A5045944354- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemokine receptors and signaling
- Inflammation biomarkers and pathways
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Immune responses and vaccinations
- Systemic Lupus Erythematosus Research
- Urticaria and Related Conditions
- Memory and Neural Mechanisms
- Herpesvirus Infections and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
First Affiliated Hospital of Xiamen University
2023-2024
First Hospital of Shanxi Medical University
2024
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Guilin Medical University
2013-2022
Synaptic dysfunction is an important pathological hallmark and cause of Alzheimer's disease (AD). High-frequency stimulation (HFS)-induced long-term potentiation (LTP) has been widely used to study synaptic plasticity, with impaired LTP found be associated AD. However, the exact molecular mechanism underlying plasticity yet completely elucidated. Whether genes regulating are altered in AD contribute onset also remains unclear. Herein, we induced hippocampal CA1 region wild-type (WT) model...
Abstract Background The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton trafficking. Single nucleotide polymorphisms (SNPs) the CD2AP gene have been associated with Alzheimer’s disease (AD). However, functional role of CD2AP, especially its microglia during AD onset, remains elusive. Methods levels cultured primary 5xFAD mice studied. Microglial CD2AP-deficient were crossed offspring subjected to neuropathological assessment,...
Objective To estimate the relationship ot herpes simplex virus (HSV) shedding with serum anti-herpes antibody levels and antiviral treatment in patients asymptomatic genital herpes.Methods Totally,650 were enrolled this study.Swab samples collected from urethral,genital,perianal mucosa extragenital sites of previous HSV infection,and venous blood also obtained these patients.Fluorescence-based quantitative PCR was performed to detect DNA determine copy number plasmid DNA,enzyme-linked...
Objective: Systemic lupus erythematosus (SLE) displays the characteristics of abnormal activity immune system, contributing to diverse clinical symptoms. Herein, this study was conducted for discovering novel cell-relevant therapeutic targets. Methods: The abundance cells estimated in PBMCs SLE and healthy controls from GSE50772 dataset with CIBERSORT approach. Immune co-expression modules were screened WGCNA relevant characteristic genes determined LASSO algorithm. Inflammatory chemokines...