A5103246810- Urinary Bladder and Prostate Research
- Ferroptosis and cancer prognosis
- Sexual function and dysfunction studies
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Heat shock proteins research
- Natural product bioactivities and synthesis
- Global Public Health Policies and Epidemiology
- Cancer Mechanisms and Therapy
- Cholesterol and Lipid Metabolism
- Adrenal and Paraganglionic Tumors
- Renal and related cancers
- Tissue Engineering and Regenerative Medicine
- Neuroendocrine regulation and behavior
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Occupational and environmental lung diseases
- Erythropoietin and Anemia Treatment
- Phytochemistry and Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- COVID-19 epidemiological studies
Wuhan University
2016-2025
Zhongnan Hospital of Wuhan University
2016-2025
Shanghai University of Traditional Chinese Medicine
2020-2024
Taihe Hospital
2020
Stony Brook University
2017-2019
Tianjin Medical University
2019
Hunan University of Traditional Chinese Medicine
2015-2018
Central South University
2010-2018
Guangzhou Institute of Dermatology
2018
Key Laboratory of Guangdong Province
2018
The convergence of non-communicable disease (NCD) and infectious (ID) in low- middle-income countries (LMICs) presents new challenges opportunities to enact responsive changes policy research. Most LMICs have significant dual burdens NCDs such as cardiovascular disease, diabetes cancer, IDs including tuberculosis, HIV/AIDS parasitic diseases. A combined strategy is needed surveillance control; yet, experts, institutions policies that support prevention control these two overarching...
Benign prostatic hyperplasia (BPH) is a prevalent disorder in aging males. It investigated whether heat shock protein family A member 1A (HSPA1A), cytoprotective chaperone induced under stress, has been implicated the development of BPH. RNA-sequencing and single-cell sequencing analyses revealed significant upregulation HSPA1A BPH compared to controls. In vitro experiments elucidated that was localized epithelium stroma, with upregulated expression tissues. Moreover, silencing augmented...
Human clear cell renal carcinoma (ccRCC) is the most common solid lesion within kidney, and its prognostic influenced by progression covering a complex network of gene interactions.In our study, we screened differential expressed genes, constructed protein-protein interaction (PPI) weighted co-expression to identify key genes pathways associated with ccRCC (n = 56).Functional pathway enrichment analysis demonstrated that upregulated differentially (DEGs) were significantly enriched in...
Vitex negundo L (Verbenaceae) is an aromatic shrub that abundant in Asian countries. A series of compounds from have been used traditional Chinese medicine for the treatment various diseases. Cutaneous melanoma one most aggressive malignancies. significant feature its resistance to chemotherapy and radiotherapy; therefore, there urgent need develop novel treatments melanoma.We first examined effects VB1 (vitexin compound 1) on cell viability by CCK-8 (cell counting kit) Colony Formation...
BackgroundDiabetic foot ulcers (DFUs) are a severe complication of diabetes. Persistent inflammation and impaired vascularization present considerable challenges in tissue wound healing. The aim this study was to identify the crucial regulators DFU healing investigate their specific mechanisms DFU.MethodsDFU RNA sequencing data were obtained feature genes. expression levels genes corresponding microRNAs (miRNAs) verified clinical samples. Subsequently, CD68 determined non-diabetic skin RAW...
On 12 May 2012, over 200 college students with acute diarrhoea were reported to the Guizhou Center for Disease Control and Prevention. We conducted an investigation identify agent mode of transmission recommend control measures.A suspected case was a person at onset ≥ two following symptoms: (more than three loose stools in 24 hours), abdominal pain, vomiting or fever (> 37.5C) between 6 15 2012. A confirmed also had positive Aeromonas hydrophila culture from stool sample....
Abstract Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like like 2 (NELL2) plays multifunctional roles in neural cell strongly linked to the urinary tract disease. Current study aims determine expression, functional activities underlying of NELL2 BPH. Human prostate lines tissues from normal human BPH patients were utilized. Immunohistochemical staining, immunofluorescent RT-polymerase chain reaction...
This research is aimed at establishing a green, rapid method based on HS-GC-IMS to identify three species of Lilii Bulbus.
The aim of the present study was to determine a more specific, efficient and simple method for induction collagen-induced arthritis (CIA) in rats. Different strains rats were injected at base tail with bovine type II collagen (CII) emulsified incomplete Freund's adjuvant (IFA). onset severity evaluated by clinical assessment. established CIA model analyzed using comprehensive examination clinical, hematological, histological radiological parameters. results demonstrated that Wistar most...
