A5076206515- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Liquid Crystal Research Advancements
- 3D Printing in Biomedical Research
- Marine Sponges and Natural Products
- Polymer composites and self-healing
- Corneal Surgery and Treatments
- Photochromic and Fluorescence Chemistry
- Ocular Surface and Contact Lens
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Muscle Physiology and Disorders
- Angiogenesis and VEGF in Cancer
- Advanced Sensor and Energy Harvesting Materials
- Ginseng Biological Effects and Applications
- Proteoglycans and glycosaminoglycans research
- Corneal surgery and disorders
- Photonic Crystals and Applications
- Polymer Surface Interaction Studies
- Optical Coherence Tomography Applications
- RNA and protein synthesis mechanisms
- Graphene and Nanomaterials Applications
- Advanced Fluorescence Microscopy Techniques
- Supramolecular Self-Assembly in Materials
Forest Institute
2012-2018
Wake Forest University
2012-2017
California Institute for Regenerative Medicine
2016
Atrium Health Wake Forest Baptist
2014-2016
Weatherford College
2014
University of Science and Technology Beijing
2008-2011
Hebrew University of Jerusalem
2011
I-Shou University
2008
Changchun Institute of Technology
2007
Institute of Process Engineering
2001-2005
A blue phase with a broad temperature range of about 23.0 °C is easily achieved in hydrogen-bonded self-assembled complex chiral fluoro-substituted benzoic acid and pyridine derivative. The success extending the indicates that self-assembly promising new approach to broaden phases investigate mystery phases.
Objectives: Our study aims at producing acellular extracellular matrix scaffolds from the human pancreas (hpaECMs) as a first critical step toward production of new-generation, fully human-derived bioartificial endocrine pancreas. In this pancreas, hardware will be represented by hpaECMs, whereas software consist in cellular compartment generated patient's own cells. Background: Extracellular (ECM)-based obtained through decellularization native organs have become favored platform field...
Abstract This work describes a comprehensive study of hydrogels based on polyethylene glycol diacrylates (PEGDAs) with the molecular weight (MW) range 400–2000. The blends low‐ and high‐molecular PEGDA macromers different ratios were photopolymerized under visible light irradiation, using blue sensitive photoinitiator Irgacure819, at total polymer concentration 60 wt %. Swelling ratios, wetting property, elastic moduli, transparency, microstructure resulting investigated. Among them,...
Objective: To evaluate the mechanical property and biocompatibility of Wnt pathway inhibitor (ICG-001) delivering collagen/poly(l-lactide-co-caprolactone) (P(LLA-CL)) scaffold for urethroplasty, also feasibility inhibiting extracellular matrix (ECM) expression in vitro vivo. Methods: ICG-001 (1 mg (2 mM)) was loaded into a with co-axial electrospinning technique. The characteristics drug release fashion scaffolds were tested testing machine (Instron) high-performance liquid chromatography...
The reactive thermal-sensitive hydrogels, which combined the reversible thermosensitive and mild property, were designed based on thiol-ene reaction in physiological conditions between thiol acrylate capped Poloxamer 188. modified P188A, P188SH, their reactivity characterized by 1H NMR, FT-IR, GPC, DSC, Ellman method, Rheometer. It was found that pH thermal-sensitive. There 77.7% SH involved into at 37.0 °C 7.4 within first 30 min. most of molecules reacted as C═C/SH mol ratio 1.5....
Corneal transplantation has become a common procedure to improve visual acuity by replacing the opaque or distorted host tissue with clear healthy donor corneal tissue. However, globally its wide spread clinical utility is limited due lack of supply high quality corneas. Bioengineered neo-corneas using discarded human corneas isolate endothelial and epithelial cells, as well stroma scaffolding material, could help address this shortage. The objective study was fabricate multilayered...
The argonaute protein from the thermophilic bacterium Thermus thermophilus shows DNA-guided DNA interfering activity at high temperatures, complicating its application in mammalian cells. A recent work reported that Natronobacterium gregoryi (NgAgo) had genome editing We compared activities of NgAgo and Staphylococcus aureus Cas9 (SaCas9) human HEK293T cells side by side. EGFP reporter assays sequencing consistently revealed SaCas9. However, these did not demonstrate NgAgo. confirmed...
Abstract The unique features of shape‐memory polymers enables their use in minimally invasive surgical procedures with a compact starting material switching over to voluminous structure vivo. In this work, series transparent, thermoset (meth)acrylate polymer networks tailored thermomechanics have been synthesized and evaluated. Fundamental trends were established for the effect crosslinker content molecular weight on glass transition temperature, rubbery modulus shape‐recovery behavior,...
A series of novel transparent shape memory co-polymers, made from (meth)acrylate monomers, intended to be used as intraocular lens, was synthesized. The thermo-mechanical properties, properties and optical the co-polymers could adjusted by using monomers with various alkyl chain lengths. cytocompatibility prepared L929 mouse connective tissue fibroblasts demonstrated in vitro, exhibited favorable cytocompatibility, supporting cell viability proliferation. This study showed that which good...
Abstract The thiol‐ene photopolymerization, which could be achieved with less ultraviolet (UV) intensity and photoinitiator content was first introduced into the application of injectable intraocular lenses (IOLs), thus damages to eye from UV radiation toxicity were greatly reduced. bulk samples obtained mixture poly(ethylene glycol) diacrylate (PEGDA) pentaerythritol tetrakis(3‐mercaptopropionate) (PTMP) by photopolymerization. It found that PEGDA‐PTMP had similar transparency...
Abstract Background and Objective Regenerative medicine involves the bioengineering of a functional tissue or organ by seeding living cells on biodegradable scaffold cultured in bioreactor. A major barrier to creating tissues, however, has been inability monitor dynamic complex process maturation real time, making control optimization extremely difficult. Current methods assess bioengineered constructs, such as histology bath physiology, are sample‐destructive. Optical coherence tomography...
Fluorescent imaging is a useful tool to monitor and evaluate bioengineered tissues organs. However, autofluorescence emitted from the scaffold can be comparable or even overwhelm signals generated by fluorescently labelled cells biomarkers. Using standard fluorescent microscopy techniques, simple easy-to-measure signal noise ratio metric was developed, which facilitate selection of biomarkers respective biomaterials for tissue engineering studies. Endothelial (MS1) expressing...