A5101650235- Circular RNAs in diseases
- Effects of Radiation Exposure
- MicroRNA in disease regulation
- Radiation Therapy and Dosimetry
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Advanced Radiotherapy Techniques
- Ocular Oncology and Treatments
- Liver Disease Diagnosis and Treatment
- Hydrogen's biological and therapeutic effects
- Surgical Sutures and Adhesives
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Advances in Oncology and Radiotherapy
- Nanoplatforms for cancer theranostics
- Fatigue and fracture mechanics
- Biochemical effects in animals
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Hydrogels: synthesis, properties, applications
- Folate and B Vitamins Research
- Cancer Research and Treatments
Sichuan University
2023-2025
West China Hospital of Sichuan University
2023-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Shanghai Jiao Tong University
2024
Lanzhou University
2019-2023
First Hospital of Lanzhou University
2020-2022
Hebei Medical University
2017-2018
Second Hospital of Hebei Medical University
2017
University of Leicester
2017
University of South China
2016
Rationale: Neuregulin-1 (NRG-1) includes an extracellular epidermal growth factor–like domain and intracellular (NRG-1-ICD). In response to transforming factor-β1, its cleavage by proteolytic enzymes releases a bioactive fragment, which suppresses the vascular smooth muscle cell (VSMC) proliferation activating ErbB (erythroblastic leukemia viral oncogene homolog) receptor. However, NRG-1-ICD function in VSMCs remains unknown. Objective: Here, we characterize of underlying mechanisms VSMCs....
Surgical operations are the preferred treatment for gastric perforation (GP) but incur postoperative complications such as gastrointestinal adhesions and bacterial infections, leading to inefficient wound healing serious that may even threaten life of patient. Developing hydrogel dressings capable adapting environment (acid) decreasing visceral infections after GP is crucial. In this article, we developed an injectable, self-healing using cation–π interactions between protonated amines...
Abstract Background The lncRNA H19 is believed to act as an oncogene in various types of tumors and considered be a therapeutic target diagnostic marker. However, the role regulating radiosensitivity non-small cell lung cancer (NSCLC) cells unknown. Methods expression profiles lncRNAs NSCLC were explored via transcriptome sequencing. CCK-8, EdU incorporation clonogenic survival assays conducted evaluate proliferation cells. Flow cytometry Western blotting measure level apoptosis. binding...
Mass spectrometry imaging (MSI) has emerged as a revolutionary analytical strategy in biomedical research for molecular visualization. By linking the characterization of functional metabolites with tissue architecture, it is now possible to reveal unknown biological functions tissues. However, due complexity and high dimensionality MSI data, mining bioinformatics-related peaks from batch data sets achieving complete spatially resolved metabolomics analysis remain great challenge. Here, we...
This work was aimed at exploring the regulatory network of non-coding RNA (ncRNA) especially circular (circRNA) and microRNA (miRNA), in sensitivity non-small cell lung cancer (NSCLC) cells to low linear energy transfer (LET) X-ray high-LET carbon ion irradiations.The radioresistant NSCLC line A549-R11 obtained from its parental A549 through irradiation with X-rays 2.0 Gy per fraction for 30 times. The sensitivities A549, H1299 exposed ions were verified using colony formation assay. A...
Background: Radiation is a mode of treatment for many pelvic malignancies, most which originate in the gynecologic, gastrointestinal, and genitourinary systems. However, healthy gut unavoidably included irradiation volume, resulting undesirable results that manifest as radiation-induced diarrhea (RID), common side effect radiation therapy significantly affects patients' quality life. This study aimed to investigate potential mechanism after radiotherapy rats based on bile acid homeostasis...
To analyze the effect of carbon ion (12C6+) radiation may induce bystander on A549 cell metastasis and metabonomics.A549 was irradiated with to establish clone survival model transwell matrix assay applied measure viability, migration, invasion, respectively. Normal human embryonic lung fibroblasts (WI-38) were ions 0 2 Gy then transferred co-culture medium for 24 h. The migration invasion cells detected by Transwell chamber. analysis metabonomic information in transfer liquid phase mass...
<title>Abstract</title> Myocardial infarction (MI), a common and severe disease threatening human health worldwide, results from ischemic hypoxic-induced necrosis of cardiac tissue due to coronary artery obstruction or rupture. Hydrogen sulfide (H<sub>2</sub>S) is gasotransmitter involved in various physiological pathological processes. Exogenous supplementation H<sub>2</sub>S significantly beneficial for the treatment MI. In this study, novel donor - zinc nanoparticles encapsulated...
Abstract Objective Carbon ions suppress the effect of glutathione peroxidase 4 (GPX4) on proliferation and metastasis lung adenocarcinoma A549 cells. Methods The clonogenic formation ability cells was calculated with different ray doses radiation. Cell proliferation, cycle, apoptosis after irradiation were detected by cck8 flow cytometry. transwell assay used to detect cell migration invasion rays radiation GPX4 matrix metalloproteinase 2 E‐cadherin expression levels assessed...
The IL-17A/IL-17RA pathway plays an important regulatory role in immunity, but has not been studied atrial fibrillation. present study investigated the expression of myocardial fibrosis patients with AF. left appendage tissue and peripheral venous blood were collected. Primary fibroblasts cultured IL-17A intervention. ratio Th17 cells was detected using flow cytometry, concentrations serum inflammatory measured ELISA. Western blotting used to evaluate signalling pathway. AF group higher than...
Abstract Background: LncRNA H19 was believed to act as an oncogene in various types of tumors and considered be a therapeutic target diagnosis marker. However, the role lncRNA regulating radiosensitivity non-small cell lung cancer (NSCLC) cells unknown. effects on NSCLC were not clear. Methods: The expression profiles lncRNAs explored via transcriptome sequencing NSCLC. CCK-8, EDU, clonogenicity survival assay conducted explore proliferation cells. Results: Expression patterns revealed that...