Xiaofen Wu

ORCID: 0000-0002-4534-4638
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About
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Research Areas
  • Echinoderm biology and ecology
  • Cell death mechanisms and regulation
  • Cardiovascular Health and Disease Prevention
  • Cardiac electrophysiology and arrhythmias
  • Advanced Antenna and Metasurface Technologies
  • Phytochemicals and Antioxidant Activities
  • Immune Response and Inflammation
  • Electromagnetic wave absorption materials
  • Tea Polyphenols and Effects
  • Neurological Disease Mechanisms and Treatments
  • Prostate Cancer Diagnosis and Treatment
  • Macrophage Migration Inhibitory Factor
  • Cardiovascular Function and Risk Factors
  • Frailty in Older Adults
  • Radiomics and Machine Learning in Medical Imaging
  • AI in cancer detection
  • Blood Pressure and Hypertension Studies
  • Biofuel production and bioconversion
  • Education and Work Dynamics
  • Cancer-related molecular mechanisms research
  • Traumatic Brain Injury Research
  • Traditional Chinese Medicine Analysis
  • Genomics and Phylogenetic Studies
  • Heme Oxygenase-1 and Carbon Monoxide
  • Food Quality and Safety Studies

Second Affiliated Hospital of Soochow University
2025

Soochow University
2025

Tongji Hospital
2013-2024

Huazhong University of Science and Technology
2013-2024

Hunan Academy of Agricultural Sciences
2018-2024

University of Jinan
2023-2024

Shanxi Medical University
2021-2024

Lishui Central Hospital
2017-2024

South China Sea Institute Of Oceanology
2019-2023

Chinese Academy of Sciences
2019-2023

Considering the risk of a sudden degeneration caused by oxidation MXenes in dielectric and microwave absorption properties, to enhance resistance multilayer can make them more applicable as absorbers than those with few-layer. However, there remains disadvantage optimizing poor impedance matching inherent aggregation via rational assembling. In present study, facile self-assembly process is conducted obtain 2D MXenes/1D MnO2/0D NiCo2S4 assembled low-dimensional aggregate hierarchical...

10.1016/j.apmate.2022.100100 article EN cc-by Advanced Powder Materials 2022-12-29

Some tropical sea cucumbers of the family Holothuriidae can efficiently repel or even fatally ensnare predators by sacrificially ejecting a bioadhesive matrix termed Cuvierian organ (CO), so named French zoologist Georges Cuvier who first described it in 1831. Still, precise mechanisms for how adhesiveness genetically arose CO and perceive transduce danger signals expulsion during defense have remained unclear. Here, we report high-quality, chromosome-level genome assembly

10.1073/pnas.2213512120 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2023-04-10

Oocyte maturation and ovarian development are sequentially coordinated events critical to reproduction. In the ovaries of adult oviparous animals such as birds, bony fish, insects crustaceans, vitellogenin receptor (VgR) is a plasma membrane that specifically mediates (Vg) transport into oocytes. Accumulation Vg drives sexual female crustaceans by acting pivotal regulator nutritional accumulation within oocytes, process known vitellogenesis. However, mechanisms which VgR vitellogenesis still...

10.3389/fphys.2020.00485 article EN cc-by Frontiers in Physiology 2020-05-15

Endowing composites with defects such as oxygen vacancies is an easy and effective strategy to determine the physical chemical properties of nanomaterials. The influence on microwave absorption remains a very open question. Herein, MnO2/Ti3C2Tx MXene are self-assembled, demonstrating boosting through Ni doping in MnO2 modulate vacancies. Ni-doped (Ni–MnO2) nanorods diameters about 40 nm dispersed surface interlay MXene. As expected, reflection loss (RL) value bandwidth (EAB) Ni–MnO2/MXene...

10.1021/acsaelm.2c00654 article EN ACS Applied Electronic Materials 2022-06-30

Discriminatively visualizing mitochondrial and lysosomal dysfunction is crucial for an in-depth understanding of cell apoptosis regulation relative biology. However, fluorescent probes the separate visualization mitochondria damages have not been reported yet. Herein, we constructed a probe [2-(4-hydroxystyryl)-1,3,3-trimethyl-3H-indol-1-ium iodide (HBSI)] labeling lysosomes in dual emission colors discriminatively imaging damage two different sets signals. In living cells, HBSI targeted...

