A5102758711- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Promotion and Cardiovascular Prevention
- Diabetes Management and Research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Chronic Disease Management Strategies
- Cardiovascular Health and Risk Factors
- Congenital Heart Disease Studies
- Lipoproteins and Cardiovascular Health
- Healthcare Systems and Public Health
- Infective Endocarditis Diagnosis and Management
- Machine Learning in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Cardiovascular Effects of Exercise
- Cancer, Lipids, and Metabolism
- Healthcare cost, quality, practices
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2009-2024
State Key Laboratory of Cardiovascular Disease
2018-2024
Fu Wai Hospital
2012-2024
Brigham and Women's Hospital
2014-2019
Thrombolysis in Myocardial Infarction Study Group
2014-2019
Harvard University
2016
Acute myocardial infarction (AMI) has become a major cause of hospitalization and mortality in China. There been limited data to date available characterize AMI presentation, contemporary patterns medical care, outcomes China.The CAMI Registry is national project with the objectives timely obtain real-world knowledge about patients provide platform for clinical research, guide preventive measures care quality improvement efforts registry prospective, nationwide, multicenter observational...
Background We studied the concomitant use of single antiplatelet therapy ( SAPT ) on efficacy and safety anti‐Xa agent edoxaban in patients with atrial fibrillation AF ). Methods Results ENGAGE ‐ TIMI 48 was a randomized trial that compared 2 dose regimens warfarin. both approved higher‐dose regimen HDER ; 60 mg daily reduced by one half anticipated increased drug exposure), as well lower‐dose LDER 30 daily, also regimen). (aspirin 92.5%) administered at discretion treating physician. Cox...
The epidemiology and management of valvular heart disease (VHD) have changed with economic development population aging in China recent decades.This study sought to understand the distribution, etiology, presentation assess current practice outcomes older patients VHD China.The authors conducted first nationwide survey between September December 2016 from 69 hospitals 28 provinces municipalities throughout China. Hospitalized over 60 years age moderate-to-severe VHD, infective endocarditis,...
Abstract Background Stress hyperglycemia was positively associated with poor prognosis in individuals acute myocardial infarction (AMI). However, admission glucose and stress ratio (SHR) may not be the best indicator of hyperglycemia. We performed this study to evaluate comparative prognostic value different measures (fasting SHR, fasting plasma [FPG], hemoglobin A1c [HbA1c]) for in-hospital mortality AMI patients or without diabetes. Methods In prospective, nationwide, multicenter China...
<h3>Importance</h3> The incidence of acute myocardial infarction has increased over the past decades in China, and management challenges include an unbalanced economy, disparate resources, variable access to medical care across nation. <h3>Objective</h3> To examine variations outcomes patients with ST-segment elevation among 3 levels hospitals typical Chinese public hospital model. <h3>Design, Setting, Participants</h3> This cross-sectional study used data from China Acute Myocardial...
Abstract Aims To assess the predictive value of stress hyperglycemia ratio (SHR) for long‐term mortality after acute myocardial infarction (AMI) in patients with and without diabetes. Materials Methods We evaluated 6892 AMI from prospective, nationwide, multicentre China Acute Myocardial Infarction registry, which 2820 had diabetes, remaining 4072 were nondiabetic patients. Patients divided into high SHR low groups according to optimal cutoff values predict diabetic patients, respectively....
Abstract Background Recent publications reported a paradoxical finding that there was an inverse association between the number of standard modifiable risk factors (SMuRFs; smoking, hypertension, diabetes, and hyperlipidemia) mortality in patients with myocardial infarction. However, current evidence is only limited to those highly developed countries advanced medical management systems. Methods The China Acute Myocardial Infarction registry prospective observational study including acute...
Abstract Background and Aims Physical activity has proven effective in preventing atherosclerotic cardiovascular disease, but its role degenerative valvular heart disease (VHD) remains uncertain. This study aimed to explore the dose–response association between moderate vigorous physical (MVPA) volume risk of VHD among middle-aged adults. Methods A full week accelerometer-derived MVPA data from 87 248 UK Biobank participants (median age 63.3, female: 56.9%) 2013 2015 were used for primary...
Abstract Aims The cardiovascular-kidney-metabolic (CKM) health approach emphasizes the importance of multidisciplinary early-stage disease prevention. This study aimed to explore sex differences in CKM risk factors associated with common degenerative valvular heart (VHD). Methods A total 436,184 participants (54.4% women; mean age, 58 years) free VHD or failure at baseline and complete information about were included from UK Biobank cohort. We assessed hazard ratios (HRs)...
