A5102001356- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Drug Transport and Resistance Mechanisms
- Virus-based gene therapy research
- Heat shock proteins research
- Redox biology and oxidative stress
- Autophagy in Disease and Therapy
- Medical Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Pelvic and Acetabular Injuries
- Protein Tyrosine Phosphatases
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Mesenchymal stem cell research
- Connexins and lens biology
- Neonatal Respiratory Health Research
- Cancer therapeutics and mechanisms
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- RNA modifications and cancer
Wenzhou Central Hospital
2024
Wenzhou Medical University
2019-2023
Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with expression level before chemotherapy.However, effect of PRDX6 on biological behavior is still uncertain.Thus, purpose this to explore functional impacts gene cells.Methods: An immunofluorescence assay applied evaluate difference between tissue and normal samples.A lentivirus used upregulate downregulate SiHa...
Background: We previously revealed that the expression of galectin-1 (LGALS1) was significantly reduced after neoadjuvant chemotherapy treatment in cervical cancer patients. The objective this study is to investigate effects LGALS1 on biological behaviors cells. Methods: Immunohistochemistry and immunocytochemistry were performed detect tissues cells (SiHa C33A). Western blot analysis evaluate efficacy lentivirus-mediated upregulation or downregulation Cell viability proliferation detected...
Cisplatin-based neoadjuvant chemotherapy and concurrent radiotherapy are the main treatment for advanced cervical cancer. However, development of multidrug resistance (MDR) leads to failure, tumor recurrence poor survival. In this research, we investigated effect corresponding mechanism leonurine on cisplatin sensitivity cancer cells.Anti-cervical efficacy combined with was examined in C33A Ms751 cells. The cell counting kit-8 assay bromodeoxyuridine were applied measuring proliferation....
Role of aquaporin-8 (AQP8) in cervical cancer has not been fully elucidated.We aim to explore the impacts AQP8 on viability, apoptosis and metastasis cells.AQP8 protein expression carcinoma specimens cell lines was detected by IHC western blot analysis. Lentivirus-mediated transfection used upregulate knockdown cells. Cell viability were assessed CCK-8 flow cytometry assays, respectively. Transwell experiments conducted investigate invasive migratory capabilities. EMT-related markers...
Oxidative stress serves a crucial role in tumor development. However, the relationship between ovarian cancer and oxidative remains unknown. We aimed to create an stress-related prognostic signature enhance prognosis prediction of CC patients using bioinformatics.
<h3>Background</h3> Detection of structural lesions the sacroiliac joint (SIJ) in patients with chronic low back pain is crucial for diagnosis and classification axial spondyloarthritis (axSpA). With MRI becoming a part routine diagnostic approach axSpA, question about value T1-weighted images (T1WI) evaluating raised. <h3>Objectives</h3> To construct validate radiomics model based on T1WI to assess SIJ suspected axSpA. <h3>Methods</h3> A total 266 clinical suspicion axSpA between December...