A5089383647- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Liver physiology and pathology
- Plant Virus Research Studies
- Pancreatic function and diabetes
- Bone Tissue Engineering Materials
- Dendrimers and Hyperbranched Polymers
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Membrane Separation Technologies
- Plant Disease Resistance and Genetics
- Periodontal Regeneration and Treatments
- Plant Genetic and Mutation Studies
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Trace Elements in Health
- Wound Healing and Treatments
- Angiogenesis and VEGF in Cancer
- Plant and Fungal Interactions Research
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Selenium in Biological Systems
Beijing Institute of Technology
2017-2025
Anhui Medical University
2025
He Eye Hospital
2025
Peking University Shenzhen Hospital
2023-2024
University of Chinese Academy of Sciences
2024
Nankai University
2014-2023
Second Hospital of Shanxi Medical University
2022
Shanxi Medical University
2022
Life University
2016-2021
Hangzhou Normal University
2021
The development of natural polymer-based hydrogels, combining outstanding injectability, self-healing, and tissue adhesion, with mechanical performance, able to facilitate full-thickness skin wound healing, remains challenging. We have developed an injectable micellar hydrogel (AF127/HA-ADH/OHA-Dop) adhesive self-healing properties accelerate healing. Dopamine-functionalized oxidized hyaluronic acid (OHA-Dop), adipic dihydrazide-modified HA (HA-ADH), aldehyde-terminated Pluronic F127 (AF127)...
Selenoprotein P is a plasma protein recently purified and characterized as containing 7.5 +/- 1.0 selenium atoms/molecule selenocysteine. In rats maintained on defined diet nutritionally adequate amounts of selenate the sole source, over half in accounted for by selenoprotein P. Its cDNA has been cloned from rat liver library sequenced. The sequence highly unusual, 10 TGA codons its open reading frame prior to TAA termination codon. designates selenocysteine other selenoproteins, limited...
Selenoprotein P is the second plasma selenoprotein to be purified. It a glycoprotein and has been shown distinct from glutathione peroxidase. This study characterizes further. Deglycosylation of protein shifts its migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis Mr 57,000 43,000, indicating it substantial carbohydrate component. Measurement selenium indicates content 7.5 +/- 1.0 atoms/molecule based polypeptide weight 43,000. Amino acid analysis accounts for all as...
Abstract Precisely delivering siRNA to its target site in cancer cells is a high‐demanding but challenging task. Herein, biomimetic magnetosome developed using magnetic nanocluster (MNC) as the core and Arg–Gly–Asp (RGD) decorated macrophage membrane cloak, which achieved via combination of MNC synthesis, azide‐membrane engineering, electrical assembly, click chemistry. Such feature‐packed enables us gain success high‐performance delivery through superior stealth effect, resonance imaging,...
Mesenchymal stem cells (MSCs) from adult bone marrow maintain their self-renewal ability and the to differentiate into osteoblast. Thus, MSCs play a key role in regeneration of tissue. Previous studies indicated that TLR4 is expressed critical regulating fate decision MSCs. However, exact functional underlying mechanisms how regulate MSC proliferation differentiation are unclear. Here, we found activated by its ligand LPS promoted osteogenic vitro. activation also increased cytokine IL-6...
Due to the inconvenience of application, risk extra damage fragile soft tissues, and high incidence late-stage complications, significant research endeavors have been focused on developing safe effective bioadhesives replace or assist traditional suture techniques for wound closure. Here, we describe a fast strength bioadhesive based polysaccharides peptide dendrimers (OCMC/G3KP) with inherent hemostatic ability antibacterial properties. Compared commercial Coseal, OCMC/G3KP hydrogel shows...
The emergence and innovation of three-dimensional (3D) bioprinting provide new development opportunities for tissue engineering regenerative medicine. However, how to obtain bioinks with both biomimicry manufacturability remains a great issue in 3D bioprinting. Developing intelligent responsive biomaterials is conducive break through the current dilemma. Herein, stepwise multi-cross-linking strategy concerning thermosensitive thiolated Pluronic F127 (PF127-SH) hyaluronic acid methacrylate...
Studies with 75Se have shown the existence of a rat plasma selenoprotein in addition to glutathione peroxidase. Because function protein is not known, it has been referred as P. A partially purified preparation was used produce monoclonal antibody The did bind peroxidase evidenced by its failure remove activity from immunoprecipitation. An immunoaffinity column prepared antibody, and P 1270-fold two-step procedure. migrated single band an Mr 57,000 on sodium dodecyl sulfate-polyacrylamide...
Conventional strategies of stem cell injection in treating myocardial infarction (MI) remain a challenge because low retention rate and insufficient secretion exogenous cytokines for efficiently improving the microenvironment infarcted myocardium, thus hampering therapeutic effect. Herein, poly(lactic-co-glycolic acid) (PLGA) microparticles modified with human VE-cad-Fc fusion protein are fabricated integrated mesenchymal cells (hMSCs) to construct functionalized MSC aggregates (FMAs). This...
Feeder cells like mouse embryonic fibroblasts (MEFs) have been widely applied for culture of pluripotent stem cells, but their roles remain elusive. Noticeably, ESCs cultured on the feeders display transcriptional heterogeneity. We investigated feeder by examining telomere maintenance. Here we show that is longer in mESCs with than without feeders. mESC cultures MEF exhibit loss, chromosomal fusion, and aneuploidy increasing passages. Notably, facilitate heterogeneous transcription 2-cell...
Smart polymers as ideal gene carriers have drawn increasing attentions due to the effective DNA release once triggered by intrinsic stimuli, well reduced cytotoxicity. Herein, a stimulus-responsive, positively charged and water-soluble polymer (OEI-TKx) was facilely engineered cross-linking low molecular weight oligoethylenimine (OEI) via thioketal (TK) linkages that would cleave selectively in reactive oxygen species (ROS)-rich environments induced hypoxia. Agarose gel electrophoresis assay...