MicroRNAs (miRNAs) are small non-coding RNAs, which important in the development of multidrug resistance cancer by regulating gene expression at post‑transcriptional level. The present study investigated functional effects miR‑522 chemoresistant colon cells. results demonstrated that was significantly downregulated doxorubicin (DOX) resistant cell line, HT29/DOX, compared with parental HT29 line. Overexpression HT29/DOX cells partially restored DOX sensitivity. miRNA target prediction...
Adrenocortical carcinoma (ACC) is a limited endocrine fatality with minor diagnosis and rare remedial options. The progressive predictive meaning of message RNA (mRNA) expression oddity in ACC has been studied extensively recent years. However, differences measurement platforms lab protocols as well small sample sizes can render gene levels incomparable.An extensive study GEO datasets was conducted to define potential mRNA biomarkers for ACC. compared the profiles tissues neighboring...
Abstract Background Benign prostatic hyperplasia (BPH) is one of the most common illnesses in aging men. Recent studies found that bone morphogenetic protein 5 (BMP5) upregulated BPH tissues, however, role BMP5 development has not been examined. The current study aims to elucidate potential roles and related signaling pathways BPH. Methods Human prostate cell lines (BPH‐1, WPMY‐1) human/rat hyperplastic tissues were utilized. Western blot, quantitative real‐time polymerase chain reaction,...
Excessive migration and proliferation of vascular smooth muscle cells (VSMCs) are critical cellular events that lead to intimal hyperplasia in atherosclerosis restenosis. In this study, we investigated the protective effects ursodeoxycholic acid (UDCA) on VSMC migration, underlying mechanisms by which these occur. A rat unilateral carotid artery was ligated induce injury microRNA (miRNA) expression profiles were determined using miRNA microarray analysis. We observed UDCA significantly...
Abstract Background Benign prostatic hyperplasia (BPH) is a common disease in elderly men and often accompanied by chronic inflammation. Macrophages (several subtypes) are the main inflammatory cells that infiltrate hyperplastic prostate found to secrete cytokines growth factors. The current study aims explore effect of M2a macrophages on development BPH via insulin‐like factor 1 (IGF‐1). Methods Human tissues, prostate, monocyte cell lines (WPMY‐1, BPH‐1, THP‐1) were used. THP‐1 was...
Abstract Benign prostatic hyperplasia (BPH) is a common disease in aging males. It has been proven that the Hedgehog (HH) implied as an effective and fundamental regulatory growth factor signal for organogenesis, homeostasis, regeneration. Smoothened (SMO), major control point of HH signals, activates aberrantly most human solid tumors. However, specific function SMO its downstream glioma-associated oncogene (GLI) family BPH not well understood. Here, we first revealed cascade was...
Chaihu-Shugan-San (CHSGS) is a herbal preparation that has been shown to effectively relieve neurologic impairment and reduce depression. However, the efficacy of CHSGS in treatment patients with epilepsy depression unknown. Therefore, present study, adult rats were exposed chronic mild stress following establishment pilocarpine-induced epilepsy. Subsequently, sucrose consumption test open-field (OFT) performed assess depression-like behavior. Rats randomly divided into four groups: Control,...
Clear cell renal carcinoma (ccRCC) is the most common type of kidney tumor worldwide. Analysis The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases showed that immune-related gene (IRG) hematopoietic signal transducer (HCST) could provide guidance for diagnosis, prognosis, treatment ccRCC. RNA-seq data ccRCC tissues were extracted from two databases: TCGA ( https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga ) GEO...
To find out the reason why some people get infected directly with multidrug-resistant tuberculosis (MDR-TB), whereas drug-susceptible (DS-TB), a 1:1:1 matched-pairs case-control study was conducted to identify predictors associated primary MDR-TB and DS-TB against control in Jiangsu Province, China. All three groups were geographically matched (by neighborhood) on sex age (±5 years). In total, 110 participants enrolled each of groups. Conditional logistic regression analysis showed that...
Purpose. To investigate the association of biomarkers correlated with clinical stages and survival clear cell renal carcinoma (ccRCC). Methods. The GSE36895 dataset was downloaded differentially expressed or methylated genes were analyzed. Hub identified weighted gene co-expression network analysis (WGCNA) protein-protein interaction (PPI), validated TCGA database our own tissues. biological processes hub further explored by functional enrichment analysis. Survival analyses also performed....
A growing body of data indicates that the kynurenine pathway may play a role in pathogenesis postpartum depressive symptoms (PDS). Kynurenic aminotransferase (KAT) is an important enzyme, catalyzing (KYN) into kynurenic acid (KYNA). This study investigated as to whether genetic variations KAT are associated with PDS. cohort 360 Chinese women scheduled undergo cesarean delivery was enrolled this study. PDS determined by Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13. total eight...