A5101575758- Vitamin D Research Studies
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Probiotics and Fermented Foods
- Human Health and Disease
- Air Quality and Health Impacts
- Vitamin C and Antioxidants Research
- Infant Nutrition and Health
- Pneumonia and Respiratory Infections
- Epilepsy research and treatment
- Birth, Development, and Health
- Smoking Behavior and Cessation
- Gut microbiota and health
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Climate Change and Health Impacts
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Digestive system and related health
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Viral-associated cancers and disorders
- Child Nutrition and Feeding Issues
- COVID-19 diagnosis using AI
- Diabetes Treatment and Management
Nanjing Tech University
2025
Chengdu Women's and Children's Central Hospital
2021-2024
University of Electronic Science and Technology of China
2021-2024
Shanxi Medical University
2023-2024
First Hospital of Shanxi Medical University
2024
Harbin Medical University
2018-2024
Shanghai First People's Hospital
2022
Shanghai University of Medicine and Health Sciences
2020
Changhai Hospital
2017
Ningbo University
2016-2017
Objective: To assess the health-related economic burden attributable to smoking in China for persons aged 35 and older. Methods: A prevalence-based, disease-specific approach was used estimate direct costs, indirect morbidity costs of premature deaths caused by smoking-related diseases. The primary data source 1998 National Health Services Survey, which contains status, medical utilisation, expenditures 216 101 individuals. Results: 2000 amounted $5.0 billion (measured 2000, US$) total...
Objectives: To explore whether lower outdoor temperature increases cardio-cerebrovascular disease risk through regulating blood pressure and indoor heating in winter is beneficial to prevent cold areas. Methods: We analyzed the data of 38 589 participants Harbin from China Kadoorie Biobank (CKB) during 2004–2008, with an average 7.14-year follow-up. Linear regression analysis was performed estimate relationship between pressure. Cox logistic were used analyze association event risk....
Abstract The goal of this study is to assess the efficacy and safety Bifidobacterium animalis subsp. lactis BLa80, as an adjunct treatment for diarrhea in children with a randomized, double-blinded, placebo-controlled design. Eligible diarrheal children, aged 0–3 years without need antibiotic based on clinical diagnosis when recruited, were randomized into intervention group (IG, n = 58, probiotic) or control (CG, 53, placebo). primary assessment was duration diarrhea. Fecal samples...
The effects of flavonoids and copper (Cu) on metabolic syndrome (MetS) have been investigated separately, but no information exists about the joint associations between Cu risk MetS in population studies. In this cross-sectional study, a total 9108 people aged 20⁻75 years from Harbin Cohort Study Diet, Nutrition, Chronic Non-Communicable Diseases (HDNNCDS) were included. Flavonoid intakes calculated based flavonoid database created our laboratory. other nutrient estimated using Chinese Food...
Abstract The aim was to systematically analyse the association of specific flavonoids, Mg and their interactions from different food sources with metabolic syndrome (MetS) its components in a cohort study. A total 6417 participants aged 20 74 years Harbin Cohort Study on Diet, Nutrition Chronic Non-communicable Diseases were included. Multivariate logistic regression analyses, forest plot restricted cubic spline performed After 5·3-year follow-up, 1283 incident cases MetS reported. Those...
This study aimed to explore the temporal relationship between blood glucose, lipids and body mass index (BMI), their impacts on atherosclerosis (AS). A prospective cohort was designed. total of 2659 subjects from Harbin Cohort Study Diet, Nutrition Chronic Non-communicable Diseases, aged 20 74 years were included. Body weight, height, fasting glucose (FBG) 2-hour postprandial (2-h PG), including cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-c) high-density (HDL-c)...
Abstract Background Living at high latitudes is one of the risk factors for vitamin D deficiency in children. However, evidence on improvement this pediatric population to date limited. This study aims evaluating association different intervention methods and outdoor activity status children North China. Methods In observational study, a total 55,925 aged 1 month 18 years old were recruited from outpatient departments July 2016 June 2017. Data demographics, anthropometric measurements,...
The outbreak of SARS-CoV-2 at the end 2019 sounded alarm for early inspection on acute respiratory infection (ARI). However, diagnosis pathway ARI has still not reached a consensus and its impact prognosis needs to be further explored.ESAR is multicenter, open-label, randomized controlled, non-inferiority clinical trial evaluating performance between mNGS multiplex PCR. Enrolled patients will divided into two groups with ratio 1:1. Group I directly tested by mNGS. II firstly receive PCR,...
