A5005269313- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Connexins and lens biology
- Heat shock proteins research
- Urinary Bladder and Prostate Research
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Cholesterol and Lipid Metabolism
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Renal and related cancers
- Pelvic and Acetabular Injuries
- Bone health and treatments
- Epigenetics and DNA Methylation
- Lipid Membrane Structure and Behavior
- Phytoestrogen effects and research
- Fatty Acid Research and Health
- Sphingolipid Metabolism and Signaling
- Immunotherapy and Immune Responses
- Protein Interaction Studies and Fluorescence Analysis
- Hormonal Regulation and Hypertension
- Kruppel-like factors research
- Endoplasmic Reticulum Stress and Disease
- TGF-β signaling in diseases
Zhongnan Hospital of Wuhan University
2021-2025
Wuhan University
2021-2025
Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expressed genes BPH identified by transcriptome sequencing 5 hyperplastic normal prostate specimens, which had not been elucidated prostate. This study aimed to ascertain mechanism GPX3 involved proliferation, apoptosis, autophagy ferroptosis BPH.Human tissues, silencing overexpression...
Benign prostatic hyperplasia (BPH) is a prevalent disorder in aging males. It investigated whether heat shock protein family A member 1A (HSPA1A), cytoprotective chaperone induced under stress, has been implicated the development of BPH. RNA-sequencing and single-cell sequencing analyses revealed significant upregulation HSPA1A BPH compared to controls. In vitro experiments elucidated that was localized epithelium stroma, with upregulated expression tissues. Moreover, silencing augmented...
Background and objects Benign prostatic hyperplasia (BPH) is a common disease that impairs the life quality of elderly men. The close relationship BPH diabetes has been generally established, however, exact molecular mechanism remains unclear. Midline-1 (MID1) an E3 ubiquitin ligase belonging to Tripartite Motif family its involvement in initiation progression many diseases, such as diabetic kidney well accepted. This study aims illuminate potential impact high glucose (HG) on cells...
Abstract Benign prostatic hyperplasia (BPH) is a chronic condition which mainly affects elderly males. Existing scientific evidences have not completely revealed the pathogenesis of BPH. Glucose-regulated protein 78 (GRP78) member heat shock 70 superfamily, serves as an important regulator in many diseases. This study aims at elucidating role GRP78 BPH process. Human prostate tissues, cultured human cell lines (BPH-1 and WPMY-1) clinical data from patients were utilized. The expression...
Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the male urinary system, with its molecular mechanisms of pathogenesis remaining unclear. Y-27632, non-isoform-selective Rho kinase inhibitor, has shown therapeutic potential in various diseases but effects on static factors and fibrosis BPH remain unexplored. This study investigated human prostate tissues, cell lines, rat model using immunofluorescence, flow cytometry, quantitative reverse transcription polymerase chain...
Benign prostatic hyperplasia (BPH) is a common disease in elderly men with an uncertain etiology and mechanistic basis. Metabolic syndrome (MetS) also very illness closely related to BPH. Simvastatin (SV) one of the widely used statins for MetS. Peroxisome-proliferator-activated receptor gamma (PPARγ), crosstalking WNT/β-catenin pathway, plays important roles Our current study aimed examine SV-PPARγ-WNT/β-catenin signaling development Human prostate tissues cell lines plus BPH rat model were...
The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis. RhoA BPH remains unclear.This study aimed to clarify the expression, functional activity mechanism BPH. Human prostate tissues, human lines, rat model were used. Cell models knockdown overexpression generated. Immunofluorescence staining, quantitative real time PCR (qRT-PCR), Western blotting,...
Abstract Background Benign prostatic hyperplasia (BPH) is one of the most common illnesses in aging men. Recent studies found that bone morphogenetic protein 5 (BMP5) upregulated BPH tissues, however, role BMP5 development has not been examined. The current study aims to elucidate potential roles and related signaling pathways BPH. Methods Human prostate cell lines (BPH‐1, WPMY‐1) human/rat hyperplastic tissues were utilized. Western blot, quantitative real‐time polymerase chain reaction,...
Clear cell renal carcinoma (ccRCC) is the most common type of kidney tumor worldwide. Analysis The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases showed that immune-related gene (IRG) hematopoietic signal transducer (HCST) could provide guidance for diagnosis, prognosis, treatment ccRCC. RNA-seq data ccRCC tissues were extracted from two databases: TCGA ( https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga ) GEO...
C-X-C motif chemokine ligand 13 (CXCL13), a member of the CXC subtype in superfamily, affects numerous biological processes various types cells and progress great number clinical diseases. The purpose current study was to reveal internal mechanism between CXCL13 benign prostatic hyperplasia (BPH).Human serum, prostate tissues human cell lines (BPH-1, WPMY-1) were utilized. effect recombinant (rHuCXCL13) protein influences knockdown/overexpression on two studied. Rescue experiments by...
Benign prostatic hyperplasia (BPH) is a common disease in elderly men with uncertain molecular mechanism, and oxidative stress (OS) has also been found associated BPH development. Recently, we that prostate-associated gene 4 (PAGE4) was one of the most significantly changed differentially expressed genes (DEGs) BPH, which can protect cells against stimulation. However, exact role PAGE4 remains unclear. This study aimed at exploring effect under OS. Human prostate tissues cultured WPMY-1 PrPF...
Bladder cancer (BLCA) is an extremely common carcinoma of the urinary system that has a high incidence relapse. Although intensive studies have investigated its pathology in past decades, there are significant knowledge gaps regarding characterization molecular processes underlying progression disease and consequently prognosis. The purpose current research was to identify genes could serve as prognostic biomarkers.Gene expression profiles were downloaded from Cancer Genome Atlas (TCGA) Gene...
To diagnose and explore the genetic etiology of a neonate with Hereditary epidermolysis bullosa.
Abstract Background: Bladder cancer (BLCA) is the most popular malignant carcinomas in genitourinary system which has a high incidence and prone to relapse. However, molecular mechanism of BLCA remains be unclear. Moreover, there still shortage effective biomarkers that can predict progression prognosis BLCA. The objective current study screen significant genes as forecast patients. Methods: Gene expression profile downloaded from TCGA database GEO was used. Differential gene analysis WGCNA...