A5007721677- Biomedical Text Mining and Ontologies
- Fungal Plant Pathogen Control
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Metabolomics and Mass Spectrometry Studies
- Complementary and Alternative Medicine Studies
- Bioinformatics and Genomic Networks
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Studies
- Machine Learning in Healthcare
- COVID-19 Clinical Research Studies
Nankai University
2023-2024
Beijing Jiaotong University
2020-2023
Chinese medicine (CM) was extensively used to treat COVID-19 in China. We aimed evaluate the real-world effectiveness of add-on semi-individualized CM during outbreak. A retrospective cohort 1788 adult confirmed patients were recruited from 2235 consecutive linked records retrieved five hospitals Wuhan 15 January 13 March 2020. The mortality users and non-users compared by inverse probability weighted hazard ratio (HR) propensity score matching. Change biomarkers between groups, frequency...
Abstract Clinical symptom‐based diagnosis and therapy play a crucial role in personalized medicine drug discovery. The syndromes, distinctive groups of clinical symptoms summarized by traditional Chinese (TCM) theories experiences, are used as the core diagnostic criteria therapeutic guidance TCM. However, there is still lack standardized data, information, intrinsic molecular basis to help TCM syndromes better classify diseases guide tailored medications. To address this problem, we built...
Target based molecular design via the aid of computation is one most efficient methods in discovery novel pesticides. Here, a combination comparative field analysis (CoMFA) and docking was applied for potent fungicidal [1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazoles. Bioassay results indicated that synthesized target compounds 3a, 3b, 3c exhibited good activity against Alternaria solani, Botrytis cinerea, Cercospora arachidicola, Fusarium graminearum, Physalospora piricola, Rhizoctonia...
To discover novel inhibitors of the complex I reduced nicotinamide adenine dinucleotide (NADH) oxidoreductase as fungicides, a series 6-isothiazol-5-ylpyrimidin-4-amine-containing compounds were designed using computer-aided pesticide design method and splicing substructures from diflumetorim isotianil. In vitro fungicidal bioassays indicated that
Background: Previous studies showed that the effect of antivirals for COVID-19 was promising but varied across patient population, and modest among severe cases. Chinese Medicine (CM) extensively used reported effective in China, awaiting further evidence support. We aimed to evaluate real-world effectiveness add-on semi-individualized.Methods: A retrospective total sampling cohort 1788 adult confirmed patients were recruited from all 2235 consecutive records retrieved 5 hospitals Wuhan...