A5100711456- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Photodynamic Therapy Research Studies
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Sulfur Compounds in Biology
- Synthesis and Reactions of Organic Compounds
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Radioactive element chemistry and processing
- Electrochemical sensors and biosensors
- Immune cells in cancer
- Photoacoustic and Ultrasonic Imaging
- Water Quality Monitoring and Analysis
- Nanoparticle-Based Drug Delivery
- Mass Spectrometry Techniques and Applications
- Pediatric health and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Inorganic and Organometallic Chemistry
Shanxi Medical University
2018-2025
Affiliated Hospital of Southwest Medical University
2025
Jiujiang University
2024
Affiliated Hospital of Guizhou Medical University
2022-2024
Guiyang Medical University
2024
Xiamen University
2017-2023
Nanchang University
2021-2023
Shanghai University of Engineering Science
2022
Henan Agricultural University
2022
Henan University
2022
HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a new sensitive mitochondrial-targeting fluorescent probe.
Monoamine oxidase A (MAO-A) is known to widely exist in most cell lines the body, and its dysfunction (unusually high or low levels of MAO-A) thought be responsible for several psychiatric neurological disorders. Thus, a sensitive selective method evaluating relative MAO-A different live cells urgently needed better understand function MAO-A, but our knowledge such still lacking. Herein, we rationally design two new ratiometric fluorescence probes (1 2) that can sensitively selectively...
A new sensitive fluorescent probe with long analytical wavelengths for γ-glutamyl transpeptidase (GGT) assay has been developed by incorporating the group as a recognition unit into fluorophore of cresyl violet (CV). The detection mechanism is based on GGT-catalyzed cleavage group, followed release CV, which leads to distinct color change from light yellow pink and large fluorescence enhancement at 615 nm (λex = 585 nm). Under optimized conditions, intensity directly proportional activity...
Abstract A lysosome‐targeting fluorescent off‐on probe has been developed by one‐step synthesis for detecting lysosomal nitroreductase and hypoxia. The is constructed incorporating morpholine (a unit) into 4‐nitro‐1,8‐naphthalimide (as a fluorochrome specific substrate nitroreductase), the detection mechanism based on nitroreductase‐catalyzed reduction of to 4‐amino‐1,8‐naphthalimide, accompanied large fluorescence enhancement at wavelength 543 nm. shows an accurate ability with high...
Triple negative breast cancer (TNBC) is the most aggressive subtype of cancer, with ineffective treatment and poor prognosis. It in great demand to develop a novel theranostic strategy for accurate diagnosis targeted TNBC. In present study, one nanoplatform (HA-ICG-Fe-PDA), endowed multimodal imaging-guided chemodynamic/photodynamic/photothermal (CDT/PDT/PTT) synergistic therapy capacity toward TNBC, was innovatively constructed. The prepared by covalently conjugating ICG-decorated...
A photoelectrochemical probe for rapid determination of chemical oxygen demand (COD) is developed using a nanostructured mixed-phase TiO2 photoanode, namely PeCOD probe. UV-LED light source and USB mircroelectrochemical station are powered controlled by laptop computer, which makes the portable onsite COD analyses. The measurement was optimized in terms intensity, applied bias, pH. Under conditions, net steady state currents originated from oxidation organic compounds were found to be...
Colon cancer is one kind of malignant digestive tract tumor with high morbidity and mortality worldwide, treatments for which still face great challenges. Recently emerged intervention strategies such as phototherapy gas therapy have displayed promising effects in the treatment colon cancer, but their application are hindered due to insufficient targeting deeper tissue penetrating capacity. Herein, present study, we developed theranostic nanoplatform Cet-CDs-SNO (CCS) realize multimodal...
Abstract Triple negative breast cancer (TNBC) remains a challenge for clinical diagnosis and therapy due to its poor prognosis high mortality rate. Hence, new methods achieve TNBC imaging imaging-guided are urgently needed. Currently, the combination of chemotherapy with phototherapy/catalytic has become promising strategy treatment. Here, multifunctional CuFeSe 2 ternary nanozymes (CuFeSe -AMD3100-Gem nanosheets) were prepared as high-performance nanotheranostic agents synergistic in vitro...
Correlated analysis of multiple biochemical parameters at the single-particle level and in a high-throughput manner is essential for insights into diversity functions biological nanoparticles (BNPs), such as bacteria subcellular organelles. To meet this challenge, we developed highly sensitive spectral nano-flow cytometer (S-nFCM) by integrating recording module to laboratory-built nFCM that 4–6 orders magnitude more side scattering detection 1–2 fluorescence than conventional flow...
Gold nanoparticles are functionalized as a nanoprobe with cresyl violet and porphyrin via hyaluronic acid. The becomes highly fluorescent in the presence of hyaluronidase or under ultraviolet irradiation, can be used to target cancer cells overexpressed CD44 receptor for fluorescence imaging phototherapy.
As the sixth leading cause of cancer death, esophageal is threatening life people worldwide. Traditional treatments, such as surgery, chemotherapy, radiotherapy, are facing always augmented challenges including invasion, multidrug resistance (MDR), off-target toxicity. Chemo & Photodynamic synergistic therapy represents one promising strategy for improved treatment efficiency. But it still hindered by lack tumor targeting, deleterious side effects, and unfavorable microenvironment...
Abstract MicroRNAs are known to play essential role in the gene expression regulation cancer. In our research, next-generation sequencing technology was applied explore abnormal miRNA of oral squamous cell carcinoma (OSCC) Chinese hamster. A total 3 novel miRNAs (Novel-117, Novel-118, and Novel-135) 11 (crg-miR-130b-3p, crg-miR-142-5p, crg-miR-21-3p, crg-miR-21-5p, crg-miR-542-3p, crg-miR-486-3p, crg-miR-499-5p, crg-miR-504, crg-miR-34c-5p, crg-miR-34b-5p crg-miR-34c-3p) were identified. We...