A5100402987- Pancreatic function and diabetes
- Inorganic Fluorides and Related Compounds
- Receptor Mechanisms and Signaling
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Ion channel regulation and function
- Diabetes and associated disorders
- Asymmetric Synthesis and Catalysis
- Advanced Chemical Physics Studies
- Free Radicals and Antioxidants
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Computational Drug Discovery Methods
- Layered Double Hydroxides Synthesis and Applications
- Diabetes Management and Research
- Molecular Spectroscopy and Structure
- Adipose Tissue and Metabolism
- Atmospheric Ozone and Climate
- Nonlinear Optical Materials Research
- Synthesis and Catalytic Reactions
- Calcium signaling and nucleotide metabolism
- Drug Transport and Resistance Mechanisms
- Fungal Plant Pathogen Control
- Carbon and Quantum Dots Applications
- Photodynamic Therapy Research Studies
Shanxi Medical University
2018-2025
Jilin University
2024
Shanghai East Hospital
2024
University of South China
2019
Xinjiang Technical Institute of Physics & Chemistry
2019
Logistics University of People's Armed Police Force
2015
Chinese People's Armed Police Force
2015
Kyushu University
2014
Virginia Commonwealth University
2008-2014
Harbin Institute of Technology
2013-2014
Non‐Technical Summary The islet of Langerhans secretes the hormone insulin in response to elevated glucose. Interactions between cells within is important for regulation secretion, both suppress basal secretion and enhance glucose‐stimulated response. We show that multiple mechanisms cell–cell communication are required suppression release. First, gap junctions spontaneous calcium signals which suppresses triggering Second, other juxtacrine mechanisms, regulated by cAMP glucose, more distal...
Insulin is known to regulate pancreatic β-cell function through the activation of cell surface insulin receptors, phosphorylation receptor substrate (IRS)-1 and -2, phosphatidylinositol (PI) 3-kinase. However, an acute effect in modulating electrical activity its underlying ionic currents has not been reported. Using perforated patch clamp technique, we found that (1–600 nmol/l) but IGF-1 (100 reversibly hyperpolarized single mouse β-cells inhibited their activity. The dose-response...
Abstract Curcumin is a diketone compound extracted from the rhizomes of number plants in Zingiberaceae family and has wide range pharmacological activities. In order to improve its shortcomings such as poor stability low bioavailability, it often modified into monocarbonyl derivatives. present study, fluoro‐ hydroxy‐substituted curcumin derivatives (compounds 1a–1e 2a–2e) are systematically investigated through chemical calculations. Based on most stable geometry each substituent,...
Gas-phase acidities of polyfluorinated hydrocarbons have been determined by measuring proton-transfer equilibria and computing the free energies deprotonated carbanions corresponding neutrals.An excellent linear relationship between accumulated inductive effects fluorine atoms contained in a molecule was observed for perfluoroalkyl-substituted neopentanes, (R f 1 )(R 2 3 )CCH , bridgehead carbon acids where contribution negative hyperconjugation C β -F bond to stability conjugate anions is...
A highly diastereoselective approach towards the synthesis of quaternary center-containing cyclopentenes was developed. The tandem Michael/aldol/rearrangement processes occurred under mild reaction conditions.
Recent work suggests that insulin may exert both positive and negative feedback directly on pancreatic β-cells. To investigate the hypothesis modulates β-cell metabolism, mouse islets clusters were loaded with rhodamine 123 to dynamically monitor mitochondrial membrane potential (ΔΨm). Spontaneous oscillations in ΔΨm (period: 218 ± 26 s) observed 17 of 30 exposed 11.1 mmol/l glucose. Acute application (100 nmol/l) hyperpolarized ΔΨm, indicating a change activity. The ATP-sensitive K+ (KATP)...
Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation handling in remains incompletely understood. Gem, member the RGK (Rad/Gem/Kir) family regulates channel other cell types, and Gem over-expression inhibits release insulin-secreting Min6 cells. The aim this study was explore role secretion. We hypothesised may regulate thus affect glucose tolerance vivo.Gem-deficient...
An efficient method for the highly diastereoselective synthesis of chiral quaternary center-containing cyclopentenes via a cinchona alkaloid-derived thiosquaramide VIII-catalyzed tandem Michael-Henry reaction phenacylmalononitriles and nitroolefins was deleveloped. Meanwhile, up to 98% enantioselectivity observed. A mechanism involving thiosqaramide-catalyzed asymmetric Michael addition assisted E2 elimination proposed based on experimental data preliminary theoretical analysis (Hartree-Fock...
Chronic exposure of pancreatic beta-cells to high concentrations glucose impairs the insulin secretory response further stimulation. This phenomenon is referred as desensitization. It has been shown that desensitization associated with abnormal elevation beta-cell basal intracellular free Ca2+ concentration ([Ca2+]i). We have investigated relationship between and L-type (Cav1.3) channel translocation in insulin-secreting cells. Glucose stimulation or membrane depolarization induced a...