A5065882679- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Cancer Treatment and Pharmacology
- Advanced Drug Delivery Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- 3D Printing in Biomedical Research
Guangdong Pharmaceutical University
2020-2021
Guangdong Testing Institute for Product Quality Supervision
2020
The aim of this work was to develop a novel and feasible modification strategy by utilizing the supramolecular effect 2-hydroxypropyl-beta-cyclodextrin (2-HP-β-CD) for enhancing biological transport efficiency paclitaxel (PTX)-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles.PTX-loaded 2-HP-β-CD-modified PLGA nanoparticles (2-HP-β-CD/PLGA NPs) were prepared using modified emulsion method. Nano-characteristics, drug release behavior, in vitro cytotoxicity, cellular uptake profiles vivo...
Abstract Background: The aim of this work was to develop a novel and feasible modification strategy by utilizing the supramolecular effect 2-hydroxypropyl-beta-cyclodexrin (2-HP-β-CD) for enhancing biological transport efficiency paclitaxel (PTX)-loaded poly(lactide-co-glycolide)(PLGA) nanoparticles. Methods: PTX-loaded 2-HP-β-CD-modified PLGA nanoparticles (2-HP-β-CD/PLGA NPs) were prepared using modified emulsion method. Nano-characteristics, drug release behavior, in vitro cytotoxicity,...