10.1021/acs.analchem.3c03024 article EN Analytical Chemistry 2023-09-19

White matter hyperintensity (WMH) and brain atrophy, as imaging marker of cerebral small-vessel diseases (CSVD), have a high prevalence strong prognostic value in stroke. We aimed to explore the association between lymphocyte count, maker inflammation, WMH atrophy patients with acute ischemic stroke (AIS). A total 727 AIS count magnetic resonance data were enrolled. Participants divided into four groups according quartiles baseline counts. is frequently periventricular (PVH) deep white...

10.3389/fnagi.2024.1492078 article EN cc-by Frontiers in Aging Neuroscience 2025-01-08

Background— Loss-of-function mutations in Na v 1.5 cause sodium channelopathies, including Brugada syndrome, dilated cardiomyopathy, and sick sinus syndrome; however, no effective therapy exists. MOG1 increases plasma membrane (PM) expression of current ( I ) density, thus we hypothesize that can serve as a therapeutic target for channelopathies. Methods Results— Knockdown using small interfering RNAs reduced PM expression, decreased densities by 2-fold HEK/Na cells nearly abolished mouse...

10.1161/circep.111.000206 article EN Circulation Arrhythmia and Electrophysiology 2013-02-19

Abstract Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, role of miRNAs OSCC development and progression not well understood. Methods We sought to establish dynamic Chinese hamster animal model, construct miRNA differential expression profiles its occurrence development, predict targets, perform functional analysis validation vitro. Results Using...

10.1186/s12885-023-10600-3 article EN cc-by BMC Cancer 2023-02-17

Humour is a powerful resource in medical education. The purpose of this study to investigate what students and teachers think about the use humour. What challenges do face using humour how they address them are also subject present study.Separate cross-sectional questionnaire surveys.Tongji Medical College Tongji Hospital China.327 at 165 physician China.The primary outcome was assessed by proportion.87% student teacher respondents agreed with didactic setting. They felt fostered positive...

10.1136/bmjopen-2017-018853 article EN cc-by-nc BMJ Open 2017-11-01

Abstract RIPK1 is a crucial regulator of cell death and survival. Ripk1 deficiency promotes mouse survival in the prenatal period while inhibits early postnatal without clear mechanism. Metabolism regulation autophagy are critical to neonatal from severe starvation at birth. However, mechanism by which regulates resistance remains unclear. Here, we address this question discovering metabolic regulatory role RIPK1. First, metabolomics analysis reveals that specifically increases aspartate...

10.1038/s41467-021-26423-4 article EN cc-by Nature Communications 2021-10-22

Solvatochromic fluorescent probes are crucial molecular tools to investigate and aggregate proteins' fold, visualize fine structures in biomembranes, label different organelles dual emission colors. However, solvatochromic fluorogens often displayed a weak at high polarity, hindering their bioimaging applications. To resolve this problem, herein, we propose an intramolecular charge transfer (ICT) inhibition strategy. The probe was designed with single electronic donor two acceptors order...

10.1021/acs.analchem.4c03559 article EN Analytical Chemistry 2024-10-18

This study aims to explore the value of a machine learning (ML) model based on radiomics features and clinical in predicting outcome spontaneous supratentorial intracerebral hemorrhage (sICH) 90 days after surgery. A total 348 patients with sICH underwent craniotomy evacuation hematoma from three medical centers. One hundred eight were extracted lesions baseline CT. Radiomics screened using 12 feature selection algorithms. Clinical included age, gender, admission Glasgow Coma Scale (GCS),...

10.3390/jcm12041580 article EN Journal of Clinical Medicine 2023-02-16

This study aimed to investigate the gene expression changes associated with carcinoma-associated fibroblasts (CAFs) involving in non-small cell lung carcinoma (NSCLC).We downloaded GEO series GSE22862, which contained matched values for 15 CAF and normal samples, GSE27289 containing SNP genotyping four NSCLC samples. The differentially expressed genes samples were identified using limma package R. Then we performed ontology (GO) pathway enrichment analysis protein-protein interaction (PPI)...

10.1186/s40659-017-0108-9 article EN cc-by Biological Research 2017-02-23

Abstract Background Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed identify most informative measures serum lipids their calculated ratios in terms stiffness risk. Methods Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density (HDL-C), brachial-ankle pulse wave velocity (baPWV) 659 healthy males (47.4 ± 10.7 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C...

10.1186/s12872-020-01846-x article EN cc-by BMC Cardiovascular Disorders 2021-01-13
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