A5049846577- Kruppel-like factors research
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Protein Kinase Regulation and GTPase Signaling
- Genetic Syndromes and Imprinting
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- ATP Synthase and ATPases Research
- Caveolin-1 and cellular processes
- Aortic aneurysm repair treatments
- Cholesterol and Lipid Metabolism
- PARP inhibition in cancer therapy
- Macrophage Migration Inhibitory Factor
Hebei Medical University
2010-2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
Shandong First Medical University
2024
Hunan Normal University
2010-2024
Ministry of Education of the People's Republic of China
2010-2023
Fourth Hospital of Hebei Medical University
2023
Chongqing University
2021-2022
Qingdao University
2013-2022
Qingdao Municipal Hospital
2022
NF-κB-mediated inflammatory phenotypic switching of vascular smooth muscle cells (VSMCs) plays a central role in atherosclerosis and neointimal formation. However, little is known about the roles circRNAs regulation NF-κB signaling. Here, we identify involvement circ-Sirt1 that was one transcripts SIRT1 host gene VSMC response hyperplasia. First, cytoplasm, directly interacts with sequesters p65 from nuclear translocation induced by TNF-α sequence-dependent manner. The inhibitory complex...
The let-60 ras gene of Caenorhabditis elegans is one the key players in a signal transduction pathway that controls choice between vulval and epidermal differentiation response to extracellular signals. To identify components acting downstream signaling pathway, we have identified reduction-of-function mutation sur-1 completely suppresses multivulva phenotype hyperactive mutation. About 10% animals homozygous for also display specific intriguing cell lineage defect. In addition, results...
Phenotypic change of vascular smooth muscle cells (VSMCs) from a differentiated to dedifferentiated state accompanies the early stage atherosclerosis and restenosis. Although much progress has been made in determining molecular mechanisms involved VSMC dedifferentiation, research on redifferentiation is hindered by lack an appropriate complete model. We established vitro model using postconfluent VSMCs human umbilical artery. demonstrated that serum-deprived are capable redifferentiation....
Notch signaling pathway has been shown to play essential roles in T lymphocyte development. Activation of requires a sequential proteolytic cleavage, which converts from the full-length membrane-bound form transcriptionally active intracellular fragment. Studies Drosophila showed that Kuzbanian (Kuz) is responsible for enzymatic cleavage extracellular S2 site upon binding its ligand Delta. Both disintegrin and metalloprotease (ADAM) 10 ADAM17, members ADAM family metalloproteases, have...
Vascular smooth muscle cells (VSMCs) can transdifferentiate into macrophage-like in the context of sustained inflammatory injury, which drives vascular hyperplasia and atherosclerotic complications. Using single-cell RNA sequencing, we identify that VSMCs are key cell population mouse neointimal hyperplasia. Sex-determining region Y (SRY)-related HMG-box gene 10 (Sox10) upregulation is associated with VSMC accumulation pyroptosis vitro mice. Tumor necrosis factor α (TNF-α)-induced Sox10...
BACKGROUND Circular RNA (circRNA) is a special long-chain non-coding produced during the process of intracellular splicing. Also, circZNF609 abundant in human tissues, with multiple functions diseases, but its role colorectal cancer remains unknown. This study aimed to evaluate expression tumor tissue and serum samples from patients cell lines. MATERIAL AND METHODS The was measured by quantitative polymerase chain reaction (q-PCR) 45 paired 46 healthy controls, normal line, FHC, lines,...
Krüppel-like factor 4 (KLF4) is involved in phenotypic modulation of vascular smooth muscle cells (VSMCs). All-trans retinoic acid (ATRA) inhibits VSMC proliferation and induces differentiation. However, the role KLF4 ATRA-elicited remains unclear. Here, we show that treatment VSMCs with ATRA resulted significant inhibition migration VSMCs, as well up-regulation differentiation marker genes SM22α SM α-actin (α-SMA). At same time, target gene p53 was up-regulated, while dedifferentiation...
AimsKrüppel-like factor 4 (KLF4) is implicated in all-trans retinoic acid (ATRA)-induced and platelet-derived growth factor-BB (PDGF-BB)-repressed SM22α expression vascular smooth muscle cells (VSMCs). However, its exact mechanism of action remains unclear. We determined how KLF4 plays different roles ATRA- PDGF-BB-dependent regulation the gene.
MINT‐7013243: Klf5 (uniprotkb:Q66HP1) physically interacts (MI:0218) with RAR alpha (uniprotkb:Q9QWJ1) by anti bait coimmunoprecipitation (MI:0006)
BACKGROUND:Circular RNAs (circRNAs) are involved in the growth of many tumors. However, expression and possible role circ_cse1l (hsa_circ_0060745) colorectal cancer (CRC) unclear. The present study was designed to explore CRC. MATERIAL AND METHODS:The levels tissues serum samples 50 patients with CRC control subjects were analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). CCK-8, colony formation, transwell wound healing assays performed assess functions cell...