A5100669601- Coronary Interventions and Diagnostics
- Head and Neck Cancer Studies
- Adipose Tissue and Metabolism
- Oral Health Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Gut microbiota and health
- Pleural and Pulmonary Diseases
- Facial Rejuvenation and Surgery Techniques
- GDF15 and Related Biomarkers
- Wound Healing and Treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Tracheal and airway disorders
- Reconstructive Surgery and Microvascular Techniques
- Epilepsy research and treatment
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Computational Drug Discovery Methods
Shanxi Medical University
2012-2025
Jiangnan University
2025
Sichuan University
2019-2025
West China Hospital of Sichuan University
2023-2025
Fujian Medical University
2013-2024
Shandong Provincial QianFoShan Hospital
2022-2024
Shandong First Medical University
2022-2024
Union Hospital
2013-2024
Capital Medical University
2024
Nanyang Institute of Technology
2024
Large-scale skin injuries are usually accompanied by impaired wound healing, resulting in scar formation, or significant morbidity and mortality. The aim of this study is to explore the vivo application 3D-printed tissue-engineered substitute using innovative biomaterial loaded with human adipose-derived stem cells (hADSCs) healing. Adipose tissue was decellularized, extracellular matrix components were lyophilized solubilized obtain adipose decellularized (dECM) pre-gel. newly designed...
Abstract Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation tumorigenicity limit its use. Exosomes, more stable immunogenicity‐reduced than parent have emerged promising avenue for IUA treatment....
The aim of this study was to use optical coherence tomography (OCT) predict newly implanted stent expansion for treatment in-stent restenosis (ISR).With OCT guidance, 143 ISR lesions were treated with a new stent. Stent underexpansion defined as minimum area (MSA) <4.5 mm2 and MSA/average reference lumen <70%. New found in 33 (23%). These had smaller old MSA (4.13 [3.32-4.62] versus 5.18 [4.01-6.38] mm2, p=0.001), higher prevalence multiple layers (51.5% 10.9%, p<0.001) neointimal or...
Oral squamous cell carcinoma is the most common type of malignant tumor in head and neck region. Despite advancements, metastasis recurrence rates remain high, patient survival has not significantly improved. Although miRNA therapies are promising for cancer gene therapy, their applications treating oral limited. Targeted medication delivery systems based on nanotechnology offer an efficient way to enhance treatment efficacy.
l-Asparagine (l-Asn) is an important amino acid with broad applications in food, medicine, fine chemicals, and environmental protection. However, its industrial production limited by the high cost of raw materials low catalytic efficiency enzymes. In this study, a three-enzyme cascade pathway (FDN) was designed to produce l-Asn, using fumaric as material. Within pathway, EcAsnA identified rate-limiting enzyme subsequently engineered product rescue strategy reduce inhibition opening closed...
Abstract Chinese hamster with characteristics is used in experiments, and it of great value the field medical biology research. However, at present, there no high‐efficiency method for evaluating genetic quality hamsters. Here, we developed a novel detection system using single‐nucleotide polymorphism (SNP) markers. To find SNP loci, conducted whole genome sequencing on 24 Then, employed an locus screening criterion that set up previously initially screened 214 loci wide distribution high...
CD4CD25 regulatory T cells (Tregs) play a key role in the prevention of various inflammatory and autoimmune disorders by suppressing immune responses. The beneficial effect statins on myocardial ischemia-reperfusion injury (IRI) depends part their immunomodulatory anti-inflammatory mechanisms. We aimed to determine whether Tregs contribute statin-induced cardioprotection against IRI.Thirty-two rats were divided into four groups: sham, (IR), rosuvastatin (RSV)/IR, mevalonic acid (MVA)+RSV/IR....
<h3>Background</h3> The tumor microenvironment (TME) is a complex mixture of epithelium, stroma and immune cells, the component TME highly prognostic for progression patient outcome. In lung cancer, anti-PD-1 therapy significantly improves survival through activation T cell cytotoxicity against cells. Direct contact between CD8+ cells target necessary activity, indicating that spatial organization within reflects critical process in anti-tumor immunity. Current immunohistochemistry (IHC)...
Abstract Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, role of miRNAs OSCC development and progression not well understood. Methods We sought to establish dynamic Chinese hamster animal model, construct miRNA differential expression profiles its occurrence development, predict targets, perform functional analysis validation vitro. Results Using...
Neurotoxicity can be resulted from many diverse clinical drugs, which has been a cause of concern to human populations across the world. The detection drug-induced neurotoxicity (DINeurot) potential with biological experimental methods always required lot budget and time. In addition, few studies have addressed structural characteristics neurotoxic chemicals. this study, we focused on computational modeling for machine learning insights into Based drug data effects, developed 35 different...
Angiogenesis has been considered a pivotal strategy for treating ischemic heart disease. One possible approach, the Shexiang Baoxin Pill (MUSKARDIA), noted to promote angiogenesis, but its underlying mechanism is still largely unknown. We aimed determine effects of MUSKARDIA on acute myocardial infarction (AMI), as well mechanistic bases. AMI was induced in rats, using left anterior descending coronary arterial occlusion, and either 6 (low) or 12 (high-dose) mg/kg/day administered 56 days....
Abstract MicroRNAs are known to play essential role in the gene expression regulation cancer. In our research, next-generation sequencing technology was applied explore abnormal miRNA of oral squamous cell carcinoma (OSCC) Chinese hamster. A total 3 novel miRNAs (Novel-117, Novel-118, and Novel-135) 11 (crg-miR-130b-3p, crg-miR-142-5p, crg-miR-21-3p, crg-miR-21-5p, crg-miR-542-3p, crg-miR-486-3p, crg-miR-499-5p, crg-miR-504, crg-miR-34c-5p, crg-miR-34b-5p crg-miR-34c-3p) were identified. We...
The aim of this study was to investigate the correlation between genetic polymorphisms azathioprine-metabolizing enzymes and adverse reactions myelosuppression. To end, a retrospective analysis performed on 1,419 Chinese patients involving 40 different diseases 3 genes: ITPA (94C&gt;A), TPMT*3 (T&gt;C), NUDT15 (415C&gt;T). Strict inclusion exclusion criteria were established collect relative cases, azathioprine myelosuppression evaluated by drug reaction criteria. mutation rates...
Abstract Background Management of cranial defects following failed cranioplasty due to titanium mesh exposure and infection is challenging. The purpose this report describe a modified technique using free myocutaneous flap transfer for primary soft tissue reconstruction, reinsertion revision. Methods Nineteen patients with were treated from January 2012 2019. average patient age was 41.89 years the size defect 7.74 × 13.92 cm. reasons craniotomy craniocerebral trauma ( n = 17),...
Haze problem is an important factor threatening human health. PM2.5 the main culprit haze. 1-Nitropyrene (1-NP) nitrated polycyclic aromatic hydrocarbon, toxic component of particles. The effects 1-NP on various organs and reproductive health have been extensively deeply studied, but embryo implantation endometrial receptivity remain to be determined. purpose this study was investigate adverse mouse receptivity. In early pregnancy, CD1 mice were given 2 mg/kg by oral gavage, which resulted...
Low temperatures pose a significant threat to plant growth and development. Studies have shown that aquaporins (AQPs), as the main functional proteins on cell membrane regulating water ingress egress, play vital role in maintaining dynamic balance when plants face cold stress. Catalpa bungei, an important timber ornamental tree species, has its cultivation range significantly limited by poor tolerance. However, no study been found aiming identify aquaporin gene family. This aims fill this...