A5087363491- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Mitochondrial Function and Pathology
- Pharmacological Effects of Natural Compounds
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Apelin-related biomedical research
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Firm Innovation and Growth
- Complementary and Alternative Medicine Studies
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Xiangya Hospital Central South University
2017-2021
Central South University
2017-2021
Insulin resistance (IR) is the primary pathological mechanism underlying type 2 diabetes mellitus (T2DM). Here, study aimed to ascertain whether and how exercise mediates IR in T2DM. An vivo mouse model of high-fat diet-induced an vitro high-glucose-induced were constructed. High long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression was detected T2MD positively correlated with HOMA-IR resistin levels. Then, short hairpin targeting MALAT1...
Mounting evidence has firmly established that increased exercise capacity (EC) is associated with considerable improvements in the survival of patients cardiovascular disease (CVD) and antistress a prognostic predictor adverse events CVD. Previous studies have indicated aerobic (AE) supplementation Rhodiola sacra (RS), natural plant pharmaceutical, improve EC enable resistance to stress; however, underlying mechanism remains unclear. This study explored ability AE RS, alone or combined,...
To create a multiple and mixed valvular heart disease (MVHD)-related age-adjusted comorbidity index (MVACI) for predicting mortality risk of patients with MVHD. A total 4080 moderate or severe MVHD in the China-VHD study were included. The primary endpoint was 2-year all-cause mortality. MVACI prediction model constructed based on factors identified by univariate multivariate Cox regression analysis. Restricted cubic spline curves plotted to assess relationship between scores optimal...
To explore the effects of trimetazidine combined with exercise on EC and anti-fatal stress ability, illustrate underlying mechanism.C57BL/6 mice were randomly assigned to four groups (n = 11 in each group): control, exercise, + (TE) groups. Mice accordingly given saline (ig), Aerobic (AE), or a combination (ig) AE for five weeks. After intervention, group was subdivided into rest exhaustive (EE) subgroups. The control-EE TE-EE subgroups underwent fatal experiments. ability assessed...
Mitochondrial quality control (MQC) and function are determinants for cellular energy metabolism, their disorders reported to play an important role in the development of insulin resistance (IR). Salidroside was have beneficial effects on MQC through AMPK pathway; however, it is unknown whether salidroside exerts anti-IR effect with this action. This study sought investigate IR exploration mechanisms its Experimental models were adopted high-fat-diet (HFD)-fed mice palmitate-treated C2C12...
Background: Anti-stress capacity is important to resist the occurrence of adverse events. To observe effects exercise, trimetazidine alone or combined on anti-stress mice, and further explore its potential mechanism. Methods: Forty-four C57BL/6 male mice aged 8 weeks were randomly divided into four groups (n=11 for each group): control group (group C), exercise E), T), with TE). After intervention, was subdivided exhaustive (EE, n=6) non-EE (n=5) subgroups. The in EE-subgroup underwent EE....
Muscle dysfunction is a complication of high-fat diet (HFD)-induced obesity that could be prevented by exercise, but patients did not get enough therapeutic efficacy from exercise due to multiple reasons. To explore alternative or supplementary approaches prevent treat muscle in individuals with obesity, we investigated the effects Rhodiola on as pills. SIRT1 might suppress atrogenes expression and improve mitochondrial quality control, which target stimulated Rhodiola, further mechanisms...