A5026126152- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Hernia repair and management
- Water Treatment and Disinfection
- Organoboron and organosilicon chemistry
- Fluorine in Organic Chemistry
- Pelvic and Acetabular Injuries
- Advanced Photocatalysis Techniques
- Click Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Environmental remediation with nanomaterials
- Nanomaterials for catalytic reactions
- Advanced oxidation water treatment
- Concrete and Cement Materials Research
- Asymmetric Synthesis and Catalysis
- HIV/AIDS drug development and treatment
- Polyoxometalates: Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Cyclopropane Reaction Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
Jiangsu University of Science and Technology
2019-2025
Huadong Hospital
2021-2025
Fudan University
2021-2025
Shandong University
2017-2025
Harbin Institute of Technology
2021-2023
Sichuan University of Science and Engineering
2023
Qingdao Agricultural University
2019-2022
Boston University
2013-2022
Changsha Mining and Metallurgy Research Institute (China)
2022
First Affiliated Hospital of Zhengzhou University
2021
A N2-bridged diiron complex [Cp*(Ph2PC6H4S)Fe]2(μ-N2) (1) has been found to catalyze the hydroboration of N-heteroarenes with pinacolborane, giving N-borylated 1,2-reduced products high regioselectivity. The catalysis is initiated by coordination iron center, while B–H bond cleavage rate-determining step.
Using a single half-sandwich iron(II) compound, Cp*Fe(1,2-Ph2PC6H4S)(NCMe) (Cp*– = C5Me5–, 1) as catalyst, reductive coupling of nitroarenes with olefins has been achieved by well-defined iron(II)/(EtO)3SiH system. Through either inter- or intramolecular coupling, various branched amines and indole derivatives have directly synthesized in one-pot. Mechanistic studies showed that the catalysis is initiated activation catalyst silane, generating iron–nitrosoarene intermediate for C–N bond coupling.
A general method for site-selective difluoroalkylation of alkyl carboxylic redox esters with difluoroenoxysilanes through photoredox-catalyzed decarboxylative reaction has been developed. The can also be extended to aliphatic amine derived pyridinium salts. This the advantages high efficiency, mild conditions, and broad substrate scope, including primary, secondary, sterically hindered tertiaryl substrates, providing a practical route applications in organic synthesis pharmaceutical studies.
Ergothioneine (5) and ovothiol (8) are two novel thiol-containing natural products. Their C–S bonds formed by oxidative coupling reactions catalyzed EgtB OvoA enzymes, respectively. In this work, it was discovered that in addition to catalyzing the between histidine cysteine (1 → 6 conversion), can also catalyze a direct hercynine (2) (2 4 which shorten ergothioneine biosynthetic pathway steps.
This paper describes a cooperative iron–thiolate catalyst Cp*Fe(1,2-Ph2PC6H4S)(NCMe) (Cp*– = C5Me5–, [1(NCMe)]) for regioselective hydroboration of aryl epoxide by pinacolborane (HBpin). The critical catalytic step involves the direct addition to rather than activation B–H bond HBpin. Through cooperation, [1(NCMe)] opens rings affording ferrous–alkoxide compounds. Notably, intermediate (4) was structurally characterized after its isolation from reaction with trans-2,3-diphenyloxirane. more...
The regio- and chemoselective construction of indole bearing an all-carbon center at the C3-position, a versatile bioactive building block, by C(sp2)–C(sp3) formation with olefins has been achieved through utilization hexafluoroisopropanol (HFIP) as protonation reagent solvent. catalytic reactions are operationally simple green compared previous reports utilizing elaborated catalysts. This protocol allows for alkylation variety substituted indoles diverse styrene type alkenes in excellent...
Highly toxic iodinated products would form in oxidation and disinfection of iodine-containing water. Variation aromatic ferrate [Fe(VI)] phenolic compounds (phenol, bisphenol A (BPA), p-hydroxybenzoic acid (p-HBA)) water was investigated. At pH 5.0, inhibited by competitive reaction with I-, no formation detected. Almost all I- converted into nontoxic IO3-. 7.0, 8.0, 9.0, HOI formed further reacted phenols, the products. Mass spectrometry analysis showed that both kinds contents were raised...
