A5034856810- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Pancreatic function and diabetes
- Reproductive System and Pregnancy
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Liver physiology and pathology
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Aortic Disease and Treatment Approaches
- Drug Transport and Resistance Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Pregnancy-related medical research
- Gynecological conditions and treatments
- Hydrogels: synthesis, properties, applications
- HVDC Systems and Fault Protection
- Osteoarthritis Treatment and Mechanisms
- Dendrimers and Hyperbranched Polymers
Shanxi Medical University
2021-2025
Nankai University
2016-2022
Life University
2016-2020
Abstract Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation tumorigenicity limit its use. Exosomes, more stable immunogenicity‐reduced than parent have emerged promising avenue for IUA treatment....
Cholestatic liver disease (CLD) is a severe disease, which can progress to cirrhosis, even cancer. Hepatic stellate cells (HSCs) activation plays crucial role in CLD development. Bone mesenchymal stem (BMSCs) treatment was demonstrated be beneficial diseases. However, the therapeutic effect and mechanism of BMSCs on are poorly known. In present study, we investigated effects underlying mechanisms transplantation mouse models bile duct ligation-induced cholestatic fibrosis (CLF). The results...
DOX-loaded peptide dendritic copolymer nanoparticles combat multidrug resistance of breast cancer cells by regulating the lysosomal pathway apoptosis.
The use of stem cell-based treatment systems is prevalent in regenerative medicine. To enhance the capabilities cells, growth factors are typically incorporated into system. Nonetheless, traditional hydrogel-encapsulated or heparinized scaffolds that bind have limitations. In this study, we prepared a biomaterial strategy using uniform poly(lactic-co-glycolic) acid (PLGA) microspheres (uPLGA-Ms) fabricated by microfluidic to sustain delivery insulin-like factor 1 (IGF-1), critical protein...
In an attempt to enhance endothelial cell capture and promote the vascularization of engineered tissue, we biosynthesized characterized recombinant fusion protein consisting human vascular endothelial-cadherin extracellular domain immunoglobulin IgG Fc region (hVE-cad-Fc) serve as a bioartificial matrix. The hVE-cad-Fc naturally formed homodimers was used construct matrix by stably adsorbing on polystyrene plates. Atomic force microscop assay showed uniform distribution with nanorod...
Mesenchymal stem cells (MSCs) have emerged as a promising source of multipotent for various cell-based therapies due to their unique properties, and formation 3D MSC aggregates has been explored potential strategy enhance therapeutic efficacy. In this study, poly(lactic-co-glycolic acid) (PLGA) microparticles modified with human E-cadherin fusion protein (hE-cad-PLGA microparticles) fabricated integrated MSCs form cell aggregates. The results show that, compared the plain PLGA, hE-cad-PLGA...
High-density hVE-cad-Fc substrates enhance Bel7402 cell VM capabilities through elevating endogenous VE-cadherin expression and its downstream signal transduction.
Haze problem is an important factor threatening human health. PM2.5 the main culprit haze. 1-Nitropyrene (1-NP) nitrated polycyclic aromatic hydrocarbon, toxic component of particles. The effects 1-NP on various organs and reproductive health have been extensively deeply studied, but embryo implantation endometrial receptivity remain to be determined. purpose this study was investigate adverse mouse receptivity. In early pregnancy, CD1 mice were given 2 mg/kg by oral gavage, which resulted...
To effectively expand human mesenchymal stem cells (hMSCs) in vitro without affecting their innate biological properties, a fusion protein (hE-cad-Fc) consisting of E-cadherin extracellular domain and an immunoglobulin G Fc region was fabricated used as biomimetic matrix for MSC culture surface modification. The results showed that cultured on hE-cad-Fc-modified polystyrene surfaces exhibited improved proliferation paracrine functions compared with unmodified collagen-modified surfaces....
<p indent="0mm">Alcoholic liver disease (ALD) poses a significant health challenge, so comprehensive research efforts to improve our understanding and treatment strategies are needed. However, the development of effective treatments is hindered by limitation existing models. Liver organoids, characterized their cellular complexity three-dimensional (3D) tissue structure closely resembling human liver, hold promise as ideal models for research. In this study, we use meticulously designed...
The activation of hepatic stellate cells (HSCs) is central to the occurrence and development liver fibrosis. Our previous studies showed that autophagy promotes HSC ultimately accelerates Unc-51-like activating kinase 1 (ULK1) an autophagic initiator in mammals,
Abstract Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), widely prescribed first-line antiepileptic drug for epilepsy various neurological conditions, has been associated with fourfold increase risk NTDs when used during pregnancy. Consequently, urgent efforts are required identify innovative prevention treatment approaches VPA-induced NTDs....
Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), widely prescribed first-line antiepileptic drug for epilepsy various neurological conditions, has been associated with 4-fold increase risk NTDs when used during pregnancy. Consequently, urgent efforts are required identify innovative prevention treatment approaches VPA-induced NTDs. Studies have...
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Abstract Vasculogenic mimicry (VM) describes a process by which tumor cells formed novel microcirculation pattern in an endothelial cell‐free manner. Clinically, VM is associated with aggressive phenotype and poor patient survival. However, the current models for investigating include 2D monolayer cultures, Matrigel‐based animal models, each of has limitations. often exhibit batch‐to‐batch variations, while vivo currently produce insufficient amounts VM. There no suitable model to discover...
Abstract Alcoholic liver disease (ALD) poses a significant health challenge, demanding comprehensive research efforts to enhance our comprehension and treatment strategies. However, the development of effective treatments is hindered by limitations existing models. Liver organoids, characterized their cellular complexity three-dimensional (3D) tissue structure closely resembling human liver, hold promise as ideal models for research. In this study, we employ meticulously designed protocol...
Abstract The activation of hepatic stellate cells (HSCs) is the central link in occurrence and development liver fibrosis. Our previous studies showed that autophagy promotes HSCs ultimately accelerates Unc-51-like activating kinase 1 (ULK1) an autophagic initiator mammals N 6 -methyladenosine (m A) modification closely related to autophagy. In this study, we find m A demethylase fat mass obesity-associated protein (FTO) upregulated during bile duct ligation (BDL)-induced fibrosis, which...