To create a multiple and mixed valvular heart disease (MVHD)-related age-adjusted comorbidity index (MVACI) for predicting mortality risk of patients with MVHD. A total 4080 moderate or severe MVHD in the China-VHD study were included. The primary endpoint was 2-year all-cause mortality. MVACI prediction model constructed based on factors identified by univariate multivariate Cox regression analysis. Restricted cubic spline curves plotted to assess relationship between scores optimal...
Objective To explore the association of wearable device-measured moderate-to-vigorous intensity physical activity (MVPA) with cardiovascular disease (CVD) risk in long-term cancer survivors. Methods This retrospective analysis involved a prospective cohort 6109 survivors without CVD from UK Biobank accelerometry subsample. The MVPA volume is categorised into four groups based on guideline recommendations (0–75 min/week, 75–150 150–300 ≥300 min/week). Cox proportional hazard models are used...
Young people hold a stable or increasing percentage of patients with acute myocardial infarction (AMI) in many countries. However, data on clinical characteristics and outcomes young AMI were insufficient. This study aimed to analyze characteristics, prognosis, gender disparities aged ≤45 years AMI.
Background The prognostic effect of admission blood glucose (ABG) for patients with acute myocardial infarction (AMI) has not been well validated, especially in diabetes. We performed this study to assess the predictive value ABG all-cause mortality AMI different metabolism status. Methods evaluated a total 6,892 from prospective, nationwide, multicenter CAMI registry, which 2,820 had diabetes, 2,011 pre-diabetes, and 2,061 normal regulation (NGR). Patients were divided into high low groups...
The incidence, clinical outcomes and antithrombotic treatment spectrum of atrial fibrillation (AF) in patients hospitalized with acute myocardial infarction (AMI) have not been well studied Chinese population. Twenty-six thousand five hundred ninety-two consecutive diagnosed AMI were enrolled CAMI registry from January 2013 to September 2014. After excluding 343 uncertain AF status 1,591 transferred out during hospitalization, 24,658 finally included this study involved analysis. In the...
Background:Accurate risk stratification of non-ST segment elevation myocardial infarction (NSTEMI) patients is important due to great variability in mortality risk, but, date, no prediction model has been available. The aim this study was therefore establish a score predict in-hospital NSTEMI patients.
Approximately 70% patients with acute myocardial infarction (AMI) presented without ST-segment elevation on electrocardiogram. Patients non-ST segment (NSTEMI) often atypical symptoms, which may be related to pre-hospital delay and increased risk of mortality. However, up date few studies reported detailed symptomatology NSTEMI, particularly among Asian patients. The objective this study was describe compare symptoms presenting characteristics NSTEMI vs. STEMI
Abstract Background Data on fibrinolytic therapy use for ST-segment elevation myocardial infarction (STEMI) and long-term clinical outcomes in developing countries are limited. We aimed to investigate the management 2-year mortality of fibrinolytic-treated patients China. Methods A total 19,112 with STEMI from 108 hospitals participated China Acute Myocardial Infarction registry between January 2013 September 2014. investigated all-cause among treated fibrinolysis. Non-invasive indexes were...
Inflammation is associated with an increased risk of developing various cancers in both animals and humans, primarily solid tumors but also myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), acute myeloid leukemia (AML). Multi-walled carbon nanotubes (MWCNTs), a type (CNTs) increasingly used medical research other fields, are leading to rising human exposure. Our study demonstrated that exposing mice MWCNTs accelerated the progression spontaneous MOL4070LTR virus-induced...
Diabetes is frequently associated with poor prognosis among acute myocardial infarction (AMI) patients. Patients these comorbidities often have atypical symptoms and subsequent delay in treatment. Few studies reported detailed AMI patients diabetes. This study compared presentation characteristics between diabetics non-diabetics.We included from the China registry diagnosed January 2013 September 2014. Baseline characteristics, symptomology, treatment were non-diabetics. Multivariable...
Introduction Smoking is a well-established risk factor for cardiovascular disease. However, the effect of smoking on in-hospital mortality in patients with acute myocardial infarction (AMI) who are managed by contemporary treatment still unclear. Methods A cohort study was conducted using data from China AMI registry between 2013 and 2016. Eligible were diagnosed accordance third universal definition MI. Propensity score (PS) matching multivariable logistic regression used to control...