A5102840432- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Solar-Powered Water Purification Methods
- Synthesis and Properties of Aromatic Compounds
- RNA modifications and cancer
- Electrospun Nanofibers in Biomedical Applications
- Photochromic and Fluorescence Chemistry
- Bacteriophages and microbial interactions
- Biosensors and Analytical Detection
- Cell death mechanisms and regulation
- Telomeres, Telomerase, and Senescence
- Surface Modification and Superhydrophobicity
- Cytomegalovirus and herpesvirus research
- Advanced NMR Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- ZnO doping and properties
- Microbial Community Ecology and Physiology
- Single-cell and spatial transcriptomics
- Membrane Separation Technologies
- X-ray Diffraction in Crystallography
Collaborative Innovation Center of Chemistry for Energy Materials
2020-2024
Xiamen University
2020-2024
Abstract Despite widespread applications for cancer treatment, chemotherapy is restricted by several limitations, including low targeting specificity, acquired drug resistance, and concomitant adverse side effects. It remains challenging to overcome these drawbacks. Herein, we report a new bioenergetic approach treating efficiently. As proof‐of‐concept, construct activatable mitochondria‐targeting organoarsenic prodrugs from compounds traditional chemotherapeutics. These could accomplish...
Abstract Extracellular vesicles (EVs) have demonstrated unique advantages in serving as nanocarriers for drug delivery, yet the cargo encapsulation efficiency is far from expectation, especially hydrophilic chemotherapeutic drugs. Besides, intrinsic heterogeneity of EVs renders it difficult to evaluate behaviour. Inspired by active loading strategy liposomal nanomedicines, here we report development a method, named “Sonication and Extrusion‐assisted Active Loading” (SEAL), effective stable...
Herein, a nitrogen-embedded quintuple [7]helicene (N-Q7H) with an azapentabenzocorannulene core, which can be considered to helicene/azacorannulene hybrid π-system, was synthesized from in three-step process. N-Q7H is the first example of multiple helicene azabuckybowl core. Single-crystal X-ray diffractometry unambiguously confirmed structure propeller-shaped π-system. Owing nitrogen-atom doping helicenes and effective hybridization between azacorannulene, exhibits considerably redshifted...
Abstract Mitochondrial permeability transition (mPT)-mediated mitochondrial dysfunction plays a pivotal role in various human diseases. However, the intricate details of its mechanisms and sequence events remain elusive, primarily due to interference caused by Bax/Bak-induced outer membrane permeabilization (MOMP). To address these, we have developed methodology that utilizes nano-flow cytometry (nFCM) quantitatively analyze opening pore (mPTP), dissipation potential ( $$\Delta$$ <mml:math...
Correlated analysis of multiple biochemical parameters at the single-particle level and in a high-throughput manner is essential for insights into diversity functions biological nanoparticles (BNPs), such as bacteria subcellular organelles. To meet this challenge, we developed highly sensitive spectral nano-flow cytometer (S-nFCM) by integrating recording module to laboratory-built nFCM that 4–6 orders magnitude more side scattering detection 1–2 fluorescence than conventional flow...
Monitoring mitochondrial esterase activity is crucial not only for investigating metabolism but also assessing the effectiveness of mitochondrial-targeting prodrugs. However, accurately detecting within mitochondria poses challenges due to its ubiquitous presence in cells and uncontrolled localization fluorogenic probes. To overcome this hurdle reveal variations among different mitochondria, we isolated preserved their functionality a buffered environment. Subsequently, utilized...
A surface functionalization method was developed for enhanced cancer-targeting of EVs, where an nFCM-based methodology applied to reveal heterogeneity.
Abstract Despite widespread applications for cancer treatment, chemotherapy is restricted by several limitations, including low targeting specificity, acquired drug resistance, and concomitant adverse side effects. It remains challenging to overcome these drawbacks. Herein, we report a new bioenergetic approach treating efficiently. As proof‐of‐concept, construct activatable mitochondria‐targeting organoarsenic prodrugs from compounds traditional chemotherapeutics. These could accomplish...
Telomere length (TL) is a highly relevant biomarker for age-associated diseases and cancer, yet its clinical applications have been hindered by the inability of existing methods to rapidly measure TL distribution percentage chromosomes with critically short telomeres (CSTs, < 3 kb). Herein, we report development high-throughput method at single-chromosome level. Metaphase are isolated, hybridized Alexa Fluor 488-labeled telomeric peptide nucleic acid probe, analyzed using laboratory-built...
Objective To establish the method of fluorescence quantitative PCR for detection Cytomegalovirus （CMV） DNA from newborn dried blood spots (DBS) and evaluate limit (LOD), precision, specificity clinical application. Methods Primers probes were selected CMV-gB segment standard plasmids constructed to detect concentration CMV strains.The LOD, within-run between-run precisions obtained by 10-fold serial dilutions strains in DBS with PCR. This assay was further evaluated detecting 10...