A5100689136- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Kawasaki Disease and Coronary Complications
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Cardiac tumors and thrombi
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic and Hepatic Oncology Research
- Cardiac Health and Mental Health
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Medication Adherence and Compliance
- Aortic aneurysm repair treatments
- Cardiovascular Disease and Adiposity
- COVID-19 and healthcare impacts
- Cardiovascular Health and Risk Factors
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
State Key Laboratory of Cardiovascular Disease
2017-2024
Sun Yat-sen Memorial Hospital
2012-2024
Sun Yat-sen University
2012-2024
Central Hospital Affiliated to Shenyang Medical College
2024
National Clinical Research Center for Digestive Diseases
2020-2023
Fu Wai Hospital
2014-2023
National Clinical Research
2021-2023
Peking Union Medical College Hospital
2021-2022
First Hospital of Jiaxing
2021
Abstract Background Inflammation plays a crucial role in the pathogenesis and progression of coronary artery disease (CAD). The neutrophil to lymphocyte ratio (NLR) is novel inflammatory biomarker its association with clinical outcomes CAD patients different glycemic metabolism after percutaneous intervention (PCI) remains undetermined. Therefore, this study aimed investigate effect NLR on prognosis undergoing PCI or without type 2 diabetes mellitus (T2DM). Methods We consecutively enrolled...
Abstract Background Stress hyperglycemia was positively associated with poor prognosis in individuals acute myocardial infarction (AMI). However, admission glucose and stress ratio (SHR) may not be the best indicator of hyperglycemia. We performed this study to evaluate comparative prognostic value different measures (fasting SHR, fasting plasma [FPG], hemoglobin A1c [HbA1c]) for in-hospital mortality AMI patients or without diabetes. Methods In prospective, nationwide, multicenter China...
Abstract Background The triglyceride-glucose (TyG) index and the stress hyperglycaemia ratio (SHR) are both positively associated with cardiovascular (CV) risk in patients coronary heart disease. However, prognostic value of these two biomarkers has not been well elucidated chronic total occlusion (CTO). Therefore, this study aims to evaluate association TyG SHR long-term prognosis CTO. Methods This prospective cohort consecutively included 2740 angina CTO from January 2017 December 2018 at...
The aim of this study was to use optical coherence tomography (OCT) predict newly implanted stent expansion for treatment in-stent restenosis (ISR).With OCT guidance, 143 ISR lesions were treated with a new stent. Stent underexpansion defined as minimum area (MSA) <4.5 mm2 and MSA/average reference lumen <70%. New found in 33 (23%). These had smaller old MSA (4.13 [3.32-4.62] versus 5.18 [4.01-6.38] mm2, p=0.001), higher prevalence multiple layers (51.5% 10.9%, p<0.001) neointimal or...
Abstract Aims To assess the predictive value of stress hyperglycemia ratio (SHR) for long‐term mortality after acute myocardial infarction (AMI) in patients with and without diabetes. Materials Methods We evaluated 6892 AMI from prospective, nationwide, multicentre China Acute Myocardial Infarction registry, which 2820 had diabetes, remaining 4072 were nondiabetic patients. Patients divided into high SHR low groups according to optimal cutoff values predict diabetic patients, respectively....
In-stent restenosis (ISR) is an important cause of drug-eluting stent (DES) failure and target vessel revascularisation. In this study we aimed to evaluate differences between early late-presenting in second-generation DES using optical coherence tomography (OCT).Overall, 171 cases ISR with a follow-up OCT minimum lumen area <3.0 mm2 were included: 33.3% patients (n=57) had ISR, 66.7% (n=114) late (duration from implantation >1 year). Minimum (MSA) <4.0 mm2, neointimal thickness <100 µm,...
Abstract Functional complete revascularization (CR) after percutaneous coronary intervention (PCI) as determined by classic residual functional SYNTAX score (c‐rFSS) has been associated with improved prognosis. In this study, the c‐rFSS algorithm is optimized for a novel modified rFSS (m‐rFSS) and prognostic implications of scoring determined. The m‐rFSS updated 2 clinical scenarios, i.e., 1) lesions suboptimal results, 2) angiographic diameter stenosis <50% but functionally significant...
Complete blood count (CBC)-derived indices have been proposed as reliable inflammatory biomarkers to predict outcomes in the context of coronary artery disease. These yet be thoroughly validated patients with intermediate stenosis. Our study included 1527 only The examined variables were neutrophil-lymphocyte ratio (NLR), derived NLR, monocyte-lymphocyte (MLR), platelet-lymphocyte (PLR), systemic immune inflammation index (SII), system response (SIRI), and aggregate (AISI). primary endpoint...
Objectives We aimed to investigate the effect of bifurcation angle (BA) on side branch (SB) occlusion after main vessel (MV) stenting. Background : BA is thought impact risk SB in coronary patients undergoing percutaneous intervention (PCI). Methods A total 1,171 consecutive with 1,200 lesions one stent or provisional two techniques were studied. The divided into low and high groups using median (52°). Multivariate logistic regression analysis was performed identify independent predictors...
Background The PRAISE (Prediction of Adverse Events Following an Acute Coronary Syndrome) score is a machine-learning-based model for predicting 1-year all-cause death, myocardial infarction, and Bleeding Academic Research Consortium (BARC) type 3/5 bleeding. Its utility in unselected Asian population undergoing percutaneous coronary intervention acute syndrome remains unknown. We aimed to validate the real-world population. Methods Results A total 6412 consecutive patients were...
Background Serum uric acid (UA) is correlated closely with traditional cardiovascular risk factors, which might interfere the action of UA, in patients coronary artery disease. We performed this study to evaluate prognostic effect UA levels individuals different numbers standard modifiable factors (SMuRFs). Methods and Results In prospective study, we consecutively enrolled 10 486 They were stratified into 3 groups according tertiles concentrations and, within each tertile, further...
Background The prognostic effect of admission blood glucose (ABG) for patients with acute myocardial infarction (AMI) has not been well validated, especially in diabetes. We performed this study to assess the predictive value ABG all-cause mortality AMI different metabolism status. Methods evaluated a total 6,892 from prospective, nationwide, multicenter CAMI registry, which 2,820 had diabetes, 2,011 pre-diabetes, and 2,061 normal regulation (NGR). Patients were divided into high low groups...
To assess the correlation between triglyceride glucose (TyG) index and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI).A total of 2190 STEMI who underwent primary angiography within 12 h from symptom onset were selected prospective, nationwide, multicenter CAMI registry. TyG was calculated formula: Ln [fasting triglycerides (mmol/L) × fasting (mmol/L)/2]. Patients divided into three groups according to tertiles index. The endpoint mortality.Overall,...
The RESOLVE score is a validated angiographic scoring system to evaluate the risk of side branch (SB) occlusion in bifurcation intervention. However, inclusion quantitative coronary angiography (QCA)-derived parameters limits its use real-time procedures. We sought capability prediction SB based upon visually estimated (V-RESOLVE).The present study included all lesions (N=1,601) analysed for development and validation QCA-based score. An independent observer, blinded previous QCA data,...