. Events transient ischemic attack, new infarction, hemorrhage included. Kaplan-Meier risk stroke calculated. RESULTS mean (± SD) patient age 26 ± 13 years (range 2–67 years), female/male ratio...
<h3>Objective</h3> To investigate the long term outcomes after conservative and surgical treatment for haemorrhagic moyamoya disease. <h3>Methods</h3> 97 consecutive patients with disease from 1997 to 2009 were enrolled in this study (mean age 31±10 years; range 5–56 years). We reviewed clinical charts radiographs of at first bleeding episode. Follow-up was obtained prospectively by questionnaires radiographic examinations. Outcomes compared based on initial (conservative vs surgical)....
<h3>Objective:</h3> To determine whether the risk of arteriovenous malformation (AVM) rupture is increased during pregnancy and puerperium. <h3>Methods:</h3> Participants included 979 female patients with intracranial AVM admitted to Beijing Tiantan Hospital between 1960 2010. Two neurosurgery residents reviewed medical records for each case. Of them, 393 ruptured 18 40 years age were used case-crossover analysis. Number children born clinical information puerperium retrieved identify...
Abstract Background Moyamoya disease (MMD) stands as a prominent cause of stroke among children and adolescents in East Asian populations. Although growing body evidence suggests that dysregulated inflammation autoimmune responses might contribute to the development MMD, comprehensive detailed understanding alterations circulating immune cells associated with MMD remains elusive. Methods In this study, we employed combination single‐cell RNA sequencing (scRNA‐seq), mass cytometry...
OBJECTIVE Bypass surgery is the most common treatment for moyamoya disease (MMD), but there controversy over which surgical modality best. The objective of this study was to evaluate clinical outcome patients with MMD after undergoing different modalities. METHODS A series 696 consecutive treated between June 2009 and May 2015 were screened in prospective cohort study. Patients who did not undergo revascularization surgeries those underwent modalities bilateral hemispheres excluded. Finally,...
Background and Purpose— Evidence on the natural history of hemorrhagic moyamoya disease is still insufficient. We investigated incidence recurrent intracranial bleeding, mortality, risk factors for rebleeding in patients with disease. Methods— A total 128 conservatively managed presentation complete follow-up data were included. Recurrent hemorrhages during long-term documented. Annual cumulative rate bleeding was generated via Kaplan-Meier survival analysis, analyzed using logistic...
The cause of moyamoya disease (MMD) remains unknown. We aimed to investigate the association between modifiable risk factors and MMD in a prospective, case-control study.Clinical laboratory characteristics were evaluated consecutively recruited adult patients with age-matched healthy control individuals. potential for estimated by logistic regression analysis.Our prospective study included 138 subjects. Logistic analyses showed that increased body mass index (odds ratio [OR], 1.121 [95% CI,...
OBJECTIVE The optimal surgical modality for moyamoya disease (MMD) remains unclear. aim of this study was to compare the effects direct bypass (DB) and indirect (IB) in treatment adult ischemic-type MMD. METHODS Adult patients with MMD who underwent either DB or IB from 2009 2015 were identified retrospectively a prospective database. Patients lost follow-up period less than 12 months excluded. Recurrent stroke events modified Rankin Scale (mRS) scores at last compared between 2 groups after...
Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients 99 healthy controls (HCs). Clinical characteristics network topology were analyzed. Compared to HCs, exhibited decreased clustering coefficient (Cp) (P = 0.006) local efficiency (Eloc) 0.013). Ischemic showed Eloc increased characteristic path length (Lp) compared asymptomatic hemorrhagic < 0.001,...
Background The mechanisms driving the progression of moyamoya disease (MMD) remain unrecognized. There is evidence suggesting that genetic and environmental factors may be associated with intracranial artery stenosis. Here, we aimed to investigate characteristics infectious exposure association RNF213 (RING finger protein 213) variant burden (IB) stenosis MMD. Methods Results We prospectively recruited 275 patients Participants underwent p.R4810K sequencing. Serum antibody titers herpes...
INTRODUCTION: In patients with unruptured intracranial aneurysms (UIAs) who have recently experienced an ischemic stroke, determining the optimal timing for clipping or coiling is critical. Currently, no studies specifically explored this issue. METHODS: This study based on registered CAIASA and includes treated UIAs between October 2015 December 2020 at Beijing Tiantan Hospital, China. Clinical outcomes included symptomatic perioperative stroke confirmed by radiology examinations...
Background and Purpose— The study goal was to evaluate cerebral perfusion in moyamoya patients with a novel staging system investigate the association between differences of status clinical outcomes treated revascularization. Methods— About 506 consecutive from 2009 2015 were enrolled. evaluated by system-the stage preinfarction period based on result computed tomography perfusion. Hemisphere different compared hemorrhagic (n=155) ischemic (n=351). modified Rankin Scale applied prognosis...
Objective: To estimate the association between p. R4810K variant and clinical outcomes of patients with moyamoya disease (MMD). Methods: The p.R4810K genetic was genotyped among 498 Chinese MMD conducted from June 1, 2012, to 31, 2017. Data obtained by retrospective chart review, follow-up information outcome were through visits telephone. Results: Among patients, 361 (72.5%) wild-type (G/G), 133 (26.7%) heterozygous (G/A), 4 (0.8%) homozygotes (A/A). Compared GG group, in G/A+A/A group...
Abstract Background The research on postoperative collateral formation for hemorrhagic moyamoya disease (MMD) evaluated by using digital subtraction angiography (DSA) is limited. Our study objective was to investigate the after indirect bypass MMD. Methods All consecutive inpatients with MMD who received at Beijing Tiantan Hospital, Capital Medical University from January 2010 through December 2018 were screened. site of hemorrhage classified as either anterior or posterior. Postoperative...
Objective: To identify associated risk factors for the angiographic outcomes after direct and combined bypass surgery in moyamoya disease (MMD). Methods: All procedures performed from June 2009 to May 2015 were screened this prospective cohort study. Patients acquired presurgical follow-up catheter angiography included. Bypass patency postoperative collateral formation evaluated. Univariate multivariate logistic regression analyses determine influence formation. Results: In total, 188...
Background Internal carotid artery occlusion (ICAO) is a relatively uncommon but important cause of transient ischemic attack and cerebral infarction. The majority cases symptomatic ICAO requires surgical treatment. In this study we performed an investigation the efficacy safety hybrid surgery which method for chronic complete ICAO. Methods Fifty-five patients with treated by from 2016 to 2019 were included. We recorded analyzed patients' clinical characteristics, angiographic data,...
The risk factors of poor postoperative angiogenesis in moyamoya disease (MMD) patients remain unknown. We aimed to investigate the association between hyperhomocysteinemia (HHcy) and adult with MMD.A total 138 MMD were prospectively recruited from July 1 December 31, 2019. After excluding 10 accepting conservative therapy 77 individuals without digital subtraction angiography (DSA), all 51 enrolled, 28 received bilateral operations separately. Patients grouped according HHcy presentation,...
Abstract Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of internal carotid arteries formation compensatory collateral vessels. The etiology MMD remains enigmatic, making diagnosis management challenging. MOYAOMICS project was initiated to investigate molecular underpinnings explore potential diagnostic therapeutic strategies. Methods employs multidisciplinary approach, integrating various omics technologies,...