A5101969534- Advanced Drug Delivery Systems
- Wastewater Treatment and Nitrogen Removal
- 3D Printing in Biomedical Research
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Glaucoma and retinal disorders
- Anaerobic Digestion and Biogas Production
- Constructed Wetlands for Wastewater Treatment
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- Microbial Community Ecology and Physiology
- Additive Manufacturing and 3D Printing Technologies
- Microbial Fuel Cells and Bioremediation
- Vestibular and auditory disorders
- Archaeology and ancient environmental studies
- Neonatal and fetal brain pathology
- Lipid Membrane Structure and Behavior
- Metal-Organic Frameworks: Synthesis and Applications
- Protein purification and stability
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Phytochemical compounds biological activities
- Membrane Separation Technologies
Henan Provincial People's Hospital
2025
Hubei University
2024
Yunnan Archaeology
2020-2024
Beijing University of Technology
2023-2024
Beijing University of Posts and Telecommunications
2024
Purple Mountain Laboratories
2024
Guangdong Pharmaceutical University
2014-2023
Chongqing University
2021-2023
Central South University
2023
Shanghai Jiao Tong University
2023
The zeolitic imidazolate framework (ZIF-8), composed of zinc ion and dimethylimidazole, is widely used in drug delivery because the easy fabrication process good biosafety. However, ZIF-8 suffers from low affinity to nonelectric-rich drugs does not have surface functional groups. Here, deliver doxorubicin (DOX) with specific target sites, DOX was first modified a pH-sensitive linker containing two carboxyl groups form inactive prodrug CAD subsequently seeded inside by 5 min mineralization...
A pH/redox-triggered mesoporous silica nanoparticle (MSN)-based nanoplatform has been fabricated for doxorubicin/paclitaxel (DOX/PTX) codelivery. In this drug-delivery system (DDS), PTX is covalently attached to the surface of DOX loaded MSN via a linker with disulfide bond. By directly attaching MSN, we can significantly enhance PTX́s loading degree and achieve optimum drug ratio DOX, therefore, generate best synergistical effect. More importantly, act as redox-sensitive "gate" precisely...
There are few systematic studies using microneedles to deliver ibuprofen through the skin. In this study, Ibuprofen was encapsulated in poly (lactide-co-Glycolide) (PLGA) network form nanoparticles(IBU-NPs), then IBU-NPs were mixed with Sodium Hyaluronate fabricate dissolving array patch (MNP) and applied mice model observe its effect. mouse model, could effectively significantly reduced number of writhe, mRNA CGRP, COX-2, TNF–α, IL-1β, IL-6 increased opioid receptor. This study introduces a...
Individualized medicine is a new direction in the field of modern pharmacy. In this study, we assessed feasibility and accuracy 3D printing techniques for preparation individualized doses mouth-disintegrating tablets warfarin. Warfarin sodium, D-sucrose, pregelatinized starch, povidone K30, microcrystalline cellulose, silicon dioxide (at ratio 1:42.45:46.15:5.1:4.9:0.4) were mixed used as powder printer; preset parameters used. The dosage tablet was controlled by number layers. content, dose...
Delivery of biomacromolecular drugs into the inner ear is challenging, mainly because their inherent instability as well physiological and anatomical barriers. Therefore, protein-friendly, hydrogel-based delivery systems following local administration are being developed for therapy. Herein, biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) containing interferon α-2 b (IFN b) were loaded in chitosan/glycerophosphate (CS/GP)-based thermosensitive hydrogel IFN by...
This study aims to evaluate the clinical utility of metagenomic next-generation sequencing (mNGS) for diagnosing central nervous system infections (CNSIs) during perioperative period in neurosurgical intensive care unit (ICU) patients. In this prospective study, we included patients suspected CNSIs who were admitted Neurosurgical-ICU at Henan Provincial People's Hospital. Clinical samples tested using both mNGS and conventional pathogen culture methods. Based on comprehensive diagnoses,...
Abstract Starting from D,L ‐acid and SnCl 2 as catalyst, poly( ‐lactic acid) (PDLLA) was directly synthesized by melt polycondensation. Under the appropriate conditions such 0.5 wt % , 170–180°C, 70 Pa, 10 h, viscosity‐average molecular weight ( M η ) of PDLLA 4100 Da. produced most practical method used drug‐delivery material for erythromycin ciprofloxacin. The optimal preparation erythromycin–poly( acid)–microsphere (ERY–PDLLA–MS) lung targeting investigated, further confirmed good...
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order improve efficacy. We previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the anti-glaucoma betaxolol hydrochloride (BHC) exhibited sustained release thus intraocular pressure (IOP) lowering effects. Here, we investigated effect of physicochemical particle parameters on micro-interactions tear film mucins corneal epithelial cells....
The aim of this study was to determine the effect varying excipient content on formation and physical properties 3 D printed tablets. Fifteen different preparations were formed into tablets with radii 5 mm thickness 2 mm, using binder jetting (BJ). analyzed by assessing visual microstructural appearance, friability, hardness, disintegration time. We found that filling agents high water solubility (e.g. D-sucrose), binding a viscosity in solution polyethylene glycol 4000) moistening agent...
Glaucoma is a serious eye disease that can lead to loss of vision. Unfortunately, effective treatments are limited by poor bioavailability antiglaucoma medicine due short residence time on the preocular surface.To solve this, we successfully prepared novel controlled-release ion-exchange microparticles deliver betaxolol hydrochloride (BH). Montmorillonite/BH complex (Mt-BH) was acidification-intercalation, and this encapsulated in microspheres (Mt-BH [BMEMs]) oil-in-oil emulsion-solvent...