A5101779228- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Asthma and respiratory diseases
- Urinary and Genital Oncology Studies
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- Genomics, phytochemicals, and oxidative stress
- Esophageal Cancer Research and Treatment
- Spine and Intervertebral Disc Pathology
- Hypothalamic control of reproductive hormones
- Underwater Vehicles and Communication Systems
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Drug Transport and Resistance Mechanisms
- Health Literacy and Information Accessibility
- Bone Tumor Diagnosis and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Water Quality Monitoring Technologies
- Prostate Cancer Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Animal Nutrition and Physiology
- Genetic factors in colorectal cancer
Yueyang Hospital
2019-2024
Shanghai University of Traditional Chinese Medicine
2019-2024
University of Science and Technology of China
2023
Wenzhou Medical University
2020-2023
Xiamen University
2023
First Affiliated Hospital of Xiamen University
2023
Qiannan Normal College For Nationalities
2023
Capital Medical University
2018-2019
National Synchrotron Radiation Laboratory
2019
Capital University
2019
This study aimed to investigate the effects of quercetin on efficacy various chemotherapeutic drugs in cervical cancer cells.All drug experiments were performed HeLa and SiHa cells. The cell viability was detected by Cell Counting Kit-8 assay, proliferation estimated bromodeoxyuridine assay. CompuSyn software utilized calculate combination index (CI) evaluate synergistic or antagonistic effect with cisplatin, paclitaxel, 5-fluorouracil doxorubicin viability. migration invasion abilities...
The assessment of the muscle invasion bladder cancer typically plays a crucial role in therapeutic decision-making and has significant impacts on recurrence rate survival rate. Although histopathology is sufficiently accurate usually served as gold standard for diagnosis, it invasive, time-consuming, requires intensive sample preparation by well-trained pathologist to achieve an optimal diagnosis. Therefore, fast noninvasive method accurately identify non-muscle-invasive (NMIBC)...
With its well-documented toxicity, the use of doxorubicin (Dox) for cancer treatment requires trade-offs between safety and effectiveness. This limited Dox also hinders functionality as an immunogenic cell death inducer, thus impeding usefulness immunotherapeutic applications. Here, we develop a biomimetic pseudonucleus nanoparticle (BPN-KP) by enclosing GC-rich DNA within erythrocyte membrane modified with peptide to selectively target healthy tissue. By localizing organs susceptible...
Yimucao has been used as an herbal medicine to treat gynecological diseases. Common genes of active compounds were investigated using network pharmacology. The components and targets retrieved from the TCMSP database. Cervical cancer collected GeneCards, TTD, DisGeNET, KEGG. Cisplatin-related downloaded GeneWeaver. protein-protein interaction (PPI) was created STRING A drug-bioactive compound-disease-target constructed Cytoscape. GO KEGG analyses performed investigate common quercetin...
Objective Oblique lumbar interbody fusion (OLIF) and transforaminal (TLIF) are widely used in the treatment of degenerative diseases. A meta-analysis was performed to examine clinical radiological effects these two techniques. Methods search relevant literature from several databases conducted until November 2021. Perioperative outcomes, results, complications were analyzed. Results Fifteen qualified studies included. OLIF showed a shorter operative time length hospital stay less blood loss...
Cisplatin-based neoadjuvant chemotherapy and concurrent radiotherapy are the main treatment for advanced cervical cancer. However, development of multidrug resistance (MDR) leads to failure, tumor recurrence poor survival. In this research, we investigated effect corresponding mechanism leonurine on cisplatin sensitivity cancer cells.Anti-cervical efficacy combined with was examined in C33A Ms751 cells. The cell counting kit-8 assay bromodeoxyuridine were applied measuring proliferation....
Pancreatic cancer is a fatal malignancy with poor prognosis. The interactions between tumor cells and stromal contribute to progression. stellate (PSCs) play key role in tumor-stroma crosstalk of pancreatic cancer. in-depth exploration for helpful develop novel therapeutic strategies. Our aim was identify the potential core genes pathways crosstalk.3 microarray datasets were from Gene Expression Omnibus (GEO). Differentially expressed (DEGs) screened through bioinformatics analysis. Ontology...
Nucleus pulposus cell (NPC) senescence is a major cause of intervertebral disc degeneration (IVDD). Oxidative stress and reactive oxygen species (ROS) play critical roles in regulating senescence. Selenophosphate synthetase 1 (SEPHS1) was reported to an important role mitigating oxidative osteoarthritis (OA) model by reducing the production ROS, thereby, delaying occurrence development osteoarthritis. In this study, we explored the, hitherto unknown, SEPHS1 IVDD vitro vivo using...
Background. The current asthma guidelines encourage use of a diary for assessing and monitoring symptoms airway function. However, patient compliance acceptability are usually poor owing to the burden frequent prolonged assessment. Objective. We investigated whether better could be ensured if study was more relevant convenience had less impact on their daily life. Methods. A total 106 patients with symptomatic underwent fixed-time thrice-daily assessment schedule period lasting 2 weeks, they...