Microplastic pollution has aroused surging concerns, while methods for quantitively analyzing the removal of microplastic in water treatment are insufficient. Herein, a flow cytometry (FCM)-fluorescent beads (FB) method was developed evaluating micrometer-sized treatment. Commercial fluorescently labeled polystyrene (Φ = 3 μm) were spiked into to mimic microplastic, and FCM used quantitive determination. The coefficient determination (R2) amount microplastics detected signals pure water,...
The green synthesis of (hetero)aromatic amines is highly expected but challenging.
The installation of deuterium atoms at distal C(sp3)–H bonds is a longstanding synthetic challenge. Through the synergistic combination chain-walking strategy and transfer hydrodeuteration, we present remote hydrodeuteration unactivated alkenes sites, aided by native directing groups, using readily available pinacolborane (HBpin) D2O as H– D+ sources, respectively. Significantly, this tactic offers complementary pattern to conventional methods that adduct H–D, or its surrogate, unsaturated...
Abdominal wall defects caused by neoplasms with large extended resection remain a challenging problem. Autologous flaps, meshes, and component separation techniques are effective in reconstructing these defects. We retrospectively reviewed assessed the success of reconstruction using tensor fascia lata flap or without meshes. 18 patients abdominal were identified during period from 2007 to 2016. A retrospective review office charts hospital records was performed. total received corresponding...
Mononuclear non-heme iron enzymes are a large class of catalyzing wide-range reactions. In this work, we report that enzyme in Methyloversatilis thermotolerans, OvoAMtht, has two different activities, as thiol oxygenase and sulfoxide synthase. When cysteine is presented the only substrate, OvoAMtht oxygenase. presence both histidine substrates, catalyzes oxidative coupling between (a synthase). Additionally, demonstrate substrates active site iron's secondary coordination shell residues...
Reported herein is a novel p-quinone methide-based self-immobilizing fluorogenic probe for the visualization of β-galactosidase activities in live cells. This easily prepared imaging reagent massively increases fluorescence intensity and covalently links to activation site with high efficiency upon enzymatic trigger.
We report an iron system, Cp*Fe(1,2-R2PC6H4X), which controls the Markovnikov and anti-Markovnikov hydrostannation of alkynes by tuning ionic metal–heteroatom bonds (Fe–X) reactivity. The sequential addition nBu3SnH to iron–amido catalyst (1, X = HN–, R Ph) affords a distannyl Fe(IV)–H species responsible for syn-addition Sn–H bond across C≡C produce branched α-vinylstannanes. Activation C(sp)–H iron–aryloxide (2, O–, Cy) iron(II) vinylidene intermediate, allowing gem-addition...
Triggering C-N bond formation with nitroaromatics and boronic acids at mild conditions is highly desirable, since most prior works were carried out under harsh sometimes suffered from poor chemo- or regioselectivity. Herein, a low-valent-tungsten-catalyzed reaction that enables the ambient temperature amination of disclosed. With readily available W(CO)6 as precatalyst external-photosensitizer-free conditions, smoothly undergo coupling reactions their acid partners, delivering structurally...
Herein, we have developed an efficient tungsten-catalyzed homogeneous system for oxidative dehydrogenative coupling of anilines to selectively produce various azoaromatics and azoxyaromatics as well 2-substituted indolone N-oxides by simply regulating the reaction solvent with peroxide a terminal oxidant under additive-free conditions. These findings provide experimental framework exploring tungsten catalysis in organic synthesis offer convenient tactic selective oxidation anilines.
The incorporation of fluorine atoms in organics improves their bioactivity and lipophilicity. Catalytic functionalization gem-difluorodienes represents one the most straightforward approaches to access fluorinated alkenes. In contrast regular 1,3-dienes that undergo diverse asymmetric di/hydrofunctionalizations, regio- enantioselective oxyamination remains untouched. Herein, we report 1,4-oxyamination gem-difluorodiene by chiral rhodium-catalyzed three-component coupling with readily...
In the research presented herein, low-valent-tungsten-catalyzed hydroboration of esters and nitriles was investigated.