A5056284145- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Dialysis and Renal Disease Management
- Ginseng Biological Effects and Applications
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Disease and Adiposity
- Parathyroid Disorders and Treatments
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
- Nutritional Studies and Diet
- Natural product bioactivities and synthesis
- Diabetes Treatment and Management
- Extracellular vesicles in disease
- Frailty in Older Adults
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Medicinal Plant Pharmacodynamics Research
- Body Composition Measurement Techniques
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Atherosclerosis and Cardiovascular Diseases
Sichuan University
2005-2025
Shanghai University of Traditional Chinese Medicine
2014-2025
Yueyang Hospital
2014-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
West China Medical Center of Sichuan University
2024
West China Hospital of Sichuan University
2005-2024
Sichuan Research Center of New Materials
2021-2022
Shanghai University
2014
Cleveland Clinic Lerner College of Medicine
2010-2011
Case Western Reserve University
2010-2011
Background Systemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation has been reported to be related with renal damage. We aimed investigate the possible relationship between SII albuminuria. Methods The present cross-sectional study was conducted among adults complete data about urinary albumin-to-creatinine ratio (ACR) in 2005–2018 National Health Nutrition Examination Survey (NHANES). calculated as platelet count × neutrophil count/lymphocyte count....
The negative effect of obesity on kidney health has been reported. association between weight-adjusted-waist index (WWI, a newly developed adiposity index) and albuminuria not reported earlier.This cross-sectional study was conducted among adults with complete data about WWI urinary albumin-to-creatinine ratio (ACR) in 2005-2018 National Health Nutrition Examination Survey (NHANES). calculated as waist circumference (WC) divided by the square root weight. Weighted multivariable logistic...
Abstract The negative effects of obesity on the cardiovascular health have drawn much attention. Weight-adjusted-waist index (WWI) has been proved to reflect weight-independent centripetal obesity. However, association between WWI and abdominal aortic calcification (AAC) not reported before. Using data from National Health Nutrition Examination Survey 2013–2014, we aimed determine relationship AAC in adults aged ≥ 40 years. was determined by dividing waist circumference square root weight....
Abstract Metastasis remains a major cause of mortality and poor prognosis in breast cancer patients. Anti-metastatic therapies are great need to achieve optimal clinical outcome Panax Notoginseng Saponins (PNS) has previously been shown inhibit metastasis mouse. Here the potential anti-metastatic effect one chemical compounds PNS, ginsenoside Rd (Rd), was further evaluated mouse mammary carcinoma 4T1 cells. The results revealed that treatment dose-dependently suppressed cell migration...
Aims Atherosclerosis is the primary cause of cardiovascular diseases and stroke. The current study evaluated interventional effects a naturally occurring compound Notoginsenoside R1 (NR1) on atherosclerosis in ApoE−/− mice. Methods Results atherosclerotic lesion was significantly alleviated by NR1 treatment this attenuation marked reduction lipid deposition, fibrosis oxidative stress. Increased serum levels GSH SOD decreased level MDH were observed NR1-treated also CHO, TG, ox-LDL increased...
The negative effects of visceral adiposity accumulation on cardiovascular health have drawn much attention. However, the association between Visceral Adiposity Index (VAI) and Abdominal Aortic Calcification (AAC) has never been reported before. authors aimed to investigate VAI AAC in US adults.Cross-sectional data were derived from 2013 2014 National Health Nutrition Examination Survey (NHANES) participants with complete scores. Weighted multivariable regression logistic analysis conducted...
Background Under hyperglycemic conditions, impaired intestinal barrier integrity leads to heightened level of inflammation, playing important roles in driving diabetic complications. Emerging evidence supports the implications neutrophil extracellular traps (NETs) pathogenesis diabetes. However, whether NETs contribute hyperglycemia-linked impairment remains be investigated. Moreover, baicalin, major chemical component Scutellaria baicalensis Georgi, is equipped with twofold protective and...
Abstract Objective: We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22‐24 ( RLS3 ) and later genome‐wide association study (GWAS) implicated the PTPRD gene at l ocus as susceptibility RLS. However, from standpoint of genetics, GWAS needs be validated by independent studies. In this study, we used both family‐based population‐based studies assess between RLS in an American Caucasian population. Methods: genotyped two intronic SNPs rs1975197 rs4626664 144...
purpose. A four-generation Chinese family with 13 members affected autosomal dominant congenital posterior polar cataract was studied. The purpose of this study to identify the disease-causing gene in and validate that mutations CRYAB, αB-crystallin gene, cause cataract. methods. Linkage analysis performed a panel microsatellite markers flanking candidate genetic loci for cataracts, including 14 known (ADCC) genes. For mutation analysis, complete coding region exon-intron boundaries CRYAB...
(1) Background: Preclinical and clinical studies on the anti-aging effect of α-Klotho are emerging. Urinary albumin excretion (UAE) is a well-known biomarker kidney injury generalized damage in cardiovascular system. However, potential relationship between UAE limited controversial. This study aimed to quantify this general middle-aged elderly population from National Health Nutrition Survey (NHANES) 2007-2016. (2) Methods: Serum was measured by enzyme-linked immunosorbent assay. assessed...
We investigated the relationship between low lean mass (LLM) and lower urinary tract symptoms (LUTS) using 2005â2006 National Health Nutrition Examination Survey (NHANES) dataset. enrolled 959 men with an average age of 52.08 ± 7.91 years performed weighted multiple regression analysis to determine independent exposure variables (LLM, alternate LLM) outcomes (urinary hesitancy, incomplete emptying, frequency, nocturia, daytime LUTS, clinical LUTS) after adjusting for confounding factors....
Aims: We aimed to assess the association between dietary inflammation index (DII) and abdominal aortic calcification (AAC) in US adults aged ≥40 years. Methods: Data were obtained from 2013–2014 National Health Nutrition Examination Survey (NHANES). Participants who <40 years old missing data of DII AAC excluded. was calculated based on a 24-h recall interview for each participant. score quantified by assessing lateral spine images severe defined as >6. Weighted multivariable...