To evaluate the effects of quercetin on proliferation, invasion and migration endometrial stromal cells (ESCs) from adenomyosis patients.Primary ectopic ESCs (EESCs) eutopic (EuESCs) were obtained purified patients undergoing total hysterectomy for identified by immunocytochemistry staining. The cytotoxicity inhibition rate determined CCK-8 assay to obtain IC50 value. Cell proliferative, migratory, invasive abilities detected BrdU, wound scratch, transwell assays, respectively. Western blot...
Background: Atopic eczema is the most common type of skin disorder in both children and adults. It characterized by erythema, pruritus, papules, xeransis, lichenification. Qinzhuliangxue decoction (QZLXD), a Chinese herbal medicine (CHM) prepared with several ingredients that are used to treat eczema, was formulated according traditional (TCM) theory. This study aimed investigate efficacy safety QZLXD administration for treating atopic compared those Runzaozhiyang capsules (RZZYC). Methods:...
Abstract Background Changshun green-shell laying hens are unique to the Guizhou Province, China, and have high egg quality but relatively low yield. Egg production traits regulated by hypothalamus-pituitary-ovary axis. However, underlying mechanism remains unclear. Thus, we conducted RNA sequencing of hypothalamic pituitary tissues from low- high-yielding identify critical pathways candidate genes involved in controlling rate. Results More than 39 million clean reads per sample were...
Muscle-invasive bladder cancers (MIBCs) are heterogeneous and can be grouped into basal-like luminal subtypes that highly reminiscent of those found in breast cancer. Like cancers, MIBCs associated with advanced stage metastatic disease. However, the biological clinical significance molecular remain unclear. Therefore, we implemented a serious bioinformatics methods to explore genetic similarities between cancers.
Abstract Background Bladder cancer is a complex disease associated with high morbidity and mortality. Management of bladder before radical cystectomy continues to be controversial. We compared the long-term efficacy one-shot neoadjuvant intra-arterial chemotherapy (IAC) versus no IAC (NIAC) (RC) for cancer. Methods performed retrospective review patients who underwent either or NIAC RC between October 2006 November 2015. A propensity-score matching (1:3) was based on key characters. The...
Background Intervertebral disc degeneration (IDD) is a progressive chronic condition that commonly causes low back pain. Cancer among the primary reasons for deaths worldwide. Our purpose was to identify characteristic genes of IDD and explore potential association between cancer. Methods Immune cell infiltration differentially expressed analysis were conducted utilizing data from GSE124272 database. Enrichment (DEGs) performed possible mechanisms underlying development. Moreover, weighted...
Background: Bone giant cell tumor (BGCT) is one of the world's major disease types locally aggressive bone tumors. In recent years, denosumab treatment has been introduced before curettage surgery. However, current therapeutic was practical only sometimes, given local recurrence effects after discontinuation denosumab. Due to complex nature BGCT, this study aims use bioinformatics identify potential genes and drugs associated with BGCT. Methods: The that integrate BGCT fracture healing were...
Abstract Background: Bladder cancer is a complex disease associated with high morbidity and mortality. Management of bladder before radical cystectomy continues to be controversial. We compared the long-term efficacy one-shot neoadjuvant intra-arterial chemotherapy (IAC)versus no IAC (NIAC) (RC) for cancer. Methods: performed retrospective review patients who underwent either or NIAC RC between October 2006 November 2015. A propensity-score matching (1:3) was based on key characters. The...
Abstract Background: Bladder cancer is a complex disease associated with high morbidity and mortality. The management of bladder before radical cystectomy continues to be controversial. We compared the long-term efficacy one-shot neoadjuvant intra-arterial chemotherapy (IAC)versus no IAC (NIAC) (RC) for cancer. Methods: performed retrospective review patients who underwent either or NIAC RC between October 2006 November 2015. Propensity-score matching (1:3) was based on key characteristics....
Abstract Background: Bladder cancer is a complex disease associated with high morbidity and mortality. The management of bladder before radical cystectomy continues to be controversial. We compared the long-term efficacy one-shot neoadjuvant intra-arterial chemotherapy (IAC)versus no IAC (NIAC) (RC) for cancer. Methods: performed retrospective review patients who underwent either or NIAC RC between October 2006 November 2015. Propensity-score matching (1:3) was based on key characteristics....
Abstract Background: Bladder cancer is a complex disease associated with high morbidity and mortality. Management of bladder before radical cystectomy continues to be controversial. We compared the long-term efficacy one-shot neoadjuvant intra-arterial chemotherapy (IAC) versus no IAC (NIAC) (RC) for cancer. Methods: performed retrospective review patients who underwent either or NIAC RC between October 2006 November 2015. A propensity-score matching (1:3) was based on key characters. The...