Abstract Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), widely prescribed first-line antiepileptic drug for epilepsy various neurological conditions, has been associated with fourfold increase risk NTDs when used during pregnancy. Consequently, urgent efforts are required identify innovative prevention treatment approaches VPA-induced NTDs....
Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), widely prescribed first-line antiepileptic drug for epilepsy various neurological conditions, has been associated with 4-fold increase risk NTDs when used during pregnancy. Consequently, urgent efforts are required identify innovative prevention treatment approaches VPA-induced NTDs. Studies have...
This study aimed to explore the vitamin D status of children in northern China and association between glucose metabolism. Cross-sectional was conducted among child participants retrospective designs were adult participants. Both studies recruited from Harbin, 326 included children's study, 8469 adults study. Physical examination, lifestyle dietary habit data recorded all Serum insulin, glucose, 25(OH)D3 concentrations serum lipids levels measured. Rickets history also investigated adults,...
Functional constipation (FC) can seriously affect the physical and mental health of children. The goal this study is to assess efficacy safety Bifidobacterium animalis subsp. lactis XLTG11 in treating FC children through a randomized, double-blinded, placebo-controlled approach. Eligible were randomized into either intervention group (IG, n = 65, receiving conventional treatment with probiotics) or control (CG, 66, without probiotics). primary outcome measure was fecal frequency. Fecal gut...
To investigate the expression of P-glycoprotein in T-cell subpopulations lymphocytes from adult patients with refractory glomerulonephritis (GN).
Introduction The goal of this study is to assess the efficacy and safety Lacticaseibacillus rhamnosus LRa05, as an adjunct treatment acute watery diarrhea in children. Methods Eligible diarrheal children were randomized into intervention group (IG, n = 57) control (CG, 54), given probiotics or placebo, respectively. Results total duration IG (121.4 ± 13.7 h) was significantly shorter than that CG (143.9 19.8 h, p < 0.001). More showed improvements those for both per protocol analysis...
Objective: To study the relations between famine exposure and risk of chronic diseases as diabetes mellitus, obesity, hypertension, coronary heart disease stroke in population Harbin. Methods: Our data was collected from baseline survey-the China Kadoorie Biobank project (CKB) Retrospective cohort design used. Related risks on including stroke, were compared among exposed or non-exposed people, respectively by logistic analysis method. Results: After adjusted for factors age, sex, physical...
Objective To comparative analyze the influence factors of short-term (6 months) and long-term (10 years) prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF), to provide some reference values on clinic therapy follow-up management. Methods The data 524 hospitalized ACLF from January 2001 December 2009 were analyzed retrospectively. The termination time was 2013. Patients all given internal medical therapy, antiviral nucleoside nucleotide analogs (NAs) (yes/no)...
e14040 Background: Immature myeloid cells or the so called Myeloid-derived suppressor (MDSCs) are found to be present in higher numbers cancer patients' PBMCs and tumor infiltrating cells. All-trans retinoic acid (ATRA) is a natural vitamin A metabolite that's capable of inducing MDSC maturation differentiation at uM concentrations. HF1K16 an ATRA liposome formulation developed by Hangzhou Highfield Biopharm that aims deliver microenvironment i.v. infusion for mediated immuno-therapeutic...
Objective To investigate the intensity of HBsAg and HBcAg expression in liver tissue patients with chronic hepatitis B virus (HBV) infection its clinical significance. Methods A total 994 HBV infected underwent biopsy histopathological examination. The was detected by histoimmunochemistry. Patients were divided into HBeAg(+ )/HBVDNA(+ ), HBeAg(-)/HBV DNA(+ ) DNA(-) groups according to HBeAg DNA levels; <2×normal (ULN) group, 2-<5×ULN group ≥5×ULN alanine aminotransferase (ALT) levels....
Abstract Background Living at high latitudes is one of the risk factors for vitamin D deficiency in children. However, evidence on improvement this pediatric population to date limited. This study aims evaluating effect different supplementation methods and outdoor activity time status children North China. Methods A total 55,925 aged 1 month 18 years old were recruited from outpatient departments July 2016 June 2017. Data demographics, anthropometric measurements, supplementation, recorded....