A5027064196- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Cancer-related molecular mechanisms research
- Thermal and Kinetic Analysis
- Circular RNAs in diseases
- Energetic Materials and Combustion
- Advanced Decision-Making Techniques
- Topic Modeling
- Lung Cancer Treatments and Mutations
- Natural Language Processing Techniques
- RNA Research and Splicing
- Text and Document Classification Technologies
- Chemical Thermodynamics and Molecular Structure
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Sports Analytics and Performance
- Ideological and Political Education
- AI and Big Data Applications
- Rough Sets and Fuzzy Logic
- Educational Technology and Pedagogy
- Applied Advanced Technologies
- Nanoplatforms for cancer theranostics
- Cancer and Skin Lesions
- Fibroblast Growth Factor Research
Nanjing University of Science and Technology
2024
Jiangxi University of Science and Technology
2008-2023
University of Science and Technology
2023
Yantaishan Hospital
2000-2022
National Center for Toxicological Research
2012-2022
Tsinghua University
2022
United States Food and Drug Administration
2012-2019
North China Electric Power University
2019
Qingdao University
2018
Center for Drug Evaluation and Research
2016
Abstract Background Animals exposed to sevoflurane during development sustain neuronal cell death in their developing brains. In vivo micro-positron emission tomography (PET)/computed imaging has been utilized as a minimally invasive method detect anesthetic-induced adverse effects animal studies. Methods Neonatal rhesus monkeys (postnatal day 5 or 6, 3 6 per group) were for 8 h 2.5% with without acetyl-l-carnitine (ALC). Control room air ALC. Physiologic status was monitored throughout...
Shuliang Liu, Xuming Hu, Chenwei Zhang, Shu'ang Li, Lijie Wen, Philip Yu. Proceedings of the 2022 Conference North American Chapter Association for Computational Linguistics: Human Language Technologies. 2022.
Background . The inhalation anesthetics nitrous oxide (N 2 O) and isoflurane (ISO) are used in surgical procedures for human infants. Injury to the central nervous system is often accompanied by localization of activated microglia or astrocytosis at site injury. tracer that targets peripheral benzodiazepine receptor (PBR), [ 18 F]N-2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([ F]-FEPPA), has been reported as a sensitive biomarker detection neuronal damage/inflammation....
Aim: To evaluate intravenously injected bovine serum albumin-templated gold nanoparticles (BSA-GNPs) for radiosensitization effects on H22 hepatoma-bearing mice. Materials & methods: BSA-GNPs in different size were with a dose of 4 mg Au/kg. After 30 min injection, the tumor-bearing mice irradiated 5 Gy x-ray. Results: 8, 50 and 187 nm synthesized have no obvious cytotoxicity to HeLa, HepG2 HeCat cells when concentration was up 32 μM. And physiological injury occurred intravenous injection...
The aim of the study was to examine drug resistance analysis gefitinib-targeted therapy in non-small cell lung cancer (NSCLC). In total, 156 NSCLC patients without surgical treatment were selected, including 117 cases adenocarcinoma (75%), receive single gefitinib 0.25 g/day or combined with platinum chemotherapy. Computed tomography used evaluate tumor growth for response and non-response groups. chemotherapy regimen changed radiotherapy group. Tumor progression metastasis group considered...
General anesthetic-induced apoptotic neurodegeneration confirmed in animal models caused substantial concerns over the safety of pediatric patients undergoing general anesthesia. Therefore, studies search translational molecular probes for labeling neurons are imperative. The purpose current study is to examine utility [18F]-DFNSH as an apoptosis probe positron emission tomography (PET) evaluating sevofluraneinduced neuronal developing rat brain. Neonatal rats were exposed 2.5% sevoflurane...
Neural progenitor cell expansion is critical for normal brain development and an appropriate response to injury. During the growth spurt, exposures general anesthetics, which either block N-methyl-d-aspartate receptor or enhance γ-aminobutyric acid type A can disturb neuronal transduction. This effect be detrimental development. Until now, effects of anesthetic exposure on neural in vivo had seldom been reported. Here, minimally invasive micro positron emission tomography (microPET) coupled...
Purpose: Cervical cancer (CC) is the fourth most common with high death rate in females. The study aims to detect mechanism of long non-coding RNA (LncRNA) PCAT1 on radiosensitivity CC. Methods: expression PCAT1, miR-128 and GOLM1 CC tissues cells was measured by qRT-PCR. Different doses X-ray were used for radiation treatment 6 Gy chosen perform following experiments. proliferation, migration invasion MTT assay, wound healing assay transwell respectively. target relationships among...
Chemotherapy is one of the main treatment approaches for lung cancer. However, few drugs can be used in post-first-line Apatinib a small molecule inhibitor vascular endothelial growth factor receptor-2 (VEGFR-2) and widely advanced gastric This study aimed to investigate therapeutic effect apatinib second-line cancer explore its underlying mechanism from aspect macrophage-mediated epithelial-mesenchymal transition (EMT). The results showed that attenuated macrophage-induced EMT migration...
Lung cancer is one of the most common type cancers and leading cause cancer‑related mortality worldwide. Non-small cell lung (NSCLC) accounts for >80% cases. Emerging studies have suggested that microRNAs are dysregulated in NSCLC serve important roles initiation development. However, to best our knowledge, expression, molecular mechanism microRNA‑454 (miR‑454) not been investigated NSCLC. In present study, miR‑454 was demonstrated be significantly downregulated tissues lines, as assessed by...
Anesthetics have been used for years in pediatric patients without clinical evidence of adverse central nervous system (CNS) sequelae. In the current study, postnatal day (PND) 5–6 rhesus monkeys were exposed to nitrous oxide (N_2O; 70%) alone, isoflurane (ISO; 1.0%) or N_2O plus ISO 8 h. Six hours after completion anesthetic administration, neuronal toxicity was examined using histochemical and molecular imaging approaches. Histochemical data demonstrated that exposure developing monkey...
Multi-scenario route ranking (MSRR) is crucial in many industrial mapping systems. However, the community mainly adopts interactive interfaces to encourage users select pre-defined scenarios, which may hinder downstream performance. In addition, academic community, multi-scenario works only come from other fields, and there are no specifically focusing on data due lacking a publicly available MSRR dataset. Moreover, all existing still fail address three specific challenges of simultaneously,...
Abstract π-Stacking is common in materials, but different π–π stacking modes remarkably affect the properties and performances of materials. In particular, weak interactions, π-stacking hydrogen bonding often have a significant impact on stability sensitivity high-energetic compounds. A fused [5,7,5]-tricyclic energetic compound with conjugated structure has been designed synthesized. 4H-[1,2,5]Oxadiazolo[3,4-e][1,2,4]triazolo[3,4-g][1,2,4]triazepin-8-amine obtained 48% yield from...
At present, lung cancer ranks the first cause of tumor death in world, and malignant tumors SPN detected by imaging account for 5-40%, most which are peripheral cancer. The recovery solitary nodules after treatment has also been paid attention to. In order to explore correlation pulmonary nodule (SPN) with microvessel density (MVD), vascular parameters, ratio under virtual reality images smart medical evaluate differentiation ddPCR image observation diagnosis value, this article collects...
College English teaching focuses on course knowledge and grade examination, with a serious shortage of humanistic education, whereas general education focusing spirit can just make up for its deficiency. In order to improve the educational goal personality accomplishment, by understanding relationship between college teaching, problems in are found out direction measures reform put forward. With as guide, curriculum system is improved, scientific examination evaluation systems constructed,...