A5008144684- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Chemical Synthesis and Analysis
- Photosynthetic Processes and Mechanisms
- Trace Elements in Health
- Biopolymer Synthesis and Applications
- Crop Yield and Soil Fertility
- DNA and Biological Computing
- Peptidase Inhibition and Analysis
- Legume Nitrogen Fixing Symbiosis
- Folate and B Vitamins Research
- Plant-Microbe Interactions and Immunity
- Pharmacological Receptor Mechanisms and Effects
- Adenosine and Purinergic Signaling
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Genetics and Plant Breeding
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Proteins in Food Systems
- Polyamine Metabolism and Applications
- Molecular Communication and Nanonetworks
- Peroxisome Proliferator-Activated Receptors
- Safety Warnings and Signage
University of Science and Technology of China
2008-2025
Hefei National Center for Physical Sciences at Nanoscale
2019-2024
Shenzhen Institutes of Advanced Technology
2024
Stanford University
2023-2024
Xinjiang University
2024
Kangmei Pharmaceutical (China)
2024
Nokia (Finland)
2024
China Tobacco
2024
New England Biolabs (United States)
2023
Suzhou Chien-Shiung Institute of Technology
2023
AlphaFold2 (AF2) models have had wide impact but mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 of the σ
Bilirubin is mainly generated from the breakdown of heme when red blood cells reach end their lifespan. Accumulation bilirubin in human body usually leads to various disorders, including jaundice and liver disease. conjugated hepatocytes excreted bile duct via ATP-binding cassette transporter ABCC2, dysfunction which would lead Dubin-Johnson syndrome. Here we determine structures ABCC2 apo, substrate-bound ATP/ADP-bound forms using cryo-electron microscopy, exhibiting a full with regulatory...
Selenium (Se) is an essential trace element in most organisms but has to be carefully handled since there a thin line between beneficial and toxic concentrations. Many bacteria have the ability reduce selenite (Se(IV)) (or) selenate (Se(VI)) red elemental selenium that less toxic. A strictly aerobic bacterium, Comamonas testosteroni S44, previously isolated from metal(loid)-contaminated soil southern China, reduced Se(IV) nanoparticles (SeNPs) with sizes ranging 100 200 nm. Both energy...
The reverse cholesterol transport pathway is responsible for the maintenance of human homeostasis, an imbalance which usually leads to atherosclerosis. As a key component this pathway, ATP-binding cassette transporter ABCG1 forwards cellular extracellular acceptor nascent high-density lipoprotein (HDL). Here, we report 3.26-Å cryo-electron microscopy structure cholesterol-bound in inward-facing conformation, represents turnover condition upon ATP binding. Structural analyses combined with...
Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to peroxisome for β-oxidation, dysfunction of which usually causes the X-linked adrenoleukodystrophy (X-ALD). Here, we report three cryogenic electron microscopy structures ABCD1: apo-form, substrate- and ATP-bound forms. Distinct what was seen in previously reported transporters, two symmetric molecules behenoyl coenzyme A (C22:0-CoA) cooperatively bind transmembrane domains (TMDs). For each C22:0-CoA,...
Abstract AlphaFold2 (AF2) and RosettaFold have greatly expanded the number of structures available for structure-based ligand discovery, even though retrospective studies cast doubt on their direct usefulness that goal. Here, we tested unrefined AF2 models prospectively , comparing experimental hit-rates affinities from large library docking against vs same screens targeting receptors. In σ 2 5-HT2A receptors, struggled to recapitulate ligands had previously found receptors’ structures,...
Abstract The human ABC transporter ABCC3 (also known as MRP3) transports a wide spectrum of substrates, including endogenous metabolites and exogenous drugs. Accordingly, it participates in multiple physiological processes is involved diverse diseases such intrahepatic cholestasis pregnancy, which caused by the intracellular accumulation bile acids estrogens. Here, we report three cryogenic electron microscopy structures ABCC3: apo‐form complexed forms bound to either conjugated sex hormones...
Aurantimycin (ATM), produced by Streptomyces aurantiacus JA 4570, is a potent antimicrobial and antitumor antibiotic. Although the chemical structure of ATM highly distinctive features cyclohexadepsipeptide scaffold attached with C14 acyl side chain, little known about its biosynthetic pathway regulatory mechanism.In this work, we report identification characterization gene cluster from S. 4570. Targeted inactivation artG, coding for NRPS enzyme, completely abolished production, thereof...
Genetic dissection kernel weight-related traits is of great significance for improving wheat yield potential. As one the three major components wheat, thousand weight (TKW) was mainly affected by grain length (GL) and width (GW). To uncover key loci these traits, we carried out a quantitative trait (QTL) analysis an F6 recombinant inbred lines (RILs) population derived from cross Henong 5290 (small grain) 06Dn23 (big with 50 K single nucleotide polymorphism (SNP) array. A total 17 stable big...
Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH 3 , and OCH ), were developed with strong red fluorescence large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells zebrafish.
Strain GZ436(T) was Gram-stain-negative, aerobic, non-motile, rod-shaped and isolated from the soil of a coal mine. 16S rRNA gene phylogenetic analysis showed that this strain clustered with Thermomonas brevis LMG 21746(T) (97.5%), haemolytica A50-7-3(T) (96.3%), koreensis KCTC 12540(T) (96.4%), hydrothermalis SGM-6(T) (95.5%) fusca 21737(T) (95.1%). The major isoprenoid quinone Q-8. DNA G+C content 67 mol%. contained phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine, an...