A5062440498- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Nanoplatforms for cancer theranostics
- MRI in cancer diagnosis
- Epistemology, Ethics, and Metaphysics
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Geomechanics and Mining Engineering
- Wittgensteinian philosophy and applications
- Photoacoustic and Ultrasonic Imaging
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Philosophy and History of Science
- Graphene and Nanomaterials Applications
- Coronary Interventions and Diagnostics
- Nanocluster Synthesis and Applications
- Amino Acid Enzymes and Metabolism
- Technology and Security Systems
- RNA Research and Splicing
- Diet and metabolism studies
Northeast Normal University
2020-2025
University of Pennsylvania
2018-2025
Translational Therapeutics (United States)
2020-2025
Shanxi Medical University
2024-2025
First Hospital of Shanxi Medical University
2024-2025
Anhui University
2025
Chongqing Construction Engineering Investment Holding (China)
2025
Cancer Research UK
2023-2024
Tsinghua University
2024
Ningbo University
2024
Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core–shell (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, melanin-like mimic of mussel adhesive proteins, can self-polymerize form surface-adherent polydopamine (PDA) films onto wide range materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides number...
A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance (MRI) dual-modal imaging. Moreover, the Se8-DOX shows pH-responsive chemotherapy and enables combination of photothermal therapy to receive superior antitumor efficacy. This work promises further exploration 2D nanoplatforms applications. As a service our authors readers, this journal...
This study aims to explore non-invasive imaging of atherosclerotic plaque through magnetic resonance (MRI) and near-infrared fluorescence (NIRF) by using profilin-1 targeted iron oxide nanoparticles (PF1-Cy5.5-DMSA-Fe3O4-NPs, denoted as PC-NPs) multimodality molecular probe in murine model atherosclerosis.PC-NPs were constructed conjugating polyclonal antibody NHS-Cy5.5 fluorescent dye the surface DMSA-Fe3O4-nanoparticles via condensation reaction. Murine atherosclerosis was induced...
A simple and versatile nanoparticulate siRNA DNA delivery vehicle is reported, based on photonic Cdots by using Alkyl–PEI2k for surface passivation.
Abstract Metabolic subtypes of glioblastoma (GBM) have different prognoses and responses to treatment. Deuterium metabolic imaging with 2H-labeled substrates is a potential approach stratify patients into for targeted In this study, we used 2H magnetic resonance spectroscopy spectroscopic (MRSI) measurements [6,6′-2H2]glucose metabolism identify their chemoradiotherapy in patient-derived GBM xenografts vivo. The cells was first characterized vitro by measuring the oxygen consumption rate,...
Photothermal therapy (PTT) and photodynamic (PDT) are promising cancer treatment modalities. Because each modality has its own set of advantages limitations, there been interest in developing methods that can co-deliver the two regimens for enhanced tumor treatment. Among efforts, nano-graphene oxide-mediated phototherapies have recently attracted much attention. Nano-graphene oxide a broad absorbance spectrum be loaded with photosensitizers, such as chlorin e6, high efficiency. Chlorin...
<title>Abstract</title> Faced with the dual challenges of coal mining under buildings, railways, and water bodies, as well shortage backfill materials, guided by basic principles more mining, less backfilling, effective roof control, a technical concept inclination strike <italic>in situ</italic> strip interval paste in goaf was proposed, mechanical model collaborative control established for backfill. Also, effects main controlling factors such uniformly distributed load on overburden,...
In spite of rapidly increasing interest in the use nanoparticle-mediated photothermal therapy (PTT) for treatment different types tumors, very little is known on early treatment-related changes tumor response.Using graphene oxide (GO) as a model nanoparticle (NP), this study, we tracked tumors after GO NP-mediated PTT by magnetic resonance imaging (MRI) and quantitatively identified MRI multiple parameters to assess dynamic signal at heating levels duration.We found time-and...
The dense stroma underlies the drug resistance of pancreatic ductal adenocarcinoma (PDA) and has motivated development stroma-directed drugs. Our objective is to test concept that dynamic contrast-enhanced (DCE) MRI using FDA-approved contrast media, an imaging method sensitive tumor microenvironment, can detect early responses drug.Imaging studies were performed in three mouse models exhibiting high desmoplastic reactions: autochthonous PDA genetically engineered mice (KPC), orthotopic...
Colon cancer is one kind of malignant digestive tract tumor with high morbidity and mortality worldwide, treatments for which still face great challenges. Recently emerged intervention strategies such as phototherapy gas therapy have displayed promising effects in the treatment colon cancer, but their application are hindered due to insufficient targeting deeper tissue penetrating capacity. Herein, present study, we developed theranostic nanoplatform Cet-CDs-SNO (CCS) realize multimodal...
Low-density lipoprotein (LDL) is the primary natural carrier of lipids in bloodstream and plays a central role development atherosclerosis. By leveraging LDL's tendency to accumulate at sites plaque formation, LDL can be employed as selectively deliver imaging probes efficiently detect atherosclerotic plaques. In our previous studies, we reported several LDL-based magnetic resonance contrast agents (MRI-CAs) formed by modifying (nLDL) or developing LDL-mimetic (synthetic LDL, sLDL) from...
Abstract Protective inhibition (PI) behavior is critical to human self‐protection by reducing the physiological arousal of overloaded stimulation. Neuromorphic hardware mimicking PI can facilitate advancements in field bio‐realistic artificial intelligence and remains be studied. Herein, a specially engineered complementary memristor with limited Cu embedding porous amorphous carbon proposed emulate behavior. The depletion produces switching behavior, sharing similarities response its...
Aims This study aimed to evaluate the impact of early exercise following acute myocardial infarction (AMI) on cardiac function, remodeling, glucose metabolism, and its molecular changes using magnetic resonance (CMR) imaging positron emission tomography (PET). Methods results Thirteen rats (MI-exercise, MIE) underwent an 8-week treadmill training initiated 1 week after AMI. Longitudinal assessments were conducted 7T CMR 18 F-FDG PET/CT at baseline, 4 weeks 8 commencement exercise. Molecular...
Stem cell based therapies offer significant potential in the field of regenerative medicine. The development superparamagnetic iron oxide (SPIO) nanoparticle labeling and magnetic resonance imaging (MRI) have been increasingly used to track transplanted cells, enabling vivo determination fate. However, impact SPIO-labeling on phenotype differentiation capacity embryonic stem cells (ESCs) remains unclear. In this study, we wrapped SPIO nanoparticles with stearic acid grafted PEI600, termed as...
LDL-mimetic lipid nanoparticles, decorated with MRI contrast agents and fluorescent dyes, were prepared by the covalent attachments of an apoB100-mimetic peptide, Gd(<sc>iii</sc>)-chelate, rhodamine to enhance atherosclerosis in the<italic>in vivo</italic>imaging.
Major depressive disorder (MDD) presents with two primary symptoms: depressed mood and anhedonia, which suggests that distinct neuronal circuits may regulate MDD. However, the underlying of these individual symptoms linked to depression remain elusive. Herein, we identify a discrete circuit tachykinin precursor 1 (Tac1)-expressing neurons in nucleus accumbens (NAc) lateral shell, project ventral pallidum contribute stress-induced anhedonia-like behavior. Selective inhibition activation...
SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of COVID-19. Our research, along with others', has demonstrated that mast cells (MCs) play vital role in the initiation caused by SARS-CoV-2. In previous study, we observed infection induced accumulation MCs peri-bronchus and bronchioalveolar-duct junction humanized mice. Additionally, found MC degranulation triggered spike protein resulted inflammation alveolar epithelial capillary endothelial cells, leading to...