A5100380936- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Gastric Cancer Management and Outcomes
- Kruppel-like factors research
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Metastasis and carcinoma case studies
- Pulmonary Hypertension Research and Treatments
- Sodium Intake and Health
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Heat shock proteins research
- Urological Disorders and Treatments
- Connexins and lens biology
- Cancer-related gene regulation
- Circular RNAs in diseases
- Nutritional Studies and Diet
- Endoplasmic Reticulum Stress and Disease
- Hemoglobinopathies and Related Disorders
- Sperm and Testicular Function
Zhongnan Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
Northeast Agricultural University
2024
Shanghai Institute of Hypertension
2014-2023
Hebei Medical University
2012-2023
The First Affiliated Hospital, Sun Yat-sen University
2009-2023
Sun Yat-sen University
2009-2023
Peking University People's Hospital
2023
Peking University
2023
Weatherford College
2023
Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes macrophages, we investigated significance pathogenesis AAD its clinical relevance.
p53, circRNAs and miRNAs are important components of the regulatory network that activates EMT program in cancer metastasis. In prostate (PCa), however, it has not been investigated whether how p53 regulates by miRNAs. Here we show a Amotl1-derived circRNA, termed circAMOTL1L, is downregulated human PCa, decreased circAMOTL1L facilitates PCa cell migration invasion through downregulating E-cadherin upregulating vimentin, thus leading to progression. Mechanistically, demonstrate serves as...
Rationale: Neuregulin-1 (NRG-1) includes an extracellular epidermal growth factor–like domain and intracellular (NRG-1-ICD). In response to transforming factor-β1, its cleavage by proteolytic enzymes releases a bioactive fragment, which suppresses the vascular smooth muscle cell (VSMC) proliferation activating ErbB (erythroblastic leukemia viral oncogene homolog) receptor. However, NRG-1-ICD function in VSMCs remains unknown. Objective: Here, we characterize of underlying mechanisms VSMCs....
Inflammation-based indexes have been used to predict survival and recurrence in cancer patients. Systemic immune-inflammation index (SII) was reported be associated with prognosis some malignant tumors. In the present study, we aimed explore association between SII of patients gastric cancer.We retrospectively analyzed data from 444 who underwent gastrectomy at First Affiliated Hospital Sun Yat-sen University January 1994 December 2005. Preoperative calculated. The Chi square test or...
Benign prostatic hyperplasia (BPH) is a prevalent disorder in aging males. It investigated whether heat shock protein family A member 1A (HSPA1A), cytoprotective chaperone induced under stress, has been implicated the development of BPH. RNA-sequencing and single-cell sequencing analyses revealed significant upregulation HSPA1A BPH compared to controls. In vitro experiments elucidated that was localized epithelium stroma, with upregulated expression tissues. Moreover, silencing augmented...
Gene therapy approaches using recombinant adeno-associated virus serotype 2 (rAAV2) and 8 (rAAV8) have achieved significant clinical benefits. The generation of rAAV Reference Standard Materials (RSM) is key to providing points reference for particle titer, vector genome infectious titer gene transfer vectors. Following the example rAAV2RSM, here we generated characterized a novel RSM based on 8. rAAV8RSM was produced transient transfection, purification density gradient ultracentrifugation....
Background and objectives: The SBP values to be achieved by antihypertensive therapy in order maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether patients with a previous event, the optimal lower than low-to-moderate risk hypertensive patients, or more cautious blood pressure (BP) should obtained. Because uncertainty ‘the better’ ‘J-curve’ hypothesis correct, European Society Hypertension Chinese League have promoted randomized trial comparing treatment...
Pancreatic cancer has a poor prognosis. It is reported that the PI3K/Akt pathway activated in many cancers, and inhibition of can induce cell apoptosis most cancers. Polo-like kinase 1 (Plk1) also overexpressed malignancies, it controls multiple aspects mitosis apoptosis. Previous studies identified PI3K/Akt-dependent phosphorylation Plk1-Ser99 required for metaphase-anaphase transition. In this study, we aimed to investigate molecular mechanism regulating proliferation pancreatic lines...
Fine-resolution differentiation trajectories of adult human hematopoietic stem cells (HSCs) involved in the generation red is critical for understanding dynamic developmental changes that accompany erythropoiesis. Using single-cell RNA sequencing (scRNA-seq) primary terminal erythroid (CD34 − CD235a + ) isolated directly from bone marrow (BM) and umbilical cord blood (UCB), we documented transcriptome terminally differentiated erythroblasts at unprecedented resolution. The insights enabled...
Abstract Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant phenotypic alterations in smooth muscle cells (VSMCs). Gasdermin D (GSDMD) pore‐forming effector of pyroptosis. In this study, the role VSMC‐specific GSDMD alteration VSMCs and AAA formation determined. Single‐cell transcriptome analyses reveal Gsdmd upregulation angiotensin (Ang) II‐induced AAA. deletion ameliorates Ang apolipoprotein E (ApoE) −/− mice. Using untargeted metabolomic analysis, it...
Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expressed genes BPH identified by transcriptome sequencing 5 hyperplastic normal prostate specimens, which had not been elucidated prostate. This study aimed to ascertain mechanism GPX3 involved proliferation, apoptosis, autophagy ferroptosis BPH.Human tissues, silencing overexpression...
Increased blood pressure and high dietary salt are leading risks for death disability globally. Reducing the burden of both health United Nations' targets reducing noncommunicable disease. Nongovernmental organizations individuals can assist by ensuring widespread dissemination best available facts recommended interventions risks. Simple but impactful fact sheets be useful informing public, healthcare professionals, policy makers. The World Hypertension League has developed on hypertension...
Hyperphosphorylation and dysregulation of exon 10 splicing Tau are pivotally involved in pathogenesis Alzheimer disease (AD) and/or other tauopathies. Alternative 10, which encodes the second microtubule-binding repeat, generates isoforms containing three four repeats, termed 3R-Taus 4R-Taus, respectively. Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) lies at Down syndrome critical region chromosome 21. Overexpression this may contribute to early pathology via...
Transcriptional activation by transcription factors is coupled with histone acetylation and chromatin remodeling. However, the relationship between TGF-β1-induced gene Krüppel-like factor (KLF)-4 remains unknown. In our study, KLF4 overexpression or knockdown, respectively increased decreased H3 p300 occupancy, which concentrated in region containing TGF-β1 control elements (TCEs) of genes regulation during vascular smooth muscle cell (VSMC) differentiation. Coimmunoprecipitation glutathione...