A5037467341- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Cancer-related gene regulation
- RNA modifications and cancer
- Galectins and Cancer Biology
- Wnt/β-catenin signaling in development and cancer
- Mesenchymal stem cell research
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- 3D Printing in Biomedical Research
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- Ion Transport and Channel Regulation
- Cancer Risks and Factors
- Congenital Diaphragmatic Hernia Studies
- Phytoestrogen effects and research
- Gynecological conditions and treatments
- Gastroesophageal reflux and treatments
Wenzhou Medical University
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
National Yang Ming Chiao Tung University
2014
Abstract Diabetic wound healing is a serious, complex, and chronic process; one current promising focusing technology in this area stem cell treatment. Here, novel porous microneedle (MN) arrays fabricated, which can highly mimetic niches, through template filling, particle etching method. The human adipose‐derived cells (ADSCs) are encapsulated Matrigel then loaded into the MN by post‐perfusion. Because of extracellular matrix‐mimicking, biocompatible offers bionic microenvironment nest...
In this letter, a gate recessed normally OFF AlGaN/GaN MIS-HEMT with low threshold voltage hysteresis using Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /AlN stack insulator is presented. The trapping effect of /GaN interface was effectively reduced the insertion 2-nm AlN thin interfacial passivation layer grown by plasma enhanced atomic deposition. device exhibits +1.5 V,...
Ferroptosis exhibits a potent antitumor effect and dihydroorotate dehydrogenase (DHODH) has recently been identified as novel ferroptosis defender. However, the role of DHODH inhibition in cervical cancer cells is unclear, particularly synergy with cisplatin via ferroptosis. Herein, shRNA brequinar were used to knock down directly inhibit DHODH, respectively. Immunohistochemistry Western blotting assays performed measure expression proteins. CCK-8 colony formation employed assess cell...
Cervical cancer is the most common gynecologic malignancy worldwide. Methyltransferase-like 3 (METTL3) involved in tumorigenesis; however, it unclear whether METTL3 plays a potential role regulating cisplatin (DDP) resistance. Therefore, of regulation sensitivity cervical cells was determined. Our immunohistochemistry (IHC) data showed that highly expressed para-cancerous compared with tissues. Furthermore, overexpression inhibited viability and increased vitro. Overexpression tumor growth...
The underlying mechanisms of methionine adenosyltransferase 2 A (MAT2A)-mediated cervical cancer progression under nutrient stress are largely elusive. Therefore, our study aims to investigate molecular mechanism by which MAT2A-indcued oncogenesis. interaction between MAT2A and programmed cell death protein 6 (PDCD6) in lines was detected immunoprecipitation, immunoblotting mass spectrometric analysis. panel inhibitors that linked responsive kinases were utilized detect related pathways...
Background: We previously revealed that the expression of galectin-1 (LGALS1) was significantly reduced after neoadjuvant chemotherapy treatment in cervical cancer patients. The objective this study is to investigate effects LGALS1 on biological behaviors cells. Methods: Immunohistochemistry and immunocytochemistry were performed detect tissues cells (SiHa C33A). Western blot analysis evaluate efficacy lentivirus-mediated upregulation or downregulation Cell viability proliferation detected...
Abstract Nanoparticles (NPs)‐based drug carriers are effective in reducing systemic toxicity and resistance for chemotherapy, an emerging trend focuses on integrating cell membranes with nanomedicines tumor targeting. Mesenchymal stem cells (MSCs) promising candidates due to their unique tropism toward cancer cells, yet the tumor‐tropic abilities can differ MSCs sourced from different tissues. Here, a multichannel microfluidic chip screen greatest cervical is developed. Based this, chorionic...
The receptor for advanced glycation endproducts (RAGE) expression has been reported to be implicated with cancer development. In this study, the role of RAGE in regulation cervical squamous cell proliferation, apoptosis and mechanism involved biological behaviors were explored.The was overexpressed or downregulated by lentivirus transfection. effect on proliferation explored CCK-8, MTT, BrdU assay, tumor development confirmed xenograft mouse model along immunohistochemistry stain...
Ovarian cancer is one of the most lethal gynecologic tumors in women and has a poor prognosis. The purpose our study was to identify new prognostic markers ovarian cancer. We examined roles mRNA expression chromobox (CBX) family patients with utilizing Kaplan-Meier plotter database. values levels CBX members associated prognosis were further evaluated using KM diverse subgroups immunohistochemistry (IHC) analysis carcinoma. results revealed that elevated CBX1-3 may predict overall survival...
Introduction Uterine fibroids are the most common pelvic benign tumour with no satisfactory long-term medical treatment. Recent studies have demonstrated that vitamin D significantly inhibited growth of in vitro, vivo and a small-sample clinical trial. Therefore, aim this randomised trial (RCT) is to evaluate whether supplementation could reduce risk inhibit uterine reproductive stage women. Methods analysis The open-label, RCT comprises two parts, including parts I II. In part I, 2230...
To investigate the effect of sevoflurane on progression cervical cancer cells, and to explore its cisplatinum (DDP) sensitivity in cells underlying mechanism.Siha Hela were cultured treated with 3% sevoflurane, 10 μmol/L DDP, or co-treatment respectively. Cell proliferation was evaluated by CCK8 assay. apoptosis assessed flow cytometry. migration detected wound healing The expression B-cell lymphoma-2 (BCL-2), associated X (BAX), Ezrin, matrix metalloproteinase 2 (MMP2), lung...